UniProtKB/Swiss-Prot P04637: Variant p.Cys135Thr

Cellular tumor antigen p53
Gene: TP53
Chromosomal location: 17p13.1
Variant information

Variant position:  135
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Unclassified
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants have been found in patients and disease-association is reported in literature. However, this classification is not a definitive assessment of variant pathogenicity.
  • Polymorphism: No disease-association has been reported.
  • Unclassified: Variants have been found in patients but disease-association remains unclear.

Residue change:  From Cysteine (C) to Threonine (T) at position 135 (C135T, p.Cys135Thr).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are medium size and polar.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.
Any additional useful information about the variant.



Sequence information

Variant position:  135
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  393
The length of the canonical sequence.

Location on the sequence:   HSGTAKSVTCTYSPALNKMF  C QLAKTCPVQLWVDSTPPPGT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         HSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGT

Rhesus macaque                HSGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPPGS

Mouse                         QSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGS

Rat                           QSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPPGT

Pig                           HSGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVSSPPPPGT

Bovine                        QSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGT

Rabbit                        HSGTAKSVTCTYSPCLNKLFCQLAKTCPVQLWVDSTPPPGT

Sheep                         HSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGT

Cat                           QSGTAKSVTCTYSPPLNKLFCQLAKTCPVQLWVRSPPPPGT

Dog                           HSGTAKSVTWTYSPLLNKLFCQLAKTCPVQLWVSSPPPPNT

Chicken                       EAGTAKSVTCTYSPVLNKVYCRLAKPCPVQVRVGVAPPPGS

Xenopus laevis                QNGTAKSVTCTYSPELNKLFCQLAKTCPLLVRVESPPPRGS

Zebrafish                     QSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQGS

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Site 120 – 120 Interaction with DNA
Modified residue 120 – 120 N6-acetyllysine; by KAT6A
Beta strand 132 – 135


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.