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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q15633: Variant p.Ser251Phe

RISC-loading complex subunit TARBP2
Gene: TARBP2
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Variant information Variant position: help 251 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Phenylalanine (F) at position 251 (S251F, p.Ser251Phe). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to large size and aromatic (F) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 251 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 366 The length of the canonical sequence.
Location on the sequence: help DARDGNEVEPDDDHFSIGVG S RLDGLRNRGPGCTWDSLRNS The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         DARDGNEVEPDDDHFSIGVGSRLDGLRNRGPGCTWDSLRNS

Mouse                         DARDGNEAEPDDDHFSIGVSSRLDGLRNRGPGCTWDSLRNS

Rat                           DARDGNEAEPDDDHFSIGVSSRLDGLRNRGPGCTWDSLRNS

Bovine                        DARDGNEAEPEDDHFSIGVGSRLDGLRNRGPGCTWDSLRNS

Xenopus laevis                EHRESGETEPEEDQFSVG---KLDGSRSRGTACTWDSLRNS

Xenopus tropicalis            EHRESGETEPEEDQFSMG---KLDGSRGRGTACTWDSLRNS

Zebrafish                     DMRSSHEAEAEDDTFNMQIGGRLEGGKSKGLGCTWDSLRNS

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 366 RISC-loading complex subunit TARBP2
Region 228 – 366 Sufficient for interaction with DICER1



Literature citations
Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR.
Gatignol A.; Buckler-White A.J.; Berkhout B.; Jeang K.T.;
Science 251:1597-1600(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); FUNCTION (MICROBIAL INFECTION); VARIANT PHE-251; Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1).
Kozak C.A.; Gatignol A.; Graham K.; Jeang K.T.; McBride O.W.;
Genomics 25:66-72(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT PHE-251;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.