UniProtKB/Swiss-Prot P10082: Variant p.Arg37Gly

• Variant information
• Sequence information
• Literature citations
• All

Variant information

Variant position: 37 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: LB/B The variants are classified into three categories: LP/P, LB/B and US.

• LP/P: likely pathogenic or pathogenic.
• LB/B: likely benign or benign.
• US: uncertain significance

Residue change: From Arginine (R) to Glycine (G) at position 37 (R37G, p.Arg37Gly). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: Change from large size and basic (R) to glycine (G) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

• Lowest score: -4 (low probability of substitution).
• Highest score: 11 (high probability of substitution).

More information can be found on the following page
Other resources: Links to websites of interest for the variant.

• Variant rs229969 [ dbSNP | Ensembl ]

Sequence information

Variant position: 37 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 97 The length of the canonical sequence.
Location on the sequence: ALLVCLGALVDAYPIKPEAP R EDASPEELNRYYASLRHYLN The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

• Type: the type of sequence feature.
• Positions: endpoints of the sequence feature.
• Description: contains additional information about the feature.

Type	Positions	Description
Peptide	29 – 64	Peptide YY
Peptide	31 – 64	Peptide YY(3-36)
Modified residue	41 – 41	Phosphoserine

Literature citations

Cloning and structural determination of human peptide YY cDNA and gene.
Kohri K.; Nata K.; Yonekura H.; Nagai A.; Konno K.; Okamoto H.;
Biochim. Biophys. Acta 1173:345-349(1993)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2); VARIANTS GLY-37 AND ARG-72; Genomic organisation and localisation of the gene for the human peptide YY.
Herzog H.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT GLY-37; Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).
Halleck A.; Ebert L.; Mkoundinya M.; Schick M.; Eisenstein S.; Neubert P.; Kstrang K.; Schatten R.; Shen B.; Henze S.; Mar W.; Korn B.; Zuo D.; Hu Y.; LaBaer J.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2); VARIANTS GLY-37 AND ARG-72; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS GLY-37 AND ARG-72; Isolation and primary structure of human peptide YY.
Tatemoto K.; Nakano I.; Makk G.; Angwin P.; Mann M.; Schilling J.; Go V.L.W.;
Biochem. Biophys. Res. Commun. 157:713-717(1988)
Cited for: PROTEIN SEQUENCE OF 29-64; AMIDATION AT TYR-64; SYNTHESIS OF 29-64; VARIANT GLY-37; A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36).
Eberlein G.A.; Eysselein V.E.; Schaeffer M.; Layer P.; Grandt D.; Goebell H.; Niebel W.; Davis M.; Lee T.D.; Shively J.E.; Reeve J.R. Jr.;
Peptides 10:797-803(1989)
Cited for: PROTEIN SEQUENCE OF 29-64; AMIDATION AT TYR-64; VARIANT GLY-37;