Variant position: 65 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 280 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YRWDPDKAGDKPHMQTYEVD LNKCGPMVLDALIKIKNEVDS
Mouse YRWDPDKTGDKPRMQTYEVD LNKCGPMVLDALIKIKNEVDS
Rat YRWDPDKAGDKPRMQTYKVD LNKCGPMVLDALIKIKNEIDS
Pig YRWDPDKTGDKPHMQTYEID LNNCGPMVLDALIKIKNEIDS
Bovine YRWDPDKTGDKPHMQTYEID LNNCGPMVLDALIKIKNEIDS
Chicken YRWDPDKPGDKPRMQTYEVD LNKCGPMVLDALIKIKNELDS
Xenopus laevis YRWDPDKPGDKPRMQTYEVD LNTCGPMVLDALIKIKNEVDP
Xenopus tropicalis YRWDPDKPGDKPRMQTYEVD LNECGSMVLDALIKIKNEMDP
Zebrafish YRWDPDTVGDKPRMQTYEID LNTCGPMVLDALIKIKNEMDS
Caenorhabditis elegans YRFNPEAPGAKPTVQKFDVD LDQCGTMILDALIKIKNEVDP
Drosophila YRWNPDNAGEKPYMQTYEVD LRECGPMVLDALIKIKNEMDP
Slime mold YRYN-EETTAKPYIQTYNIN LKDCGPMVLDALLLIKNNIDP
Baker's yeast YRWNPDEPSAKPHLQSYQVD LNDCGPMVLDALLKIKDEQDS
Fission yeast YRWNPEKPEVKPKLQKYTVD LTKCGPMVLDALIKIKNEQDP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
29 – 280 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
40 – 133 2Fe-2S ferredoxin-type
51 – 51 N6-acetyllysine
55 – 55 N6-acetyllysine
Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas.
Benn D.E.; Croxson M.S.; Tucker K.; Bambach C.P.; Richardson A.L.; Delbridge L.; Pullan P.T.; Hammond J.; Marsh D.J.; Robinson B.G.;
Cited for: VARIANTS PHEOCHROMOCYTOMA GLN-46 AND HIS-65;
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