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Variant position: 438The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 671The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation:The multiple alignment of the region surrounding the variant against various orthologous sequences.
Sequence annotation in neighborhood:The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
- Type: the type of sequence feature.
- Positions: endpoints of the sequence feature.
- Description: contains additional information about the feature.
||1 – 671
||Receptor-interacting serine/threonine-protein kinase 1
||290 – 582
||Interaction with SQSTM1
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.
Hsu H.; Huang J.; Shu H.-B.; Baichwal V.R.; Goeddel D.V.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); AUTOPHOSPHORYLATION; MUTAGENESIS OF LYS-45; INTERACTION WITH TRADD; TRAF1; TRAF2 AND TRAF3; VARIANT VAL-438;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT VAL-438;
RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.
Stanger B.Z.; Leder P.; Lee T.-H.; Kim E.; Seed B.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-671; VARIANT VAL-438;
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