Variant position: 81 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 446 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FFVISLAVSDLLVAVLVMPW KAVAEIAGFWPFGSFCNIWVA
Rhesus macaque FFVISLAVSDLLVAVLVMPW KAVAEIAGFWPFGSFCNIWVA
Mouse FFVISLAVSDLLVAVLVMPW KAVAEIAGFWPFGSFCNIWVA
Rat FFVISLAVSDLLVAVLVMPW KAVAEIAGFWPLGPFCNIWVA
Pig FFVISLAVSDLLVAVLVMPW KAVAEIAGFWPFGSFCNIWVA
Bovine FFVISLAVSDLLVAVLVMPW KAVAEIAGFWPFGSFCNIWVA
Xenopus laevis FFVISLAVSDLLVAVLVMPW KAVAEIAGFWPFGTFCNIWVA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 446 D(1A) dopamine receptor
61 – 87 Helical; Name=2;
A population-specific HTR2B stop codon predisposes to severe impulsivity.
Bevilacqua L.; Doly S.; Kaprio J.; Yuan Q.; Tikkanen R.; Paunio T.; Zhou Z.; Wedenoja J.; Maroteaux L.; Diaz S.; Belmer A.; Hodgkinson C.A.; Dell'osso L.; Suvisaari J.; Coccaro E.; Rose R.J.; Peltonen L.; Virkkunen M.; Goldman D.;
Cited for: VARIANTS ARG-81 AND TYR-259;
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