UniProtKB/Swiss-Prot Q15831: Variant p.Asp208Asn

Serine/threonine-protein kinase STK11
Gene: STK11
Chromosomal location: 19p13.3
Variant information

Variant position:  208
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Unclassified
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants have been found in patients and disease-association is reported in literature. However, this classification is not a definitive assessment of variant pathogenicity.
  • Polymorphism: No disease-association has been reported.
  • Unclassified: Variants have been found in patients but disease-association remains unclear.

Residue change:  From Aspartate (D) to Asparagine (N) at position 208 (D208N, p.Asp208Asn).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and acidic (D) to medium size and polar (N)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In colorectal cancer; somatic mutation; no effect heterotrimeric complex assembly with STRADA and CAB39.
Any additional useful information about the variant.



Sequence information

Variant position:  208
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  433
The length of the canonical sequence.

Location on the sequence:   GTLKISDLGVAEALHPFAAD  D TCRTSQGSPAFQPPEIANGL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         GTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGL

Mouse                         GTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGL

Rat                           GTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGL

Chicken                       GTLKISDLGVAEALHPFAEDDTCRTSQGSPAFQPPEIANGL

Xenopus laevis                GTLKISDLGVAEALHPFAEGDTCRTSQGSPAFQPPEIANGL

Slime mold                    NVLKLSDFGVAEDSSQLEDFECLSRSYGSPAFQPPELTQFQ

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 430 Serine/threonine-protein kinase STK11
Domain 49 – 309 Protein kinase
Modified residue 189 – 189 Phosphothreonine; by autocatalysis
Mutagenesis 189 – 189 T -> A. Reduced phosphorylation.
Mutagenesis 194 – 194 D -> A. Loss of kinase activity.
Mutagenesis 204 – 204 F -> A. No effect. Impaired formation of a heterotrimeric complex with STRADA and CAB39; when associated with A-74.


Literature citations

Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
Dong S.M.; Kim K.M.; Kim S.Y.; Shin M.S.; Na E.Y.; Lee S.H.; Park W.S.; Yoo N.J.; Jang J.J.; Yoon C.Y.; Kim J.W.; Kim S.Y.; Yang Y.M.; Kim S.H.; Kim C.S.; Lee J.Y.;
Cancer Res. 58:3787-3790(1998)
Cited for: VARIANTS COLORECTAL CANCER SER-171; LYS-199; ASN-208; ASP-215; LEU-354 AND MET-367;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.