Variant position: 255 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 643 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DYGRVNTAAVNLVPGDPRWI GAWWLGLLISSALLVLTSFPF
Mouse DYGRVDTATVNLSPGDPRWI GAWWLGLLISSGFLIVTSLPF
Rat DYGRVDTATVNLSPGDPRWI GAWWLGLLISSGFLIVTSLPF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 643 Solute carrier organic anion transporter family member 2A1
255 – 279 Helical; Name=6
Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy.
Zhang Z.; Xia W.; He J.; Zhang Z.; Ke Y.; Yue H.; Wang C.; Zhang H.; Gu J.; Hu W.; Fu W.; Hu Y.; Li M.; Liu Y.;
Am. J. Hum. Genet. 90:125-132(2012)
Cited for: VARIANTS PHOAR2 ARG-222 AND GLU-255;
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