Variant position: 157 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 175 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LSSDGVLTVNGPRKQVSGPE RTIPITREEKPAVTAAPKK
Mouse LSSDGVLTVNGPRKQVSGPE RTIPITREEKPAVAAAPKK
Rat LSSDGVLTVNGPRKQASGPE RTIPITREEKPAVTAAPKK
Pig LSSDGVLTVNGPRRQASGPE RTIPITREEKPAVTAAPKK
Bovine LSSDGVLTVNGPRKQASGPE RTIPITREEKPAVTAAPKK
Rabbit LSSDGVLTVNGPRKQAPGPE RTIPITREEKPAVTAAPKK
Sheep LSSDGVLTMNGPRKQASGPE RTIPITREEKPAVTAAPKK
Chicken LSLDGVLTVSAPRKQSDVPE RSIPITREEKPAIAGSQRK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 175 Alpha-crystallin B chain
166 – 166 N6-acetyllysine
170 – 170 O-linked (GlcNAc)
157 – 159
Alpha B-crystallin mutation in dilated cardiomyopathy.
Inagaki N.; Hayashi T.; Arimura T.; Koga Y.; Takahashi M.; Shibata H.; Teraoka K.; Chikamori T.; Yamashina A.; Kimura A.;
Biochem. Biophys. Res. Commun. 342:379-386(2006)
Cited for: VARIANT CMD1II HIS-157;
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