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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O43933: Variant p.Arg581Pro

Peroxisomal ATPase PEX1
Gene: PEX1
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Variant information Variant position: help 581 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Arginine (R) to Proline (P) at position 581 (R581P, p.Arg581Pro). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (R) to medium size and hydrophobic (P) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In HMLR1; results in mild functional decrease in peroxisome biogenesis. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 581 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 1283 The length of the canonical sequence.
Location on the sequence: help SLGVSSLEHITHSLLGRPLS R QLMSLVAGLRNGALLLTGGK The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         SLGVSSLEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGGK

Mouse                         ALGASAMEHITHSLLGRPLSRQLMALVAGLRNGALLITGGK

Slime mold                    KQIKQAKEFLSLYMY-KDLSVIREQLNTPGVNG-MIIAGSH

Baker's yeast                 RTSKDEDDFITVNSIKKEMVNYLTSPI--IATPAIILDGKQ

Fission yeast                 -----NAVFLHQNIY---------------------INGPK
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 1283 Peroxisomal ATPase PEX1



Literature citations
Heimler syndrome is caused by hypomorphic mutations in the peroxisome-biogenesis genes PEX1 and PEX6.
Ratbi I.; Falkenberg K.D.; Sommen M.; Al-Sheqaih N.; Guaoua S.; Vandeweyer G.; Urquhart J.E.; Chandler K.E.; Williams S.G.; Roberts N.A.; El Alloussi M.; Black G.C.; Ferdinandusse S.; Ramdi H.; Heimler A.; Fryer A.; Lynch S.A.; Cooper N.; Ong K.R.; Smith C.E.; Inglehearn C.F.; Mighell A.J.; Elcock C.; Poulter J.A.; Tischkowitz M.; Davies S.J.; Sefiani A.; Mironov A.A.; Newman W.G.; Waterham H.R.; Van Camp G.;
Am. J. Hum. Genet. 97:535-545(2015)
Cited for: INVOLVEMENT IN HMLR1; VARIANTS HMLR1 PRO-581 AND TRP-705; CHARACTERIZATION OF VARIANTS HMLR1 PRO-581 AND TRP-705;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.