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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P01112: Variant p.Ser89Cys

GTPase HRas
Gene: HRAS
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Variant information Variant position: help 89 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help US The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Cysteine (C) at position 89 (S89C, p.Ser89Cys). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to medium size and polar (C) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help Found in a patient with severe fetal hydrops and pleural effusion; uncertain significance; decreased activation of Ras protein signal transduction. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 89 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 189 The length of the canonical sequence.
Location on the sequence: help DQYMRTGEGFLCVFAINNTK S FEDIHQYREQIKRVKDSDDV The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         DQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDV

Mouse                         DQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDV

Rat                           DQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDV

Chicken                       DQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDV

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 186 GTPase HRas
Chain 2 – 186 GTPase HRas, N-terminally processed
Mutagenesis 83 – 83 A -> T. GTP-binding activity reduced by factor of 30.
Helix 87 – 104



Literature citations
A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development.
Gripp K.W.; Bifeld E.; Stabley D.L.; Hopkins E.; Meien S.; Vinette K.; Sol-Church K.; Rosenberger G.;
Am. J. Med. Genet. A 158A:2106-2118(2012)
Cited for: FUNCTION; VARIANT CYS-89; CHARACTERIZATION OF VARIANT CYS-89;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.