Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P67870: Variant p.Arg111Pro

Casein kinase II subunit beta
Gene: CSNK2B
Feedback?
Variant information Variant position: help 111 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Arginine (R) to Proline (P) at position 111 (R111P, p.Arg111Pro). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (R) to medium size and hydrophobic (P) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In POBINDS. Any additional useful information about the variant.


Sequence information Variant position: help 111 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 215 The length of the canonical sequence.
Location on the sequence: help NRGIAQMLEKYQQGDFGYCP R VYCENQPMLPIGLSDIPGEA The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         NRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEA

Mouse                         NRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEA

Rat                           NRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEA

Pig                           NRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEA

Bovine                        NRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEA

Rabbit                        NRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEA

Chicken                       NRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEA

Xenopus laevis                NRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEA

Zebrafish                     NRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEA

Caenorhabditis elegans        NRGISQMVEKWRDHDFGVCPRVYCENQPMLPIGLSDVPGEA

Drosophila                    NRGIAQMIEKYQTGDFGHCPRVYCESQPMLPLGLSDIPGEA

Baker's yeast                 KPGLQAMAEKFDHKEFGTCPRYYCNGMQLLPCGLSDTVGKH

Fission yeast                 AQGLYKMLEKYKKCDFGHCPRVLCNGQPMLPVGLSDIAHTK

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 215 Casein kinase II subunit beta
Binding site 109 – 109
Binding site 114 – 114



Literature citations
Germline de novo variants in CSNK2B in Chinese patients with epilepsy.
Li J.; Gao K.; Cai S.; Liu Y.; Wang Y.; Huang S.; Zha J.; Hu W.; Yu S.; Yang Z.; Xie H.; Yan H.; Wang J.; Wu Y.; Jiang Y.;
Sci. Rep. 9:17909-17909(2019)
Cited for: INVOLVEMENT IN POBINDS; VARIANTS POBINDS 5-GLU--ARG-215 DEL; CYS-86; PRO-111; GLY-137; PHE-137 AND ARG-187;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.