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This service will be shut down by the end of February 2022.
You can find most of the protein databases available here at the UniProt BLAST service. For nucleotide databases we recommend to use the EBI BLAST service or the NCBI BLAST service.
SIB BLAST+ Network Service Form

You can also use this tool programmatically...
Enter a sequence

Examples
e.g. P00750, P05067-5, A4_HUMAN or acccgtggtcgctgctg... help
Enter a query protein or nucleotide sequence into the text area. Accepted input:
  • UniProtKB accession or identifier
  • bare sequence
  • sequence in FASTA format
BLAST programs available on ExPASy: help

  • blastp compares a protein query sequence against a protein sequence database.
  • blastn compares a nucleotide query sequence against a nucleotide sequence database.
  • tblastn compares a protein query sequence against a nucleotide sequence database dynamically translated in all reading frames.
  • blastx compares a nucleotide query sequence translated in all reading frames against a protein sequence database.
blastp:protein query->protein sequence database
blastn:nucleotide query->nucleotide sequence database
tblastn:protein query->nucleotide sequence database
blastx:nucleotide query->protein sequence database


Choose a database
Protein databases:
   UniProtKB/Swiss-Prot only. help UniProtKB/Swiss-Prot is the manually annotated and reviewed part of UniProtKB.
If you choose to perform a BLAST against UniProtKB 'Complete database', 'Proteomes', 'Reference proteomes' or a taxonomic subset of UniProtKB, you may restrict the search to UniProtKB/Swiss-Prot.
help
WARNING: This is post-processing of the results: the BLAST is performed on 'Complete database', and only results fulfilling the taxonomic criteria you have entered are shown. This will decrease your hits and statistically bias your results.

ADVICE: If the taxon you're interested in is in the 'UniProtKB taxonomic subsets' select menu (below), we strongly suggest you use that list instead.

Optional field, only applied if the target database is 'Complete database' and the output format is 'html'.
Enter a species name, a TaxID or the latin name of a taxonomic group (elements of the UniProtKB OC, OS and OX lines) to view only the results belonging to that taxonomic group.
You may enter a list separated by exclamation mark ("!")
Examples:
  • Fungi! Homo sapiens
  • 4751! 9606
   UniProtKB/Swiss-Prot only. help UniProtKB/Swiss-Prot is the manually annotated and reviewed part of UniProtKB.
If you choose to perform a BLAST against UniProtKB 'Complete database', 'Proteomes', 'Reference proteomes' or a taxonomic subset of UniProtKB, you may restrict the search to UniProtKB/Swiss-Prot.