Cellosaurus HEL (CVCL_0001)

Cell line name HEL
Synonyms Hel; GM06141; Human ErythroLeukemia
Accession CVCL_0001
Resource Identification Initiative To cite this cell line use: HEL (RRID:CVCL_0001)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~24 hours (PubMed=6177045); ~36 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Homozygous for JAK2 p.Val617Phe (PubMed=16408098).
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Erythroleukemia (NCIt: C7152)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_KS72 (CellSensor irf1-bla HEL); CVCL_4360 (Dami); CVCL_2481 (HEL 92.1.7)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; COG; DSMZ; JCRB PubMed=25877200

Markers:
AmelogeninX,Y (COG; PubMed=25877200)
X (Cosmic-CLP; DSMZ; JCRB)
CSF1PO10
D13S3179,11
D16S53911
D18S5116 (COG)
12,16 (PubMed=25877200)
D19S43311,13
D21S1129,30.2,31.2 (COG)
29,30.2 (PubMed=25877200)
D2S133818,19
D3S135815
D5S81811
D7S8207
D8S117913,15
FGA22,23
Penta D11,13
Penta E13,18
TH017
TPOX11
vWA14,17
Web pages http://www.proteinatlas.org/learn/cellines
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-346.html
Publications

PubMed=6177045; DOI=10.1126/science.6177045
Martin P., Papayannopoulou T.
HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression.
Science 216:1233-1235(1982)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections Coriell; GM06141
DSMZ; ACC-11
JCRB; JCRB0062
KCB; KCB 200808YJ
Cell line databases/resources CLDB; cl0
CLDB; cl1585
CCLE; HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CCRID; 3131C0001000700071
CCRID; 3142C0001000000070
Cosmic-CLP; 907053
GDSC; 907053
LINCS_LDP; LCL-1053
Ontologies BTO; BTO:0000565
CLO; CLO_0003679
CLO; CLO_0023565
EFO; EFO_0006579
MCCL; MCC:0000187
Biological sample resources BioSample; SAMN03471056
BioSample; SAMN03472269
Chemistry resources ChEMBL-Cells; CHEMBL3308090
ChEMBL-Targets; CHEMBL613888
Gene expression databases GEO; GSM482506
GEO; GSM887077
GEO; GSM888147
GEO; GSM1028243
GEO; GSM1446763
GEO; GSM1669874
Polymorphism and mutation databases Cosmic; 787432
Cosmic; 798663
Cosmic; 907053
Cosmic; 919128
Cosmic; 924040
Cosmic; 975251
Cosmic; 976722
Cosmic; 994176
Cosmic; 996314
Cosmic; 1012051
Cosmic; 1013868
Cosmic; 1037665
Cosmic; 1070698
Cosmic; 1078733
Cosmic; 1122162
Cosmic; 1127268
Cosmic; 1139508
Cosmic; 1139638
Cosmic; 1140092
Cosmic; 1151879
Cosmic; 1168467
Cosmic; 1170892
Cosmic; 1171333
Cosmic; 1176583
Cosmic; 1191710
Cosmic; 1192825
Cosmic; 1601067
Cosmic; 1633512
Cosmic; 1943609
Cosmic; 2089667
Cosmic; 2131538
Cosmic; 2306207