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Cellosaurus HMC-1 (CVCL_0003)

[Text version]

Cell line name HMC-1
Synonyms HMC1
Accession CVCL_0003
Resource Identification Initiative To cite this cell line use: HMC-1 (RRID:CVCL_0003)
Comments Doubling time: 3-4 days (PubMed=3131594).
Omics: Deep antibody staining analysis.
Omics: Deep RNAseq analysis.
Derived from sampling site: Peripheral blood; mast cell.
Sequence variations Mutation; HGNC; 6342; KIT; Simple; p.Val560Gly (c.1679T>G); ClinVar=VCV000375916; Zygosity=Heterozygous (PubMed=7691885).
Mutation; HGNC; 6342; KIT; Simple; p.Asp816Val (c.2447A>T); ClinVar=VCV000013852; Zygosity=Heterozygous (PubMed=7691885).
Disease Mast cell leukemia (NCIt: C3169)
Mast cell leukemia (ORDO: Orphanet_98851)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4T80 (HMC-1 5C6)CVCL_H206 (HMC-1.1)CVCL_H205 (HMC-1.2)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): DSMZ


Run an STR similarity search on this cell line
Web pages https://www.proteinatlas.org/learn/cellines

PubMed=3131594; DOI=10.1016/0145-2126(88)90050-1
Butterfield J.H., Weiler D., Dewald G., Gleich G.J.
Establishment of an immature mast cell line from a patient with mast cell leukemia.
Leuk. Res. 12:345-355(1988)

PubMed=7691885; DOI=10.1172/JCI116761
Furitsu T., Tsujimura T., Tono T., Ikeda H., Kitayama H., Koshimizu U., Sugahara H., Butterfield J.H., Ashman L.K., Kanayama Y., Matsuzawa Y., Kitamura Y., Kanakura Y.
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
J. Clin. Invest. 92:1736-1744(1993)

PubMed=8191224; DOI=10.1111/j.1365-3083.1994.tb03404.x
Nilsson G., Blom T., Kusche-Gullberg M., Kjellen L., Butterfield J.H., Sundstrom C., Nilsson K., Hellman L.
Phenotypic characterization of the human mast-cell line HMC-1.
Scand. J. Immunol. 39:489-498(1994)

PubMed=8950460; DOI=10.1007/BF02505297
Weber S., Babina M., Kruger-Krasagakes S., Grutzkau A., Henz B.M.
A subclone (5C6) of the human mast cell line HMC-1 represents a more differentiated phenotype than the original cell line.
Arch. Dermatol. Res. 288:778-782(1996)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Cell line collections DSMZ; ACC-283 - Discontinued
Cell line databases/resources Lonza; 502
TOKU-E; 3534
Ontologies BTO; BTO:0001669
MCCL; MCC:0000199
Biological sample resources BioSample; SAMN03473342
Other Wikidata; Q54889906
Polymorphism and mutation databases Cosmic; 821806
Cosmic; 821913
Cosmic; 822147
Cosmic; 1122161
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number19