Cell line name | NB4 | ||||||||||||||||||||||||||||||||
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Synonyms | NB-4; NB.4 | ||||||||||||||||||||||||||||||||
Accession | CVCL_0005 | ||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: NB4 (RRID:CVCL_0005) | ||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: ENCODE project common cell types; tier 3. Part of: LL-100 blood cancer cell line panel. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2030. Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-1045. Doubling time: 36-40 hours (PubMed=1995093); 30 hours (PubMed=25984343); ~35-45 hours (DSMZ). Microsatellite instability: Stable (MSS) (Sanger). Omics: Cell surface proteome. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: shRNA library screening. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Bone marrow. | ||||||||||||||||||||||||||||||||
Sequence variations | Gene fusion; PML-RARA (PubMed=12353268; PubMed=15843827).Heterozygous for KRAS p.Ala18Asp (c.53C>A) (CCLE; Cosmic-CLP).Homozygous for TP53 p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (Cosmic-CLP). | ||||||||||||||||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Acute promyelocytic leukemia with PML-RARA (NCIt: C3182) Acute promyelocytic leukemia (ORDO: Orphanet_520) | ||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Sex of cell | Female | ||||||||||||||||||||||||||||||||
Age at sampling | 23Y | ||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||
STR profile | Source(s): CLS; Cosmic-CLP; DSMZ; PubMed=25877200 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
Web pages | http://www.proteinatlas.org/learn/cellines http://genome.ucsc.edu/ENCODE/protocols/cell/human/NB4_protocol.pdf | ||||||||||||||||||||||||||||||||
Publications | PubMed=1995093; DOI=10.1182/blood.V77.5.1080.1080 PubMed=1453773 PubMed=7630193 Patent=US5589345 PubMed=9737686; DOI=10.1038/sj.leu.2401112 DOI=10.1016/B978-0-12-221970-2.50457-5 PubMed=11704857; DOI=10.1038/sj.onc.1204863 PubMed=12353268; DOI=10.1002/gcc.10117 PubMed=14504097; DOI=10.1182/blood-2003-02-0418 PubMed=15843827; DOI=10.1038/sj.leu.2403749 PubMed=16408098; DOI=10.1038/sj.leu.2404081 PubMed=22460905; DOI=10.1038/nature11003 PubMed=23325432; DOI=10.1101/gr.147942.112 PubMed=23955599; DOI=10.1038/ng.2731 PubMed=25984343; DOI=10.1038/sdata.2014.35 PubMed=25894527; DOI=10.1371/journal.pone.0121314 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=30285677; DOI=10.1186/s12885-018-4840-5 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 PubMed=31160637; DOI=10.1038/s41598-019-44491-x | ||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||
Cell line collections | CLS; 300299/p11500_NB-4
CLS; 300299-SF/p11500_NB-4 DSMZ; ACC-207 NCBI_Iran; C515 | ||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl3643
CCLE; NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE Cell_Model_Passport; SIDM00428 Cosmic-CLP; 1323913 DepMap; ACH-000294 LINCS_LDP; LCL-1084 Lonza; 749 | ||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0002136
CLO; CLO_0007947 EFO; EFO_0002798 MCCL; MCC:0000350 | ||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03470835
BioSample; SAMN10988571 ENCODE; ENCBS032SIL ENCODE; ENCBS259AAA ENCODE; ENCBS390ENC | ||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308423
ChEMBL-Targets; CHEMBL614188 GDSC; 1323913 PharmacoDB; NB4_990_2019 | ||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 ArrayExpress; E-MTAB-7721 ArrayExpress; E-MTAB-7722 GEO; GSM236798 GEO; GSM236834 GEO; GSM472929 GEO; GSM510512 GEO; GSM510513 GEO; GSM887349 GEO; GSM888426 GEO; GSM945252 GEO; GSM945275 GEO; GSM1374696 GEO; GSM1374697 GEO; GSM1446740 GEO; GSM1670151 | ||||||||||||||||||||||||||||||||
Other | Wikidata; Q54907527 | ||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 787463
Cosmic; 850391 Cosmic; 922661 Cosmic; 924050 Cosmic; 975285 Cosmic; 981582 Cosmic; 996313 Cosmic; 1012107 Cosmic; 1037664 Cosmic; 1070692 Cosmic; 1078721 Cosmic; 1089522 Cosmic; 1127257 Cosmic; 1181601 Cosmic; 1523826 Cosmic; 1524838 Cosmic; 1601063 Cosmic; 1604862 Cosmic; 1779130 Cosmic; 2036677 Cosmic; 2089653 Cosmic; 2131548 Cosmic; 2306227 Cosmic; 2579202 IARC_TP53; 21530 IARC_TP53; 21705 LiGeA; CCLE_910 Progenetix; CVCL_0005 | ||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD000589
PRIDE; PXD001610 | ||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||||||
Version number | 33 |