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Cellosaurus THP-1 (CVCL_0006)

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Cell line name THP-1
Synonyms THP1; THP 1; THPI; THP-1(ATCC); Tohoku Hospital Pediatrics-1
Accession CVCL_0006
Resource Identification Initiative To cite this cell line use: THP-1 (RRID:CVCL_0006)
Comments Group: Space-flown cell line (cellonaut).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: RAS genetic alteration cell panel (ATCC TCP-1031).
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Characteristics: Can differentiate from monocytes into macrophage-like cells upon stimulation with PMA.
Doubling time: 60-70 hours (PubMed=6970727); 26 hours (PubMed=25984343); ~35-50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep promoter analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Glycoproteome analysis by proteomics.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Anecdotal: Have been flown in space on Cosmos-2044 to study the inhibition of phorbol ester-induced cell activation in microgravity (PubMed=352912).
Caution: NRAS mutation indicated incorrectly as being p.Gly12Ser in PubMed=9379676.
Derived from sampling site: Peripheral blood.
Sequence variations CSNK2A1-DDX39B gene fusion (PubMed=31160637).
KMT2A-MLLT3 (MLL-MLLT3; MLL-AF9) gene fusion (PubMed=11066077; PubMed=15843827).
Heterozygous for NRAS p.Gly12Asp (c.35G>A) (PubMed=12068308; ATCC; CCLE; Cosmic-CLP).
Heterozygous for TP53 p.Arg174fs*3 (c.520_545del26) (PubMed=1571549; CCLE).
HLA typing Source: PubMed=22674354
Class I
HLA-AA*02
HLA-BB*15:11
HLA-CC*03
Class II
HLA-DQDQB1*05,06
HLA-DRDRB1*01,15
DRB5*01/02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.3
East Asian, North77.63
East Asian, South20.4
South Asian1.67
European, North0
European, South0
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5115 (A-THP-1)CVCL_X687 (BF24)CVCL_KB46 (CellSensor NFkB-bla THP-1)
CVCL_KS29 (CellSensor SIE-bla THP-1)CVCL_KS30 (CellSensor TNFalpha-bla THP-1)CVCL_KZ70 (PathHunter THP-1 IkappaB Degradation)
CVCL_IR08 (PSC-THP1)CVCL_DF52 (THP-1 NucLight Red)CVCL_WI26 (THP-1/AR)
CVCL_4V22 (THP-1/ara-C)CVCL_0R21 (THP-1/DC-SIGN)CVCL_XD94 (THP-1/IL15)
CVCL_XD95 (THP-1/IL21)CVCL_0R25 (THP-1(NCI))CVCL_3426 (THP-1h)
CVCL_3427 (THP-1l)CVCL_X588 (THP1-Blue ISG)CVCL_X589 (THP1-Blue ISG-KD-STING)
CVCL_X585 (THP1-Blue NF-kappaB)CVCL_X598 (THP1-defASC)CVCL_5I76 (THP1-defCASP1)
CVCL_X600 (THP1-defNLRP3)CVCL_X599 (THP1-Dual)CVCL_X587 (THP1-Lucia ISG)
CVCL_X590 (THP1-Lucia NF-kappaB)CVCL_5I77 (THP1-NLRC4)CVCL_X601 (THP1-Null)
CVCL_X582 (THP1-Xblue)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; DSMZ; ECACC; ICLC; JCRB; KCLB; PubMed=11416159; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO11,13
D2S133817,18
D3S135815,17
D5S81811,12
D7S82010
D8S117910,14
D13S31713 (AddexBio; ATCC; CLS; Cosmic-CLP; ECACC; JCRB; KCLB; PubMed=25877200)
8,13 (CCRID; DSMZ; RCB; TKG)
D16S53911,12
D18S5113,14
D19S43312.2,13,14
D21S1130,31.2
FGA24,25
Penta D10,12
Penta E11,15
TH018,9.3 (AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; DSMZ; ECACC; ICLC; KCLB; PubMed=11416159; PubMed=25877200; RCB; TKG)
8,10 (JCRB)
TPOX8,11
vWA16 (AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; ECACC; ICLC; JCRB; KCLB; PubMed=11416159; PubMed=25877200)
16,17 (DSMZ; RCB; TKG)

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/THP-1_cell_line
http://www.proteinatlas.org/learn/cellines
https://strap.nci.nih.gov/celline_detail.php?sample_id=78
http://www.bowdish.ca/lab/wp-content/uploads/2011/07/THP-1-propagation-culture.pdf
http://www.infarktforschung.de/macrophages_cell_lines.html
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/t/cell-lines-detail-444.html
http://tcpaportal.org/mclp/
http://www.cellresource.cn/fdetail.aspx?id=57
http://www.cellresource.cn/fdetail.aspx?id=430
http://www.cellresource.cn/fdetail.aspx?id=625
http://www.cellresource.cn/fdetail.aspx?id=882
Publications

PubMed=6970727; DOI=10.1002/ijc.2910260208
Tsuchiya S., Yamabe M., Yamaguchi Y., Kobayashi Y., Konno T., Tada K.
Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).
Int. J. Cancer 26:171-176(1980)

PubMed=6091813
Palumbo A., Minowada J., Erikson J., Croce C.M., Rovera G.
Lineage infidelity of a human myelogenous leukemia cell line.
Blood 64:1059-1063(1984)

PubMed=1915666; DOI=10.1016/0014-4827(91)90482-A
Limouse M., Manie S., Konstantinova I., Ferrua B., Schaffar L.
Inhibition of phorbol ester-induced cell activation in microgravity.
Exp. Cell Res. 197:82-86(1991)

PubMed=1571549
Sugimoto K., Toyoshima H., Sakai R., Miyagawa K., Hagiwara K., Ishikawa F., Takaku F., Yazaki Y., Hirai H.
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9379676; DOI=10.1016/S0145-2126(97)00036-2
Sheng X.-M., Kawamura M., Ohnishi H., Ida K., Hanada R., Kojima S., Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.
Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.
Leuk. Res. 21:697-701(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=11066077; DOI=10.1002/1098-2264(2000)9999:9999<::AID-GCC1040>3.0.CO;2-Z
Odero M.D., Zeleznik-Le N.J., Chinwalla V., Rowley J.D.
Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation.
Genes Chromosomes Cancer 29:333-338(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R., Tsuchida M., Sugita K., Ida K., Hayashi Y.
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Drexler H.G., Quentmeier H., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=19377474; DOI=10.1038/ng.375
Suzuki H., Forrest A.R.R., van Nimwegen E., Daub C.O., Balwierz P.J., Irvine K.M., Lassmann T., Ravasi T., Hasegawa Y., de Hoon M.J.L., Katayama S., Schroder K., Carninci P., Tomaru Y., Kanamori-Katayama M., Kubosaki A., Akalin A., Ando Y., Arner E., Asada M., Asahara H., Bailey T., Bajic V.B., Bauer D., Beckhouse A.G., Bertin N., Bjorkegren J., Brombacher F., Bulger E., Chalk A.M., Chiba J., Cloonan N., Dawe A., Dostie J., Engstrom P.G., Essack M., Faulkner G.J., Fink J.L., Fredman D., Fujimori K., Furuno M., Gojobori T., Gough J., Grimmond S.M., Gustafsson M., Hashimoto M., Hashimoto T., Hatakeyama M., Heinzel S., Hide W., Hofmann O., Hornquist M., Huminiecki L., Ikeo K., Imamoto N., Inoue S., Inoue Y., Ishihara R., Iwayanagi T., Jacobsen A., Kaur M., Kawaji H., Kerr M.C., Kimura R., Kimura S., Kimura Y., Kitano H., Koga H., Kojima T., Kondo S., Konno T., Krogh A., Kruger A., Kumar A., Lenhard B., Lennartsson A., Lindow M., Lizio M., MacPherson C., Maeda N., Maher C.A., Maqungo M., Mar J., Matigian N.A., Matsuda H., Mattick J.S., Meier S., Miyamoto S., Miyamoto-Sato E., Nakabayashi K., Nakachi Y., Nakano M., Nygaard S., Okayama T., Okazaki Y., Okuda-Yabukami H., Orlando V., Otomo J., Pachkov M., Petrovsky N., Plessy C., Quackenbush J., Radovanovic A., Rehli M., Saito R., Sandelin A., Schmeier S., Schonbach C., Schwartz A.S., Semple C.A., Sera M., Severin J., Shirahige K., Simons C., St Laurent G., Suzuki M., Suzuki T., Sweet M.J., Taft R.J., Takeda S., Takenaka Y., Tan K., Taylor M.S., Teasdale R.D., Tegner J., Teichmann S.A., Valen E., Wahlestedt C., Waki K., Waterhouse A., Wells C.A., Winther O., Wu L., Yamaguchi K., Yanagawa H., Yasuda J., Zavolan M., Hume D.A., Arakawa T., Fukuda S., Imamura K., Kai C., Kaiho A., Kawashima T., Kawazu C., Kitazume Y., Kojima M., Miura H., Murakami K., Murata M., Ninomiya N., Nishiyori H., Noma S., Ogawa C., Sano T., Simon C., Tagami M., Takahashi Y., Kawai J., Hayashizaki Y.
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.
Nat. Genet. 41:553-562(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22645513; DOI=10.3389/fendo.2011.00089
Keuper M., Dzyakanchuk A., Amrein K.E., Wabitsch M., Fischer-Posovszky P.
THP-1 macrophages and SGBS adipocytes - a new human in vitro model system of inflamed adipose tissue.
Front. Endocrinol. 2:89-89(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22481983; DOI=10.2174/1874091X01206010016
Chauhan V., Howland M., Wilkins R.
Effects of alpha-particle radiation on microRNA responses in human cell-lines.
Open Biochem. J. 6:16-22(2012)

PubMed=23097634; DOI=10.1100/2012/205038
Chauhan V., Howland M.
Genomic profiling of a human leukemic monocytic cell-line (THP-1) exposed to alpha particle radiation.
ScientificWorldJournal 2012:205038-205038(2012)

PubMed=22674354; DOI=10.1002/ijc.27661
Battle R., Poole K., Haywood-Small S., Clark B., Woodroofe M.N.
Molecular characterisation of the monocytic cell line THP-1 demonstrates a discrepancy with the documented HLA type.
Int. J. Cancer 132:246-247(2013)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=24368162; DOI=10.1016/j.exphem.2013.12.004
Sripayap P., Nagai T., Uesawa M., Kobayashi H., Tsukahara T., Ohmine K., Muroi K., Ozawa K.
Mechanisms of resistance to azacitidine in human leukemia cell lines.
Exp. Hematol. 42:294-306(2014)

PubMed=25130606; DOI=10.1016/j.intimp.2014.08.002
Chanput W., Mes J.J., Wichers H.J.
THP-1 cell line: an in vitro cell model for immune modulation approach.
Int. Immunopharmacol. 23:37-45(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26421875; DOI=10.1089/ten.TEC.2015.0188
Yamazoe H., Hagihara Y., Kobayashi H.
Multicomponent coculture system of cancer cells and two types of stromal cells for in vitro evaluation of anticancer drugs.
Tissue Eng. Part C Methods 22:20-29(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28404994; DOI=10.1038/s41598-017-00828-y
Muller M.M., Lehmann R., Klassert T.E., Reifenstein S., Conrad T., Moore C., Kuhn A., Behnert A., Guthke R., Driesch D., Slevogt H.
Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFalpha expression.
Sci. Rep. 7:838-838(2017)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections AddexBio; C0003024/4956
ATCC; TIB-202
BCRC; 60430
BCRJ; 0234
CCTCC; GDC0100
CLS; 300356/p804_THP-1
DSMZ; ACC-16
ECACC; 88081201
ICLC; HTL97014
IZSLER; BS TCL 138
JCRB; JCRB0112
JCRB; JCRB0112.1
KCB; KCB 200549YJ
KCLB; 40202
NCBI_Iran; C563
NIH-ARP; 9942-142
RCB; RCB1189
RCB; RCB3686
TKG; TKG 0267
Cell line databases/resources CLDB; cl4513
CLDB; cl4514
CLDB; cl4515
CLDB; cl4517
CCLE; THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CCRID; 3111C0001CCC000057
CCRID; 3111C0002000000058
CCRID; 3131C0001000700057
CCRID; 3142C0001000000114
Cell_Model_Passport; SIDM01172
Cosmic-CLP; 909771
DepMap; ACH-000146
GDSC; 909771
IGRhCellID; THP1
LINCS_HMS; 50861
LINCS_LDP; LCL-1072
Lonza; 134
Ontologies BTO; BTO:0001370
CLO; CLO_0009348
CLO; CLO_0050999
EFO; EFO_0001253
MCCL; MCC:0000461
Biological sample resources BioSample; SAMN03470795
BioSample; SAMN03473256
BioSample; SAMN03473419
BioSample; SAMN10987847
eagle-i; hawaii.eagle-i.net/i/0000012b-5668-8366-2f73-b43980000000
Chemistry resources ChEMBL-Cells; CHEMBL3307574
ChEMBL-Targets; CHEMBL614245
PharmacoDB; THP1_1593_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM236807
GEO; GSM236843
GEO; GSM482495
GEO; GSM887706
GEO; GSM888799
GEO; GSM1374962
GEO; GSM1446742
GEO; GSM1670543
GEO; GSM2141952
GEO; GSM2141956
GEO; GSM2141958
GEO; GSM2141959
GEO; GSM2141962
GEO; GSM2141968
GEO; GSM2141972
GEO; GSM2141974
GEO; GSM2141979
GEO; GSM2141986
GEO; GSM2141987
GEO; GSM2141993
GEO; GSM2141995
GEO; GSM2141998
GEO; GSM2141999
GEO; GSM2142000
GEO; GSM2142004
GEO; GSM2142005
GEO; GSM2142009
GEO; GSM2142011
GEO; GSM2142015
GEO; GSM2142016
GEO; GSM2142019
GEO; GSM2142021
GEO; GSM2142023
GEO; GSM2142024
GEO; GSM2142028
GEO; GSM2142029
GEO; GSM2142030
GEO; GSM2142031
GEO; GSM2142036
GEO; GSM2142037
GEO; GSM2142039
GEO; GSM2142048
GEO; GSM2142049
GEO; GSM2142052
GEO; GSM2142053
GEO; GSM2142055
GEO; GSM2142059
GEO; GSM2142060
Other Wikidata; Q7670282
Polymorphism and mutation databases Cosmic; 717684
Cosmic; 724818
Cosmic; 787480
Cosmic; 909771
Cosmic; 919122
Cosmic; 924051
Cosmic; 947361
Cosmic; 975303
Cosmic; 991556
Cosmic; 996316
Cosmic; 998748
Cosmic; 1012124
Cosmic; 1037666
Cosmic; 1070694
Cosmic; 1078722
Cosmic; 1089517
Cosmic; 1150901
Cosmic; 1176587
Cosmic; 1181604
Cosmic; 1187864
Cosmic; 1197931
Cosmic; 1278779
Cosmic; 1281356
Cosmic; 1319551
Cosmic; 1476425
Cosmic; 1519163
Cosmic; 1524842
Cosmic; 1601064
Cosmic; 1604863
Cosmic; 2089655
Cosmic; 2131559
Cosmic; 2306241
Cosmic; 2392976
IARC_TP53; 2198
LiGeA; CCLE_181
Proteomic databases PRIDE; PRD000345
PRIDE; PXD000328
PRIDE; PXD000953
PRIDE; PXD004034
PRIDE; PXD008516
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number32