Cell line name | U-937 | ||||||||||||||||||||||||||||||||||||
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Synonyms | U937; U 937 | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_0007 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: U-937 (RRID:CVCL_0007) | ||||||||||||||||||||||||||||||||||||
Comments | Group: Space-flown cell line (cellonaut). Problematic cell line: Partially contaminated. Some ATCC stocks were cross-contaminated by K-562 initially (PubMed=7759961). The problem was corrected and subsequent stocks have been confirmed to carry only U-937. Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: LL-100 blood cancer cell line panel. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00168. Characteristics: Can be induced to differentiate into macrophages by several factors such as phorbol ester (PMA) and 12-O-tetradecanoyl-13-phorbol acetate (TPA). Doubling time: 95-100 hours (PubMed=178611); ~30-40 hours (DSMZ). Karyotypic information: Has lost chromosome Y. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep proteome analysis. Omics: Deep quantitative proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: Proteome analysis by 2D-DE/MS. Omics: SNP array analysis. Omics: Transcriptome analysis. Anecdotal: Have been flown in space on shuttle flight STS-76 and on Shenzhou-8 to study growth and cytoskeletal changes in microgravity (PubMed=10352142; DOI=10.1016/j.actaastro.2013.06.007). Discontinued: TKG; TKG 0279; probable. Derived from sampling site: Pleural effusion. | ||||||||||||||||||||||||||||||||||||
Sequence variations | Gene fusion; PICALM-MLLT10 (CALM-AF10) (PubMed=8643484; PubMed=25485619).Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (PubMed=10966170; CCLE).Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59) (ClinVar=VCV000428908); Note=Splice donor mutation (PubMed=1571549; CCLE). | ||||||||||||||||||||||||||||||||||||
HLA typing | Source: IPD-IMGT/HLA; 11507
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Genome ancestry | Source: PubMed=30894373
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Disease | Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Sex of cell | Male | ||||||||||||||||||||||||||||||||||||
Age at sampling | 37Y | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio; ATCC; CCRID; CLS; COG; DSMZ; ECACC; JCRB; KCLB; PubMed=11416159; PubMed=15637111; PubMed=25877200; RCB Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/U937_cells http://www.cells-talk.com/index.php/page/copelibrary?key=U937 http://www.proteinatlas.org/learn/cellines http://www.infarktforschung.de/macrophages_cell_lines.html http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/u/cell-lines-detail-315.html http://www.nibsc.org/Default.aspx?pageid=597&id=0012&theme=default http://www.cellresource.cn/fdetail.aspx?id=59 http://www.cellresource.cn/fdetail.aspx?id=627 http://www.cellresource.cn/fdetail.aspx?id=725 http://www.cellresource.cn/fdetail.aspx?id=846 | ||||||||||||||||||||||||||||||||||||
Publications | DOI=10.1007/978-1-4757-1647-4_13 PubMed=178611; DOI=10.1002/ijc.2910170504 PubMed=1083890; DOI=10.1084/jem.143.6.1528 PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059 PubMed=6582512; DOI=10.1073/pnas.81.2.568 DOI=10.1159/000415060 PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x DOI=10.1007/978-94-011-3550-4_20 PubMed=1913629; DOI=10.1016/0304-3835(91)90051-I PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378 PubMed=8300570 PubMed=7759961; DOI=10.1002/jlb.57.5.804 PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x PubMed=8558913 PubMed=8558920 PubMed=8643484; DOI=10.1073/pnas.93.10.4804 PubMed=9371509 PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x PubMed=9685479; DOI=10.1093/nar/26.16.3651 PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x PubMed=10352142; DOI=10.1096/fasebj.13.9001.s23 PubMed=10676951; DOI=10.1038/35000501 PubMed=10966170; DOI=10.1034/j.1600-0609.2000.90181.x PubMed=11701946; DOI=10.1159/000048774 PubMed=12393283; DOI=10.1016/S0165-4608(02)00565-4 PubMed=15637111; DOI=10.1096/fj.04-3062fje PubMed=15843827; DOI=10.1038/sj.leu.2403749 PubMed=16408098; DOI=10.1038/sj.leu.2404081 PubMed=20801507; DOI=10.1016/j.leukres.2010.07.040 PubMed=21269460; DOI=10.1186/1752-0509-5-17 PubMed=22460905; DOI=10.1038/nature11003 DOI=10.1016/j.actaastro.2013.06.007 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=30285677; DOI=10.1186/s12885-018-4840-5 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 PubMed=31160637; DOI=10.1038/s41598-019-44491-x DOI=10.21203/rs.3.rs-94743/v1 PubMed=31978347; DOI=10.1016/j.cell.2019.12.023 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections | AddexBio; C0003005/72
ATCC; CRL-1593 - Discontinued ATCC; CRL-1593.2 BCRC; 60435 BCRJ; 0242 CCTCC; GDC0080 CLS; 300368/p474_U-937 DSMZ; ACC-5 ECACC; 85011440 ICLC; HTL94002 IZSLER; BS TCL 73 JCRB; IFO50038 JCRB; JCRB9021 KCB; KCB 200676YJ KCLB; 21593.1 NCBI_Iran; C130 RCB; RCB1978 - Discontinued TKG; TKG 0279 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl4597
CLDB; cl4599 CLDB; cl4600 CLDB; cl4601 CLDB; cl4602 CLDB; cl4603 CLDB; cl4604 CLDB; cl4605 CLDB; cl4606 CLDB; cl4608 CCLE; U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCRID; 3111C0001CCC000059 CCRID; 3131C0001000700059 CCRID; 3131C0001000700159 CCRID; 3142C0001000000078 Cell_Model_Passport; SIDM01195 DepMap; ACH-000406 IPD-IMGT/HLA; 11507 LINCS_HMS; 50869 LINCS_LDP; LCL-1125 Lonza; 135 TOKU-E; 3382 | ||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0001412
CLO; CLO_0009450 CLO; CLO_0009465 EFO; EFO_0001257 MCCL; MCC:0000470 MeSH; D020298 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03472409
BioSample; SAMN03473173 BioSample; SAMN03473567 BioSample; SAMN10988180 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308006
ChEMBL-Targets; CHEMBL612794 PharmacoDB; U937_1624_2019 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-7721 ArrayExpress; E-MTAB-7722 GEO; GSE66854 GEO; GSM2020 GEO; GSM236809 GEO; GSM236845 GEO; GSM482491 GEO; GSM743413 GEO; GSM887724 GEO; GSM888818 GEO; GSM1028244 GEO; GSM1028245 GEO; GSM1374975 GEO; GSM1670560 | ||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q7863610 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 787483
Cosmic; 798666 Cosmic; 821044 Cosmic; 850382 Cosmic; 852000 Cosmic; 919123 Cosmic; 922162 Cosmic; 932770 Cosmic; 947364 Cosmic; 975307 Cosmic; 991558 Cosmic; 994178 Cosmic; 999781 Cosmic; 1012127 Cosmic; 1019837 Cosmic; 1067446 Cosmic; 1070690 Cosmic; 1078726 Cosmic; 1082516 Cosmic; 1086353 Cosmic; 1089523 Cosmic; 1107178 Cosmic; 1127260 Cosmic; 1150904 Cosmic; 1176581 Cosmic; 1181605 Cosmic; 1191692 Cosmic; 1465967 Cosmic; 1523828 Cosmic; 1524826 Cosmic; 1582388 Cosmic; 1601066 Cosmic; 1604865 Cosmic; 1995661 Cosmic; 2301570 Cosmic; 2361376 Cosmic; 2750876 IARC_TP53; 2199 LiGeA; CCLE_826 Progenetix; CVCL_0007 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD001521
PRIDE; PXD001522 PRIDE; PXD001523 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||||||||||
Version number | 35 |