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Cellosaurus HDLM-2 (CVCL_0009)

[Text version]

Cell line name HDLM-2
Synonyms HD-LM-2; HDLM2
Accession CVCL_0009
Resource Identification Initiative To cite this cell line use: HDLM-2 (RRID:CVCL_0009)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Doubling time: ~70-75 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Cell surface proteome.
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Pleural effusion.
Sequence variations TP53 p.Ser261fs c.?(782delins) (PubMed=17065008).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.09
Native American0
East Asian, North1.64
East Asian, South0
South Asian0.05
European, North62.14
European, South35.08
Disease Hodgkin lymphoma (NCIt: C9357)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_M696 (HDLM-2d)
Originate from same individual CVCL_M693 ! HDLM-1
CVCL_M697 ! HDLM-3
Sex of cell Male
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811
D7S8208,10
D13S31711,12
D16S53912
TH016,7
TPOX8
vWA19

Run an STR similarity search on this cell line
Web pages http://www.proteinatlas.org/learn/cellines
Publications

PubMed=3713248; DOI=10.1016/0145-2126(86)90084-6
Drexler H.G., Gaedicke G., Lok M.-S., Diehl V., Minowada J.
Hodgkin's disease derived cell lines HDLM-2 and L-428: comparison of morphology, immunological and isoenzyme profiles.
Leuk. Res. 10:487-500(1986)

PubMed=2602652; DOI=10.1007/978-3-642-83781-4_8
Drexler H.G., Gignac S.M., Hoffbrand A.V., Leber B.F., Norton J., Lok M.-S., Minowada J.
Characterization of Hodgkin's disease derived cell line HDLM-2.
Recent Results Cancer Res. 117:75-82(1989)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E., Tesch H., Fonatsch C., Stein H., Diehl V.
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=8558920
Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=9685479; DOI=10.1093/nar/26.16.3651
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12581897; DOI=10.1016/S0165-4608(02)00656-8
Berglund M., Flordal E., Gullander J., Lui W.-O., Larsson C., Lagercrantz S., Enblad G.
Molecular cytogenetic characterization of four commonly used cell lines derived from Hodgkin lymphoma.
Cancer Genet. Cytogenet. 141:43-48(2003)

PubMed=17065008; DOI=10.1080/10428190600667721
Feuerborn A., Moritz C., Von Bonin F., Dobbelstein M., Trumper L., Sturzenhofecker B., Kube D.
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.
Leuk. Lymphoma 47:1932-1940(2006)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections DSMZ; ACC-17
Cell line databases/resources CLDB; cl1580
CCLE; HDLM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01064
Cosmic-CLP; 924110
DepMap; ACH-000267
GDSC; 924110
IGRhCellID; HDLM2
LINCS_LDP; LCL-2007
Ontologies CLO; CLO_0003671
Biological sample resources BioSample; SAMN03473364
BioSample; SAMN10988513
Chemistry resources ChEMBL-Cells; CHEMBL3308234
ChEMBL-Targets; CHEMBL2366231
PharmacoDB; HDLM2_521_2019
Gene expression databases ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM335390
GEO; GSM381298
GEO; GSM499724
GEO; GSM499732
GEO; GSM552430
GEO; GSM646534
GEO; GSM887064
GEO; GSM888134
GEO; GSM1669870
Other Wikidata; Q54882175
Polymorphism and mutation databases Cosmic; 924110
Cosmic; 988701
Cosmic; 1013909
Cosmic; 1086355
Cosmic; 1278832
Cosmic; 1289699
Cosmic; 1290220
Cosmic; 1432040
Cosmic; 2276322
Cosmic; 2464309
IARC_TP53; 23613
Proteomic databases PRIDE; PXD000589
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number28