Cellosaurus HDLM-2 (CVCL_0009)

Cell line name HDLM-2
Synonyms HD-LM-2; HDLM2
Accession CVCL_0009
Resource Identification Initiative To cite this cell line use: HDLM-2 (RRID:CVCL_0009)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~70-75 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Cell surface proteome.
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Pleural effusion.
Disease Hodgkin lymphoma (NCIt: C9357)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_M696 (HDLM-2d)
Originate from same individual CVCL_M693 ! HDLM-1
CVCL_M697 ! HDLM-3
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S31711,12
D16S53912
D5S81811
D7S8208,10
TH016,7
TPOX8
vWA19
Web pages http://www.proteinatlas.org/learn/cellines
Publications

PubMed=3713248; DOI=10.1016/0145-2126(86)90084-6
Drexler H.G., Gaedicke G., Lok M.-S., Diehl V., Minowada J.
Hodgkin's disease derived cell lines HDLM-2 and L-428: comparison of morphology, immunological and isoenzyme profiles.
Leuk. Res. 10:487-500(1986)

PubMed=2602652; DOI=10.1007/978-3-642-83781-4_8
Drexler H.G., Gignac S.M., Hoffbrand A.V., Leber B.F., Norton J., Lok M.S., Minowada J.
Characterization of Hodgkin's disease derived cell line HDLM-2.
Recent Results Cancer Res. 117:75-82(1989)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E., Tesch H., Fonatsch C., Stein H., Diehl V.
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=9685479; DOI=10.1093/nar/26.16.3651
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=12581897; DOI=10.1016/S0165-4608(02)00656-8
Berglund M., Flordal E., Gullander J., Lui W.-O., Larsson C., Lagercrantz S., Enblad G.
Molecular cytogenetic characterization of four commonly used cell lines derived from Hodgkin lymphoma.
Cancer Genet. Cytogenet. 141:43-48(2003)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-17
Cell line databases/resources CLDB; cl1580
CCLE; HDLM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 924110
GDSC; 924110
IGRhCellID; HDLM2
LINCS_LDP; LCL-2007
Lonza; 471
Ontologies CLO; CLO_0003671
Biological sample resources BioSample; SAMN03473364
Chemistry resources ChEMBL-Cells; CHEMBL3308234
ChEMBL-Targets; CHEMBL2366231
Gene expression databases GEO; GSM335390
GEO; GSM381298
GEO; GSM499724
GEO; GSM499732
GEO; GSM552430
GEO; GSM646534
GEO; GSM887064
GEO; GSM888134
GEO; GSM1669870
Polymorphism and mutation databases Cosmic; 924110
Cosmic; 988701
Cosmic; 1013909
Cosmic; 1086355
Cosmic; 1278832
Cosmic; 1289699
Cosmic; 1290220
Cosmic; 1432040
Cosmic; 2276322
Cosmic; 2464309
Proteomic databases PRIDE; PXD000589