Home  |  Contact

Cellosaurus D341 Med (CVCL_0018)

[Text version]

Cell line name D341 Med
Synonyms D-341 Med; D-341 MED; D-341Med; D-341MED; D341_Med; D341Med; D341MD; D-341; D341; Med 341; H341
Accession CVCL_0018
Resource Identification Initiative To cite this cell line use: D341 Med (RRID:CVCL_0018)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: ENCODE project common cell types; tier 3.
Doubling time: 37 hours (ATCC).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Miscellaneous: The values for the STR markers F13A01, F13B, FESFPS and LPL used to be shown on the ATCC website but are no longer displayed (see Internet archive link for archival version).
Derived from sampling site: Brain; cerebellum.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North1.21
East Asian, South0
South Asian0.49
European, North68.21
European, South30.09
Disease Medulloblastoma (NCIt: C3222)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3Y5M
Category Cancer cell line
STR profile Source(s): ATCC; CCRID


Run an STR similarity search on this cell line
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/MedulloD341_Crawford_protocol.pdf

Friedman H.S., Burger P.C., Bigner S.H., Trojanowski J.Q., Brodeur G.M., He X.-M., Wikstrand C.J., Kurtzberg J., Berens M.E., Halperin E.C., Bigner D.D.
Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.
Am. J. Pathol. 130:472-484(1988)

Wikstrand C.J., Friedman H.S., Bigner D.D.
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

PubMed=8275086; DOI=10.1038/ng1193-230
Galili N., Davis R.J., Fredericks W.J., Mukhopadhyay S., Rauscher F.J. III, Emanuel B.S., Rovera G., Barr F.G.
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
Nat. Genet. 5:230-235(1993)

Ali-Osman F.
Brain tumors.
(In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York (1999)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20847082; DOI=10.1093/neuonc/noq091
Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y., Marquez V.E., Cho Y.-J., Pomeroy S.L.
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
In vitro models of medulloblastoma: Choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31963405; DOI=10.3390/cancers12010226
Casciati A., Tanori M., Manczak R., Saada S., Tanno B., Giardullo P., Porcu E., Rampazzo E., Persano L., Viola G., Dalmay C., Lalloue F., Pothier A., Merla C., Mancuso M.
Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype.
Cancers (Basel) 12:226.1-226.14(2020)

Cell line collections ATCC; HTB-187
KCB; KCB 2010239YJ
Cell line databases/resources CCLE; D341MED_CENTRAL_NERVOUS_SYSTEM
CCRID; 3111C0001CCC000102
Cell_Model_Passport; SIDM01492
DepMap; ACH-000095
IGRhCellID; D341Med
Ontologies CLO; CLO_0002677
EFO; EFO_0002157
Biological sample resources BioSample; SAMN03472737
BioSample; SAMN10988120
Chemistry resources ChEMBL-Cells; CHEMBL3308450
ChEMBL-Targets; CHEMBL614478
PharmacoDB; D341Med_280_2019
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2770
GEO; GSM482333
GEO; GSM827339
GEO; GSM886970
GEO; GSM888039
GEO; GSM918117
GEO; GSM919358
GEO; GSM1008577
Other Wikidata; Q54817217
Polymorphism and mutation databases Cosmic; 923657
Cosmic; 973263
Cosmic; 974282
Cosmic; 975025
Cosmic; 1097759
Cosmic; 2362652
Cosmic; 2731178
Cosmic; 2772984
LiGeA; CCLE_586
Progenetix; CVCL_0018
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number26