Cell line name | U-87MG ATCC | ||||||||||||||||||||||||||||||||||||
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Synonyms | U-87MG; U-87 MG; U87 MG; U-87-MG; U87-MG; U87MG; U-87; U87; 87 MG; 87MG | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_0022 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: U-87MG ATCC (RRID:CVCL_0022) | ||||||||||||||||||||||||||||||||||||
Comments | Problematic cell line: Misidentified. This cell line is not the original glioblastoma cell line established in 1968 at the University of Uppsala. As described in PubMed=27582061 it is most probably also a glioblastoma cell line but whose origin is unknow. See U-87MG Uppsala (CVCL_GP63) for the original U-87MG cell line. Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: ENCODE project common cell types; tier 3. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00535. Doubling time: 72 hours (PubMed=25984343); ~34 hours (PBCF). Microsatellite instability: Stable (MSS) (Sanger). Omics: Cell surface proteome. Omics: CNV analysis. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep proteome analysis. Omics: Deep quantitative proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: Genome sequenced. Omics: HLA class I peptidome analysis by proteomics. Omics: shRNA library screening. Omics: SNP array analysis. Omics: Transcriptome analysis. | ||||||||||||||||||||||||||||||||||||
Sequence variations | Mutation; IDH1; none detected (PubMed=19435942).Heterozygous for NF1 p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT) (ClinVar=VCV000420078) (CCLE; Cosmic-CLP).Homozygous for PTEN c.209+1G>T (ClinVar=VCV000229705); Note=Splice donor mutation (PubMed=9090379; CCLE; Cosmic-CLP).TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (PubMed=31068700).Mutation; TP53; none detected (CCLE; Cosmic-CLP). | ||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=25960936
Source: PubMed=27412690
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Genome ancestry | Source: PubMed=30894373
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Disease | Glioblastoma (NCIt: C3058) Glioblastoma (ORDO: Orphanet_360) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Sex of cell | Male | ||||||||||||||||||||||||||||||||||||
Age at sampling | Age unspecified | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; ECACC; KCLB; PubMed=11416159; PubMed=22570425; PubMed=25877200; PubMed=27582061 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/U87 https://physics.cancer.gov/docs/bioresource/brain/NCI-PBCF-HTB14_U-87_MG_SOP-508.pdf https://strap.nci.nih.gov/celline_detail.php?sample_id=58 http://www.proteinatlas.org/learn/cellines http://genome.ucsc.edu/ENCODE/protocols/cell/human/U-87_Myers_protocol.pdf http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/u/cell-lines-detail-314.html http://www.cellresource.cn/fdetail.aspx?id=208 http://www.cellresource.cn/fdetail.aspx?id=706 http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=327080; DOI=10.1093/jnci/59.1.221 PubMed=833871; DOI=10.1093/jnci/58.2.209 PubMed=450131; DOI=10.1038/279797a0 PubMed=22282976; DOI=10.1093/carcin/1.1.21 PubMed=7459858 PubMed=3518877; DOI=10.3109/07357908609038260 PubMed=7763724 PubMed=8069455; DOI=10.1007/BF02631450 PubMed=9090379; DOI=10.1038/ng0497-356 PubMed=10074188; DOI=10.1128/JVI.73.4.3338-3350.1999 PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x PubMed=10560660; DOI=10.1097/00005072-199911000-00007 PubMed=11414198; DOI=10.1007/s004320000207 PubMed=11966317; DOI=10.1667/0033-7587(2002)157[0516:LDRHIH]2.0.CO;2 PubMed=14614447; DOI=10.1038/sj.onc.1207198 PubMed=16232199; DOI=10.1111/j.1349-7006.2005.00099.x PubMed=16697959; DOI=10.1016/j.ccr.2006.03.030 PubMed=19365568; DOI=10.1371/journal.pone.0005209 PubMed=19435942; DOI=10.1215/15228517-2009-025 PubMed=20126413; DOI=10.1371/journal.pgen.1000832 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=20587068; DOI=10.1186/1471-2407-10-339 PubMed=20593219; DOI=10.1007/s11060-010-0283-9 PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112 PubMed=22460905; DOI=10.1038/nature11003 PubMed=22570425; DOI=10.1093/neuonc/nos072 PubMed=23325432; DOI=10.1101/gr.147942.112 PubMed=25960936; DOI=10.4161/21624011.2014.954893 PubMed=25984343; DOI=10.1038/sdata.2014.35 PubMed=25894527; DOI=10.1371/journal.pone.0121314 PubMed=26496030; DOI=10.18632/oncotarget.6171 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=27412690; DOI=10.1074/mcp.M116.060350 PubMed=27582061; DOI=10.1126/scitranslmed.aaf6853 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 PubMed=31978347; DOI=10.1016/j.cell.2019.12.023 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections | AddexBio; C0005002/71
ATCC; HTB-14 BCRC; 60360 BCRJ; 0241 CCTCC; GDC0157 CLS; 300367/p658_U-87_MG ECACC; 89081402 IBRC; C10982 ICLC; HTL00013 IZSLER; BS TCL 189 KCB; KCB 2011101YJ KCLB; 30014 NCBI_Iran; C531 NIH-ARP; 2188-324 RCB; RCB0419 - Discontinued | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl4592
CLDB; cl4594 CLDB; cl4595 CLDB; cl7166 CCLE; U87MG_CENTRAL_NERVOUS_SYSTEM CCRID; 3111C0001CCC000208 CCRID; 3131C0001000700138 Cell_Model_Passport; SIDM01189 CGH-DB; 157-1 Cosmic-CLP; 687590 DepMap; ACH-000075 LINCS_HMS; 50868 LINCS_LDP; LCL-1364 Lonza; 37 Lonza; 808 TOKU-E; 3381 | ||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0002036
CLO; CLO_0009463 CLO; CLO_0009464 EFO; EFO_0005237 MCCL; MCC:0000469 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03472715
BioSample; SAMN03473126 BioSample; SAMN05292456 BioSample; SAMN07710026 BioSample; SAMN07710027 BioSample; SAMN07710028 BioSample; SAMN07710029 BioSample; SAMN07710030 BioSample; SAMN07710031 BioSample; SAMN07710032 BioSample; SAMN10988360 ENCODE; ENCBS424ENC | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307575
ChEMBL-Targets; CHEMBL614247 GDSC; 687590 PharmacoDB; U87MG_1623_2019 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 GEO; GSM101687 GEO; GSM101688 GEO; GSM101676 GEO; GSM101686 GEO; GSM326243 GEO; GSM481417 GEO; GSM500897 GEO; GSM887723 GEO; GSM888817 GEO; GSM923437 GEO; GSM1374974 GEO; GSM1670559 GEO; GSM2113436 GEO; GSM2113437 GEO; GSM2113438 GEO; GSM2113439 | ||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q7863603 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 687590
Cosmic; 849853 Cosmic; 850741 Cosmic; 850822 Cosmic; 920816 Cosmic; 1036336 Cosmic; 1064099 Cosmic; 1066234 Cosmic; 1171224 Cosmic; 1175825 Cosmic; 1198263 Cosmic; 1217671 Cosmic; 1219449 Cosmic; 1237542 Cosmic; 1294951 Cosmic; 1610737 Cosmic; 1746951 Cosmic; 1945859 Cosmic; 2302316 Cosmic; 2367555 Cosmic; 2491106 Cosmic; 2516044 Cosmic; 2550364 Cosmic; 2568870 Cosmic; 2580918 Cosmic; 2701083 IARC_TP53; 21096 LiGeA; CCLE_552 Progenetix; CVCL_0022 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD000589
PRIDE; PXD000661 PRIDE; PXD001565 PRIDE; PXD003790 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||||||||||
Version number | 36 |