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Cellosaurus SCLC-21H (CVCL_0024)

[Text version]

Cell line name SCLC-21H
Synonyms SCLC21H
Accession CVCL_0024
Resource Identification Initiative To cite this cell line use: SCLC-21H (RRID:CVCL_0024)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 45-85 hours, depending on growth medium (PubMed=3029138); >45 hours (PubMed=2438285); ~2 days (DSMZ).
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 p.Pro278Arg (c.833C>G) (CCLE).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01,32:01
HLA-BB*07:02,07:02
HLA-CC*02:02,02:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.58
Native American1.19
East Asian, North1.82
East Asian, South0
South Asian0
European, North61.58
European, South34.82
Disease Small cell lung carcinoma (NCIt: C4917)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_X025 (SCLC-16HC)CVCL_8262 (SCLC-24H)
Originate from same individual CVCL_2186 ! SCLC-22H
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): CLS; DSMZ; PubMed=11416159; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10
D3S135815
D5S81811,12
D7S82011
D8S117912,13
D13S31712
D16S53912
D18S5114,15
D21S1129,31.2
FGA22 (CLS)
22,23 (PubMed=11416159; PubMed=25877200)
Penta D9
Penta E12,13
TH019.3
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pages http://www.proteinatlas.org/learn/cellines
Publications

PubMed=2438285; DOI=10.1007/BF00396382
Bepler G., Jaques G., Koehler A., Gropp C., Havemann K.
Markers and characteristics of human SCLC cell lines. Neuroendocrine markers, classical tumor markers, and chromosomal characteristics of permanent human small cell lung cancer cell lines.
J. Cancer Res. Clin. Oncol. 113:253-259(1987)

PubMed=3029138; DOI=10.1007/BF00389964
Bepler G., Jaques G., Neumann K., Aumuller G., Gropp C., Havemann K.
Establishment, growth properties, and morphological characteristics of permanent human small cell lung cancer cell lines.
J. Cancer Res. Clin. Oncol. 113:31-40(1987)

PubMed=2473086
Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., De Leij L., Carney D.N., Vooijs G.P., Ramaekers F.C.S.
Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines.
J. Cell Sci. 91:91-108(1988)

PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y
Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A., Boerman O.C., Ramaekers F.C.S.
Novel antigens characteristic of neuroendocrine malignancies.
Cancer 67:619-633(1991)

PubMed=1320893; DOI=10.1159/000163712
Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M., Carney D.N., Bepler G., Roebroeck A.J.M., van de Ven W.J.M., Burbach J.P.
Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.
Pathobiology 60:136-142(1992)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections CLS; 300225/p722_SCLC-21H
DSMZ; ACC-372
Cell line databases/resources CCLE; SCLC21H_LUNG
Cell_Model_Passport; SIDM00029
DepMap; ACH-000659
GDSC; 753611
LINCS_LDP; LCL-1822
Ontologies CLO; CLO_0008972
EFO; EFO_0006749
Biological sample resources BioSample; SAMN03473050
BioSample; SAMN10988516
Chemistry resources ChEMBL-Cells; CHEMBL3308465
ChEMBL-Targets; CHEMBL1075574
PharmacoDB; SCLC21H_1361_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM784216
GEO; GSM887562
GEO; GSM888645
Other Wikidata; Q54952444
Polymorphism and mutation databases Cosmic; 753611
IARC_TP53; 27236
LiGeA; CCLE_035
Proteomic databases PRIDE; PXD011896
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number28