ID   SCLC-21H
AC   CVCL_0024
SY   SCLC21H
DR   CLO; CLO_0008972
DR   EFO; EFO_0006749
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03473050
DR   BioSample; SAMN10988516
DR   CCLE; SCLC21H_LUNG
DR   Cell_Model_Passport; SIDM00029
DR   ChEMBL-Cells; CHEMBL3308465
DR   ChEMBL-Targets; CHEMBL1075574
DR   CLS; 300225/p722_SCLC-21H
DR   Cosmic; 753611
DR   DepMap; ACH-000659
DR   DSMZ; ACC-372
DR   GDSC; 753611
DR   GEO; GSM784216
DR   GEO; GSM887562
DR   GEO; GSM888645
DR   IARC_TP53; 27236
DR   LiGeA; CCLE_035
DR   LINCS_LDP; LCL-1822
DR   PharmacoDB; SCLC21H_1361_2019
DR   PRIDE; PXD011896
DR   Progenetix; CVCL_0024
DR   Wikidata; Q54952444
RX   PubMed=1320893;
RX   PubMed=1845952;
RX   PubMed=2438285;
RX   PubMed=2473086;
RX   PubMed=3029138;
RX   PubMed=11414198;
RX   PubMed=20164919;
RX   PubMed=22460905;
RX   PubMed=25485619;
RX   PubMed=25960936;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   https://www.proteinatlas.org/learn/cellines
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Characteristics: Infected with a murine leukemia virus-related virus (PubMed=30629668).
CC   Doubling time: 45-85 hours, depending on growth medium (PubMed=3029138); >45 hours (PubMed=2438285); ~2 days (DSMZ).
CC   HLA typing: A*01:01,32:01; B*07:02,07:02; C*02:02,02:02 (PubMed=25960936).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro278Arg (c.833C>G); ClinVar=VCV000376644; Zygosity=Homozygous (CCLE).
CC   Omics: Deep antibody staining analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0.58%; Native American=1.19%; East Asian, North=1.82%; East Asian, South=0%; South Asian=0%; European, North=61.58%; European, South=34.82% (PubMed=30894373).
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): CLS; DSMZ; PubMed=11416159; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 12
ST   D18S51: 14,15
ST   D21S11: 29,31.2
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 12,13
ST   FGA: 22 (CLS)
ST   FGA: 22,23 (PubMed=11416159; PubMed=25877200)
ST   Penta D: 9
ST   Penta E: 12,13
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens
OI   CVCL_2186 ! SCLC-22H
SX   Male
AG   46Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 33
//
RX   PubMed=1320893; DOI=10.1159/000163712;
RA   Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M.,
RA   Carney D.N., Bepler G., Roebroeck A.J.M., van de Ven W.J.M.,
RA   Burbach J.P.;
RT   "Expression of the vasopressin and gastrin-releasing peptide genes in
RT   small cell lung carcinoma cell lines.";
RL   Pathobiology 60:136-142(1992).
//
RX   PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y;
RA   Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A.,
RA   Boerman O.C., Ramaekers F.C.S.;
RT   "Novel antigens characteristic of neuroendocrine malignancies.";
RL   Cancer 67:619-633(1991).
//
RX   PubMed=2438285; DOI=10.1007/BF00396382;
RA   Bepler G., Jaques G., Koehler A., Gropp C., Havemann K.;
RT   "Markers and characteristics of human SCLC cell lines. Neuroendocrine
RT   markers, classical tumor markers, and chromosomal characteristics of
RT   permanent human small cell lung cancer cell lines.";
RL   J. Cancer Res. Clin. Oncol. 113:253-259(1987).
//
RX   PubMed=2473086;
RA   Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., de Leij L.F.M.H.,
RA   Carney D.N., Vooijs G.P., Ramaekers F.C.S.;
RT   "Spontaneous changes in intermediate filament protein expression
RT   patterns in lung cancer cell lines.";
RL   J. Cell Sci. 91:91-108(1988).
//
RX   PubMed=3029138; DOI=10.1007/BF00389964;
RA   Bepler G., Jaques G., Neumann K., Aumuller G., Gropp C., Havemann K.;
RT   "Establishment, growth properties, and morphological characteristics
RT   of permanent human small cell lung cancer cell lines.";
RL   J. Cancer Res. Clin. Oncol. 113:31-40(1987).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H.,
RA   Wolf E., Gabius H.J.;
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893;
RA   Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.;
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404;
RA   Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.;
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:E0210404-E0210404(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//