Cell line name | Caco-2 | ||||||||||||||||||||||||||||||||||||||||||||||
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Synonyms | CaCo-2; CACO-2; Caco 2; CACO 2; CACO2; CaCo2; CaCO2; Caco2; Caco-2/ATCC; Caco-II | ||||||||||||||||||||||||||||||||||||||||||||||
Accession | CVCL_0025 | ||||||||||||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: Caco-2 (RRID:CVCL_0025) | ||||||||||||||||||||||||||||||||||||||||||||||
Comments | Part of: AstraZeneca Colorectal cell line (AZCL) panel. Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: ENCODE project common cell types; tier 3. Part of: MD Anderson Cell Lines Project. Population: Caucasian. Characteristics: Highly permissive to SARS coronavirus (SARS-Cov) infection (PubMed=15316659). Doubling time: ~80 hours (DSMZ); ~32 hours (PBCF); ~60-70 hours (CLS). Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=25926053; PubMed=28683746). Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep phosphoproteome analysis. Omics: Deep proteome analysis. Omics: Deep RNAseq analysis. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: H3K27me3 ChIP-seq epigenome analysis. Omics: H3K36me3 ChIP-seq epigenome analysis. Omics: miRNA expression profiling. Omics: N-glycan profiling. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Colon. | ||||||||||||||||||||||||||||||||||||||||||||||
Sequence variations | Homozygous for APC p.Gln1367Ter (c.4099C>T) (ClinVar=VCV000376060) (PubMed=24755471; CCLE).Heterozygous for CTNNB1 p.Gly245Ala (c.734G>C) (PubMed=9294210).Homozygous for SMAD4 p.Asp351His (c.1051G>C) (ClinVar=VCV000375998) (PubMed=24755471; CCLE).Homozygous for TP53 p.Glu204Ter (c.610G>T) (ClinVar=VCV000977783) (PubMed=16418264; PubMed=24755471; PubMed=28683746; CCLE). | ||||||||||||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=25960936
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Genome ancestry | Source: PubMed=30894373
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Disease | Colon adenocarcinoma (NCIt: C4349) | ||||||||||||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Sex of cell | Male | ||||||||||||||||||||||||||||||||||||||||||||||
Age at sampling | 72Y | ||||||||||||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio; ATCC; CCRID; CLS; DSMZ; ECACC; PubMed=11416159; PubMed=25877200; PubMed=25926053; RCB Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/Caco-2 https://www.phe-culturecollections.org.uk/media/171256/caco-2-cell-line-profile.pdf http://www.proteinatlas.org/learn/cellines http://en.vircell.com/products/caco-2-cell-line/ http://www.sygnis.com/caco-2/ http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-37.html http://www.cyprotex.com/admepk/in-vitro-permeability/caco-2-permeability/ https://physics.cancer.gov/docs/bioresource/colorectal/NCI-PBCF-HTB37_Caco-2_SOP-508.pdf http://tcpaportal.org/mclp/ http://www.cellresource.cn/fdetail.aspx?id=100 http://www.cellresource.cn/fdetail.aspx?id=634 http://www.cellresource.cn/fdetail.aspx?id=712 http://www.cellresource.cn/fdetail.aspx?id=905 http://www.cellresource.cn/fdetail.aspx?id=2112 http://www.cellresource.cn/fdetail.aspx?id=2170 | ||||||||||||||||||||||||||||||||||||||||||||||
Publications | PubMed=327080; DOI=10.1093/jnci/59.1.221 PubMed=833871; DOI=10.1093/jnci/58.2.209 PubMed=6935474; DOI=10.1093/jnci/66.2.239 PubMed=7459858 PubMed=3518877; DOI=10.3109/07357908609038260 PubMed=3349466 PubMed=2914637; DOI=10.1016/0016-5085(89)90897-4 PubMed=9294210; DOI=10.1073/pnas.94.19.10330 PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P PubMed=10737795; DOI=10.1073/pnas.97.7.3352 PubMed=11414198; DOI=10.1007/s004320000207 PubMed=12584437; DOI=10.1159/000068544 PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X PubMed=15316659; DOI=10.1007/s00018-004-4222-9 PubMed=15868485; DOI=10.1007/s10565-005-0085-6 PubMed=16418264; DOI=10.1073/pnas.0510146103 PubMed=16854228; DOI=10.1186/1476-4598-5-29 PubMed=18258742; DOI=10.1073/pnas.0712176105 PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192 PubMed=20606684; DOI=10.1038/sj.bjc.6605780 PubMed=20831567; DOI=10.1111/j.1582-4934.2010.01170.x PubMed=21607810; DOI=10.1208/s12248-011-9283-8 PubMed=23272949; DOI=10.1186/1755-8794-5-66 PubMed=23932154; DOI=10.1016/j.radonc.2013.06.032 PubMed=24042735; DOI=10.1038/oncsis.2013.35 PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013 PubMed=25960936; DOI=10.4161/21624011.2014.954893 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=25841592; DOI=10.1016/j.jprot.2015.03.019 PubMed=25926053; DOI=10.1038/ncomms8002 PubMed=26537799; DOI=10.1074/mcp.M115.051235 PubMed=26869432; DOI=10.1016/j.xphs.2015.10.030 PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 PubMed=28683746; DOI=10.1186/s12943-017-0691-y PubMed=29101300; DOI=10.15252/msb.20177701 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 PubMed=31981602; DOI=10.1016/j.tiv.2020.104773 | ||||||||||||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||||||||||||
Cell line collections | AddexBio; C0009009/29
ATCC; HTB-37 BCRJ; 0059 CCTCC; GDC0153 CLS; 300137/p1665_CaCo-2 DSMZ; ACC-169 ECACC; 09042001 ECACC; 86010202 IBRC; C10094 ICLC; HTL97023 IZSLER; BS TCL 87 KCB; KCB 200710YJ KCLB; 30037.1 NCBI_Iran; C139 RCB; RCB0988 | ||||||||||||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl614
CLDB; cl615 CLDB; cl616 CLDB; cl617 CLDB; cl618 CLDB; cl619 CLDB; cl621 CLDB; cl5174 CCLE; CACO2_LARGE_INTESTINE CCRID; 3111C0001CCC000100 CCRID; 3111C0002000000087 CCRID; 3131C0001000700066 CCRID; 3131C0001000700146 CCRID; 3142C0001000000137 CCRID; 3153C0001000000219 Cell_Model_Passport; SIDM00891 ColonAtlas; CACO2 DepMap; ACH-000003 FCS-free; 192-2-378-1-3-3 LINCS_LDP; LCL-1170 Lonza; 36 TOKU-E; 762 | ||||||||||||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0000195
CLO; CLO_0002172 CLO; CLO_0050627 EFO; EFO_0001099 MCCL; MCC:0000120 MeSH; D018938 | ||||||||||||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03473140
BioSample; SAMN05292461 BioSample; SAMN10989600 ENCODE; ENCBS311PHE ENCODE; ENCBS390JMI ENCODE; ENCBS391ENC ENCODE; ENCBS530YXL ENCODE; ENCBS700RKG ENCODE; ENCBS890JZY | ||||||||||||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307519
ChEMBL-Targets; CHEMBL614058 PharmacoDB; Caco2_161_2019 | ||||||||||||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-2706
GEO; GSM206450 GEO; GSM274711 GEO; GSM274712 GEO; GSM274725 GEO; GSM472900 GEO; GSM472933 GEO; GSM513908 GEO; GSM514182 GEO; GSM741244 GEO; GSM784006 GEO; GSM845394 GEO; GSM843481 GEO; GSM843482 GEO; GSM945162 GEO; GSM945203 GEO; GSM945206 GEO; GSM945236 GEO; GSM1006210 GEO; GSM1006211 GEO; GSM1006212 GEO; GSM1346866 GEO; GSM1374426 GEO; GSM1448160 GEO; GSM2549989 | ||||||||||||||||||||||||||||||||||||||||||||||
Metabolomic databases | MetaboLights; MTBLS227
MetaboLights; MTBLS328 | ||||||||||||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q5016050 | ||||||||||||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 720340
Cosmic; 873696 Cosmic; 875297 Cosmic; 876709 Cosmic; 887244 Cosmic; 889531 Cosmic; 948127 Cosmic; 948829 Cosmic; 983736 Cosmic; 995392 Cosmic; 1043805 Cosmic; 1122320 Cosmic; 1132564 Cosmic; 1132694 Cosmic; 1184081 Cosmic; 1187299 Cosmic; 1310931 Cosmic; 1466811 Cosmic; 1479620 Cosmic; 1524334 Cosmic; 1552180 Cosmic; 1676742 Cosmic; 1708415 Cosmic; 1803940 Cosmic; 1933015 Cosmic; 2036652 Cosmic; 2145574 Cosmic; 2156940 Cosmic; 2301543 Cosmic; 2301964 Cosmic; 2667879 Cosmic; 2800568 IARC_TP53; 21749 Progenetix; CVCL_0025 | ||||||||||||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD001550
PRIDE; PXD005354 PRIDE; PXD018357 | ||||||||||||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||||||||||||||||||||
Version number | 37 |