Cell line name | AN3-CA | ||||||||||||||||||||||||||||||||
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Synonyms | AN3_CA; AN3 CA; AN3 Ca; AN3CA; AN-3; AN3; Acanthosis Nigricans 3rd attempt-CArcinoma | ||||||||||||||||||||||||||||||||
Accession | CVCL_0028 | ||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: AN3-CA (RRID:CVCL_0028) | ||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: ERK genetic alteration cell panel (ATCC TCP-1033). Part of: MD Anderson Cell Lines Project. Part of: PTEN genetic alteration cell panel (ATCC TCP-1030). Doubling time: ~45-50 hours (CLS); ~55 hours (DSMZ). Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger). Omics: Array-based CGH. Omics: ATAC-seq. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis. | ||||||||||||||||||||||||||||||||
Sequence variations | Heterozygous for MAPK3 p.Pro373Ser (c.1117C>T) (ATCC).Heterozygous for PIK3R1 p.Arg557_Lys561delArgGluIleAspLysinsGln (c.1670_1681delGAGAAATTGACA) (ATCC).Homozygous for PTEN p.Arg130Glnfs*4 (c.389delG) (PubMed=20944090; ATCC).Heterozygous for TP53 p.Gly389Trp (c.1165G>T) (ClinVar=VCV000156517) (ATCC). | ||||||||||||||||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Endometrial adenocarcinoma (NCIt: C7359) Derived from metastatic site: Lymph node. | ||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Sex of cell | Female | ||||||||||||||||||||||||||||||||
Age at sampling | 55Y | ||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||
STR profile | Source(s): ATCC; CLS; Cosmic-CLP; DSMZ; PubMed=25877200 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
Web pages | http://www.proteinatlas.org/learn/cellines http://tcpaportal.org/mclp/ http://www.cellresource.cn/fdetail.aspx?id=866 | ||||||||||||||||||||||||||||||||
Publications | PubMed=14207855; DOI=10.1093/jnci/33.3.441 PubMed=327080; DOI=10.1093/jnci/59.1.221 PubMed=6220172 PubMed=3518877; DOI=10.3109/07357908609038260 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=20218740; DOI=10.1177/153303461000900207 PubMed=20944090; DOI=10.1126/scitranslmed.3001538 PubMed=22460905; DOI=10.1038/nature11003 PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 | ||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||
Cell line collections | ATCC; HTB-111
BCRJ; 0363 CCTCC; GDC0127 CLS; 300119/p494_AN3_Ca DSMZ; ACC-267 IZSLER; BS TCL 200 | ||||||||||||||||||||||||||||||||
Cell line databases/resources | CCLE; AN3CA_ENDOMETRIUM
CCRID; 3142C0001000000098 Cell_Model_Passport; SIDM00901 Cosmic-CLP; 910781 DepMap; ACH-000940 IGRhCellID; AN3CA LINCS_LDP; LCL-1499 TOKU-E; 543 | ||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0001771
CLO; CLO_0001722 EFO; EFO_0002110 | ||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03471092
BioSample; SAMN03473131 BioSample; SAMN03473336 BioSample; SAMN10988375 | ||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308708
ChEMBL-Targets; CHEMBL1075392 GDSC; 910781 PharmacoDB; AN3CA_63_2019 | ||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783 ArrayExpress; E-MTAB-2706 ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 GEO; GSM374970 GEO; GSM375429 GEO; GSM827494 GEO; GSM886869 GEO; GSM887934 GEO; GSM1669600 GEO; GSM3161710 GEO; GSM3161711 | ||||||||||||||||||||||||||||||||
Other | Wikidata; Q54749896 | ||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 687550
Cosmic; 699283 Cosmic; 713473 Cosmic; 713495 Cosmic; 809134 Cosmic; 846176 Cosmic; 871551 Cosmic; 889116 Cosmic; 910781 Cosmic; 980634 Cosmic; 1007162 Cosmic; 1057760 Cosmic; 1066221 Cosmic; 1070810 Cosmic; 1102376 Cosmic; 1105620 Cosmic; 1177683 Cosmic; 1223484 Cosmic; 1434192 Cosmic; 1576450 Cosmic; 1622894 Cosmic; 1696752 Cosmic; 2030460 Cosmic; 2646618 IARC_TP53; 21175 LiGeA; CCLE_574 Progenetix; CVCL_0028 | ||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||
Last entry update | 29-Oct-2020 | ||||||||||||||||||||||||||||||||
Version number | 30 |