Cellosaurus AN3-CA (CVCL_0028)

Cell line name AN3-CA
Synonyms AN3 CA; AN3 Ca; AN3CA; AN-3; AN3
Accession CVCL_0028
Resource Identification Initiative To cite this cell line use: AN3-CA (RRID:CVCL_0028)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: ERK genetic alteration cell panel (ATCC TCP-1033).
Part of: MD Anderson Cell Lines Project.
Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
Doubling time: ~55 hours (DSMZ).
Microsatellite instability: Instable (MSI-high) (Sanger).
Sequence variation: Heterozygous for MAPK3 p.Pro373Ser (ATCC).
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12,14,15 (ATCC; CLS; Cosmic-CLP; PubMed=25877200)
12,14 (DSMZ)
D13S31712,14
D16S53910,14 (ATCC; CLS; DSMZ; PubMed=25877200)
10,14,15 (Cosmic-CLP)
D18S5115,18
D21S1129,30
D3S135817
D5S81811,14
D7S8207,7.1,10 (ATCC; PubMed=25877200)
7,10 (CLS; Cosmic-CLP)
7.1,10 (DSMZ)
D8S117912,14
FGA23
Penta D9,11
Penta E9,16
TH019.3,10
TPOX8,10
vWA14,20
Web pages http://www.proteinatlas.org/learn/cellines
http://tcpaportal.org/mclp/
Publications

PubMed=14207855; DOI=10.1093/jnci/33.3.441
Dawe C.J., Banfield W.G., Morgan W.D., Slatick M.S., Curth H.O.
Growth in continuous culture, and in hamsters, of cells from a neoplasm associated with acanthosis nigricans.
J. Natl. Cancer Inst. 33:441-456(1964)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=6220172
Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; HTB-111
BCRJ; 0363
CLS; 300119/p494_AN3_Ca
DSMZ; ACC-267
IZSLER; BS TCL 200
Cell line databases/resources CCLE; AN3CA_ENDOMETRIUM
CCRID; 3142C0001000000098
Cosmic-CLP; 910781
GDSC; 910781
IGRhCellID; AN3CA
LINCS_LDP; LCL-1499
TOKU-E; 543
Ontologies BTO; BTO:0001771
CLO; CLO_0001722
EFO; EFO_0002110
Biological sample resources BioSample; SAMN03471092
BioSample; SAMN03473131
BioSample; SAMN03473336
Chemistry resources ChEMBL-Cells; CHEMBL3308708
ChEMBL-Targets; CHEMBL1075392
Gene expression databases GEO; GSM374970
GEO; GSM375429
GEO; GSM827494
GEO; GSM886869
GEO; GSM887934
GEO; GSM1669600
Polymorphism and mutation databases Cosmic; 687550
Cosmic; 699283
Cosmic; 713473
Cosmic; 713495
Cosmic; 809134
Cosmic; 846176
Cosmic; 871551
Cosmic; 889116
Cosmic; 910781
Cosmic; 980634
Cosmic; 1007162
Cosmic; 1057760
Cosmic; 1066221
Cosmic; 1070810
Cosmic; 1102376
Cosmic; 1105620
Cosmic; 1177683
Cosmic; 1223484
Cosmic; 1434192
Cosmic; 1576450
Cosmic; 1622894
Cosmic; 1696752
Cosmic; 2030460