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Cellosaurus AN3-CA (CVCL_0028)

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Cell line name AN3-CA
Synonyms AN3 CA; AN3 Ca; AN3CA; AN-3; AN3; Acanthosis Nigricans 3rd attempt-CArcinoma
Accession CVCL_0028
Resource Identification Initiative To cite this cell line use: AN3-CA (RRID:CVCL_0028)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: ERK genetic alteration cell panel (ATCC TCP-1033).
Part of: MD Anderson Cell Lines Project.
Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
Doubling time: ~45-50 hours (CLS); ~55 hours (DSMZ).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Array-based CGH.
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for MAPK3 p.Pro373Ser (c.1117C>T) (ATCC).
Heterozygous for PIK3R1 p.Arg557_Lys561delArgGluIleAspLysinsGln (c.1670_1681delGAGAAATTGACA) (ATCC).
Homozygous for PTEN p.Arg130Glnfs*4 (c.389delG) (PubMed=20944090; ATCC).
Heterozygous for TP53 p.Gly389Trp (c.1165G>T) (ATCC).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.36
Native American0
East Asian, North0.85
East Asian, South1.08
South Asian3.21
European, North62.96
European, South31.54
Disease Endometrial adenocarcinoma (NCIt: C7359)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12,14,15 (ATCC; CLS; Cosmic-CLP; PubMed=25877200)
12,14 (DSMZ)
D3S135817
D5S81811,14
D7S8207,7.1,10 (ATCC; PubMed=25877200)
7,10 (CLS; Cosmic-CLP)
7.1,10 (DSMZ)
D8S117912,14
D13S31712,14
D16S53910,14 (ATCC; CLS; DSMZ; PubMed=25877200)
10,14,15 (Cosmic-CLP)
D18S5115,18
D21S1129,30
FGA23
Penta D9,11
Penta E9,16
TH019.3,10
TPOX8,10
vWA14,20

Run an STR similarity search on this cell line
Web pages http://www.proteinatlas.org/learn/cellines
http://tcpaportal.org/mclp/
http://www.cellresource.cn/fdetail.aspx?id=866
Publications

PubMed=14207855; DOI=10.1093/jnci/33.3.441
Dawe C.J., Banfield W.G., Morgan W.D., Slatick M.S., Curth H.O.
Growth in continuous culture, and in hamsters, of cells from a neoplasm associated with acanthosis nigricans.
J. Natl. Cancer Inst. 33:441-456(1964)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=6220172
Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20218740; DOI=10.1177/153303461000900207
Wang Y., Yang D., Cogdell D., Hu L., Xue F., Broaddus R., Zhang W.
Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.
Technol. Cancer Res. Treat. 9:179-189(2010)

PubMed=20944090; DOI=10.1126/scitranslmed.3001538
Dedes K.J., Wetterskog D., Mendes-Pereira A.M., Natrajan R., Lambros M.B., Geyer F.C., Vatcheva R., Savage K., Mackay A., Lord C.J., Ashworth A., Reis-Filho J.S.
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
Sci. Transl. Med. 2:53ra75-53ra75(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; HTB-111
BCRJ; 0363
CCTCC; GDC0127
CLS; 300119/p494_AN3_Ca
DSMZ; ACC-267
IZSLER; BS TCL 200
Cell line databases/resources CCLE; AN3CA_ENDOMETRIUM
CCRID; 3142C0001000000098
Cell_Model_Passport; SIDM00901
Cosmic-CLP; 910781
DepMap; ACH-000940
GDSC; 910781
IGRhCellID; AN3CA
LINCS_LDP; LCL-1499
TOKU-E; 543
Ontologies BTO; BTO:0001771
CLO; CLO_0001722
EFO; EFO_0002110
Biological sample resources BioSample; SAMN03471092
BioSample; SAMN03473131
BioSample; SAMN03473336
BioSample; SAMN10988375
Chemistry resources ChEMBL-Cells; CHEMBL3308708
ChEMBL-Targets; CHEMBL1075392
PharmacoDB; AN3CA_63_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM374970
GEO; GSM375429
GEO; GSM827494
GEO; GSM886869
GEO; GSM887934
GEO; GSM1669600
Other Wikidata; Q54749896
Polymorphism and mutation databases Cosmic; 687550
Cosmic; 699283
Cosmic; 713473
Cosmic; 713495
Cosmic; 809134
Cosmic; 846176
Cosmic; 871551
Cosmic; 889116
Cosmic; 910781
Cosmic; 980634
Cosmic; 1007162
Cosmic; 1057760
Cosmic; 1066221
Cosmic; 1070810
Cosmic; 1102376
Cosmic; 1105620
Cosmic; 1177683
Cosmic; 1223484
Cosmic; 1434192
Cosmic; 1576450
Cosmic; 1622894
Cosmic; 1696752
Cosmic; 2030460
Cosmic; 2646618
IARC_TP53; 21175
LiGeA; CCLE_574
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number28