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Cellosaurus HeLa (CVCL_0030)

[Text version]

Cell line name HeLa
Synonyms HELA; Hela; He La; He-La; Henrietta Lacks cells; Helacyton gartleri
Accession CVCL_0030
Resource Identification Initiative To cite this cell line use: HeLa (RRID:CVCL_0030)
Comments Group: Space-flown cell line (cellonaut).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: African American.
Characteristics: HeLa has 5 five HPV18 integration sites: three on normal chromosomes 8 at 8q24 and two on derivative chromosomes, der(5)t(5;22;8)(q11;q11q13;q24) and der(22)t(8;22)(q24;q13).
Doubling time: 1.3 days (PubMed=29156801); ~48 hours (DSMZ).
Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Cell surface proteome.
Omics: CNV analysis.
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep membrane proteome analysis.
Omics: Deep phosphoproteome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Glycoproteome analysis by proteomics.
Omics: Myristoylated proteins analysis by proteomics.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Virome analysis using proteomics.
Anecdotal: The HeLa cell line which was established in February 1951 is the oldest human immortal cell line.
Anecdotal: The fascinating story of the HeLa cell line and of Henrietta Lacks from whom these cells originate are described in the book of Rebecca Skloot (CelloPub=CLPUB00377).
Anecdotal: The HeLa cell line and its story inspired Australian artist Cynthia Verspaget to embark in 2003 on a artistic project 'The Anarchy Cell Line' (TAnCL) where she mixed her blood with HeLa cells. This work later spawned a PhD thesis (CelloPub=CLPUB00376) where among other things she makes the observation that two main taxonomical distinctions present in the zombie, living/dead and human/nonhuman, are also present in the HeLa cell line.
Anecdotal: Was flown since the 1960s on at least ten different space missions: Korabl-Sputnik-2, Vostok-1, Vostok-4, Vostok-5 and Vostok-6, Voshkod 1 and Zond-5, Discoverer XVIII, Progress M-35/Mir and Shuttle STS-89.
Miscellaneous: HeLa is the most frequent contributor to cell lines contamination.
Derived from sampling site: Uterus; cervix.
HLA typing Source: PubMed=25960936
Class I
Class II
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.77
East Asian, North2.26
East Asian, South0
South Asian0
European, North19.45
European, South12.78
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2260 (1-5c-4)CVCL_2819 (11-4)CVCL_M629 (2563)
CVCL_2821 (4-11)CVCL_6872 (ACC-2)CVCL_6873 (ACC-3)
CVCL_8169 (ADLC-5M2)CVCL_8170 (AKI)CVCL_D631 (AO)
CVCL_1904 (AV3)CVCL_0164 (BCaP-37)CVCL_A033 (BCC-1/KMC)
CVCL_5492 (BEL-7402)CVCL_6568 (BEL-7404)CVCL_3360 (BGC-823)
CVCL_D280 (BrCA 5)CVCL_1858 (BT-B [Human HeLa contaminated cell line])CVCL_2322 (C16)
CVCL_UY83 (CaES-17)CVCL_M091 (CaOV)CVCL_8444 (CaVe)
CVCL_KS05 (CellSensor ESRE-bla HeLa)CVCL_KS08 (CellSensor HSE-bla HeLa)CVCL_KS75 (CellSensor MMTV-bla HeLa)
CVCL_KS77 (CellSensor T-REx FOXO3-DBE-bla HeLa)CVCL_KS76 (CellSensor T-REx NICD-CSL-bla HeLa)CVCL_0238 (Chang Liver)
CVCL_M022 (CM-319)CVCL_D297 (CMP [Human contaminated rectal cancer])CVCL_L115 (CMPII C2)
CVCL_6888 (CNE-1)CVCL_6889 (CNE-2)CVCL_8669 (D18T)
CVCL_D279 (DAPT)CVCL_8674 (Detroit 30A)CVCL_2436 (Detroit 6)
CVCL_8188 (Detroit 98)CVCL_8344 (EB33)CVCL_8686 (ElCo)
CVCL_8193 (EPLC-32M1)CVCL_8194 (EPLC-65H)CVCL_8351 (ESP-1)
CVCL_7262 (EUE)CVCL_8688 (F255A4)CVCL_1905 (FL)
CVCL_6395 (GH329)CVCL_6396 (GH354)CVCL_K171 (GH364)
CVCL_2254 (Girardi Heart)CVCL_3371 (GLC-82)CVCL_WL58 (GNM)
CVCL_7669 (H-494)CVCL_3334 (H1HeLa)CVCL_F269 (H454)
CVCL_D281 (HBT-3)CVCL_J652 (HBT-39b)CVCL_M619 (HCE)
CVCL_M624 (HEK)CVCL_1276 (HeLa 229)CVCL_3379 (HeLa 382)
CVCL_3380 (HeLa 422)CVCL_3381 (HeLa 432)CVCL_2933 (HeLa AG)
CVCL_2482 (HeLa B)CVCL_W341 (HeLa B-50)CVCL_W342 (HeLa C12)
CVCL_RX06 (HeLa C5G6)CVCL_RX07 (HeLa C6C3)CVCL_U339 (HeLa CD4+ Clone1022)
CVCL_X634 (HeLa CD4-Clone 6C)CVCL_2483 (HeLa DH)CVCL_ZF12 (HeLa E)
CVCL_ZM02 (HeLa H2B-GFP)CVCL_RJ62 (HeLa His10-SUMO-2 K0-Q87R)CVCL_9T98 (HeLa ICRP)
CVCL_W331 (HeLa JW36)CVCL_V312 (HeLa K11)CVCL_1922 (HeLa Kyoto)
CVCL_IM62 (HeLa LChm)CVCL_R965 (HeLa M)CVCL_1277 (HeLa NR1)
CVCL_DF41 (HeLa NucLight Green)CVCL_DF42 (HeLa NucLight Red)CVCL_2484 (HeLa Ohio)
CVCL_WH95 (HeLa P110)CVCL_UF72 (HeLa P75)CVCL_JA22 (HeLa PF)
CVCL_A9I6 (HeLa POM121-mCherry)CVCL_M763 (HeLa R19)CVCL_0058 (HeLa S3)
CVCL_KT28 (HeLa SilenciX ABL1)CVCL_KT29 (HeLa SilenciX ADAM17)CVCL_KT30 (HeLa SilenciX AKT1)
CVCL_KT31 (HeLa SilenciX APE1)CVCL_KT32 (HeLa SilenciX Argonaute 2)CVCL_KT33 (HeLa SilenciX Artemis)
CVCL_KT34 (HeLa SilenciX ATM)CVCL_KT35 (HeLa SilenciX ATP6AP2)CVCL_KT36 (HeLa SilenciX ATR)
CVCL_KT37 (HeLa SilenciX BAP1)CVCL_KT38 (HeLa SilenciX BAX)CVCL_KT39 (HeLa SilenciX BCL2)
CVCL_KT40 (HeLa SilenciX BID)CVCL_KT41 (HeLa SilenciX BLM)CVCL_KT42 (HeLa SilenciX BRCA1)
CVCL_KT43 (HeLa SilenciX BRCA2)CVCL_KT44 (HeLa SilenciX BTG2)CVCL_KT45 (HeLa SilenciX Caspase 3)
CVCL_KT46 (HeLa SilenciX Caspase 9)CVCL_KT47 (HeLa SilenciX CDK2)CVCL_KT27 (HeLa SilenciX Control)
CVCL_KT48 (HeLa SilenciX COX2)CVCL_KT49 (HeLa SilenciX CTNNB1)CVCL_KT50 (HeLa SilenciX DDB2)
CVCL_KT51 (HeLa SilenciX DIABLO)CVCL_KT52 (HeLa SilenciX DNA-PKcs)CVCL_KT53 (HeLa SilenciX ERCC1)
CVCL_KT54 (HeLa SilenciX Exportin 5)CVCL_KT55 (HeLa SilenciX FADD)CVCL_KT56 (HeLa SilenciX FancD2)
CVCL_KT57 (HeLa SilenciX FEN1)CVCL_KT58 (HeLa SilenciX GNAQ)CVCL_KT59 (HeLa SilenciX GPS1)
CVCL_KT60 (HeLa SilenciX GPX8)CVCL_KT61 (HeLa SilenciX HDAC1)CVCL_KT62 (HeLa SilenciX HIF1A)
CVCL_KT63 (HeLa SilenciX Hif2alpha)CVCL_KT64 (HeLa SilenciX HMG1L1)CVCL_KT65 (HeLa SilenciX HMGB1)
CVCL_KT66 (HeLa SilenciX HR23A)CVCL_KT67 (HeLa SilenciX HR23B)CVCL_KT68 (HeLa SilenciX HuR)
CVCL_KT69 (HeLa SilenciX KIN17)CVCL_KT70 (HeLa SilenciX LigI)CVCL_KT71 (HeLa SilenciX LigIII)
CVCL_KT72 (HeLa SilenciX LigIV)CVCL_KT73 (HeLa SilenciX MAPK1)CVCL_KT74 (HeLa SilenciX MCU)
CVCL_KT75 (HeLa SilenciX MLH1)CVCL_KT76 (HeLa SilenciX MRE11)CVCL_KT77 (HeLa SilenciX MSH2)
CVCL_KT78 (HeLa SilenciX MTERFD2)CVCL_KT79 (HeLa SilenciX NBS1)CVCL_KT80 (HeLa SilenciX NCL)
CVCL_KT81 (HeLa SilenciX NEIL1)CVCL_KT82 (HeLa SilenciX NF1)CVCL_KT83 (HeLa SilenciX NRF2)
CVCL_KT84 (HeLa SilenciX NUDCD1)CVCL_KT85 (HeLa SilenciX Ogg1)CVCL_KT86 (HeLa SilenciX p21)
CVCL_KT87 (HeLa SilenciX p53)CVCL_KT88 (HeLa SilenciX PARG)CVCL_KT89 (HeLa SilenciX PARP1)
CVCL_KT90 (HeLa SilenciX PARP2)CVCL_KT91 (HeLa SilenciX PCNA)CVCL_KT92 (HeLa SilenciX PIK3CD)
CVCL_KT93 (HeLa SilenciX PKCalpha)CVCL_KT94 (HeLa SilenciX PolH)CVCL_KT95 (HeLa SilenciX PRDX1)
CVCL_KT96 (HeLa SilenciX PRDX2)CVCL_KT97 (HeLa SilenciX Rad50)CVCL_KT98 (HeLa SilenciX Rad54A)
CVCL_KT99 (HeLa SilenciX Rad54B)CVCL_KU00 (HeLa SilenciX RB)CVCL_KU01 (HeLa SilenciX RHOQ)
CVCL_KU02 (HeLa SilenciX Septin 9)CVCL_KU03 (HeLa SilenciX SIRT1)CVCL_KU04 (HeLa SilenciX SNAPIN)
CVCL_KU05 (HeLa SilenciX SOD2)CVCL_KU06 (HeLa SilenciX SORCIN)CVCL_KU07 (HeLa SilenciX SSX2IP)
CVCL_KU08 (HeLa SilenciX STAT1)CVCL_KU09 (HeLa SilenciX THTPA)CVCL_KU10 (HeLa SilenciX TMSB4X)
CVCL_KU11 (HeLa SilenciX TNFR1)CVCL_KU12 (HeLa SilenciX TP53BP1)CVCL_KU13 (HeLa SilenciX TRAILR2)
CVCL_KU14 (HeLa SilenciX TRIO)CVCL_KU15 (HeLa SilenciX TXNRD2)CVCL_KU16 (HeLa SilenciX USP11)
CVCL_KU17 (HeLa SilenciX USP14)CVCL_KU18 (HeLa SilenciX USP19)CVCL_KU19 (HeLa SilenciX USP7)
CVCL_KU20 (HeLa SilenciX USP9X)CVCL_KU21 (HeLa SilenciX WDR8)CVCL_KU22 (HeLa SilenciX WIP1)
CVCL_KU23 (HeLa SilenciX XIAP)CVCL_KU24 (HeLa SilenciX XLF)CVCL_KU25 (HeLa SilenciX XPA)
CVCL_KU26 (HeLa SilenciX XPC)CVCL_KU27 (HeLa SilenciX XPF)CVCL_KU28 (HeLa SilenciX XRCC1)
CVCL_KU29 (HeLa SilenciX XRCC4)CVCL_S026 (HeLa SimpleCell O-GalNAc)CVCL_R768 (HeLa SS6)
CVCL_V352 (HeLa Tet-Off)CVCL_IY74 (HeLa Tet-On)CVCL_V353 (HeLa Tet-On 3G)
CVCL_KU41 (HeLa Tet-On Advanced)CVCL_2935 (HeLa TG)CVCL_2936 (HeLa TG Cap)
CVCL_9497 (HeLa TK-)CVCL_V354 (HeLa tTS)CVCL_6E62 (HeLa(tTA)1)
CVCL_4776 (HeLa-80)CVCL_VU54 (HeLa-AC free)CVCL_9493 (HeLa-APL)
CVCL_W646 (HeLa-APOBEC3G)CVCL_XE39 (Hela-Cas9-527)CVCL_XE40 (Hela-Cas9-528)
CVCL_XE41 (Hela-Cas9-529)CVCL_XE42 (Hela-Cas9-530)CVCL_XE43 (Hela-Cas9-531)
CVCL_XE44 (Hela-Cas9-532)CVCL_XE45 (Hela-Cas9-533)CVCL_XE46 (Hela-Cas9-534)
CVCL_XE47 (Hela-Cas9-535)CVCL_XE48 (Hela-Cas9-536)CVCL_XE49 (Hela-Cas9-537)
CVCL_H339 (HeLa-CD14)CVCL_WN71 (HeLa-EM2-11ht)CVCL_1H14 (HeLa-env-Eli)
CVCL_1H15 (HeLa-env-IIIB)CVCL_1H16 (HeLa-env-Mal)CVCL_VJ28 (HeLa-G63)
CVCL_5J41 (HeLa-luc)CVCL_YA88 (HeLa-Luc)CVCL_D259 (HeLa-MAGI)
CVCL_GR67 (HeLa-Munc18b)CVCL_1J89 (HeLa-RR-B51S)CVCL_S495 (HeLa-T4+)
CVCL_1D87 (HeLa-T8+)CVCL_1H25 (HeLa-tat-III)CVCL_9U03 (HeLa-UGT1A9)
CVCL_4Z13 (HeLa.EpoA9)CVCL_4Z14 (HeLa.EpoB1.8)CVCL_2937 (HeLa.P3)
CVCL_JG57 (HeLa/CMV-Luc)CVCL_JZ15 (HeLa/crmA)CVCL_C869 (HeLa/DDP)
CVCL_E070 (HeLa/Fucci)CVCL_VM98 (HeLa/Fucci(CA)2)CVCL_VM99 (HeLa/Fucci(SCA)2)
CVCL_U187 (HeLa/Fucci2)CVCL_JY89 (HeLa/GFP)CVCL_UG45 (HeLa/GSTP1)
CVCL_2939 (HeLa/MMTV-luc)CVCL_KS39 (HeLa/NFAT-luc)CVCL_KS40 (HeLa/NFkB-luc)
CVCL_KS42 (HeLa/SRF-luc)CVCL_KS41 (HeLa/STAT1-luc)CVCL_KS43 (HeLa/STAT3-luc)
CVCL_2485 (HeLa9903)CVCL_A9H3 (HeLap121G)CVCL_B053 (HeLaRC32)
CVCL_1278 (HeLaSF)CVCL_WI87 (HELN)CVCL_1906 (HEp-2)
CVCL_WI90 (HGELN)CVCL_8231 (HL111783)CVCL_X685 (HL2/3)
CVCL_8232 (HL3T1)CVCL_X688 (HLfB)CVCL_KB15 (HLR)
CVCL_8164 (HLtat)CVCL_U968 (HML-Gb3)CVCL_8233 (HMV-I)
CVCL_6868 (HO-8910)CVCL_8446 (HPC-36M)CVCL_2505 (HR5)
CVCL_2517 (HSG)CVCL_B032 (HSY)CVCL_WU77 (HT [Human HeLa contaminated cell line])
CVCL_2523 (HtTA-1)CVCL_8283 (HuKo39)CVCL_8357 (HuL-1)
CVCL_M861 (Hut)CVCL_8245 (IMC-2)CVCL_8246 (IMC-3)
CVCL_8247 (IMC-4)CVCL_1907 (Intestine 407)CVCL_2965 (J-111)
CVCL_3990 (J-96)CVCL_M093 (JHC)CVCL_8362 (JTC-17)
CVCL_A034 (JTC-3)CVCL_0372 (KB)CVCL_7963 (KCC-MS871)
CVCL_7966 (KCC-TCM901)CVCL_D283 (KP-P1)CVCL_4714 (KU-7)
CVCL_6926 (L-02)CVCL_1908 (L-132)CVCL_ZJ09 (LanthaScreen c-Jun (1-79) HeLa)
CVCL_8438 (Led-T1)CVCL_YJ81 (LINTERNA HeLa)CVCL_6929 (LTEP-a2)
CVCL_M631 (LU)CVCL_8892 (Lu 106)CVCL_M094 (M10T)
CVCL_8261 (MA-160)CVCL_M627 (MAC-21)CVCL_5328 (MaTu)
CVCL_5331 (MC4000)CVCL_8264 (Minnesota EE)CVCL_4243 (MS [Human HeLa contaminated cell line])
CVCL_0441 (MT-1 [Human contaminated breast cancer])CVCL_0461 (NCTC 2544)CVCL_8156 (NCTC 3075)
CVCL_J350 (OE)CVCL_M621 (OF)CVCL_LI06 (OMC685)
CVCL_8399 (OST)CVCL_1H21 (P4 MAGI CCR5+)CVCL_4888 (PC-93)
CVCL_6859 (QGY-7701)CVCL_6715 (QGY-7703)CVCL_6944 (QSG-7701)
CVCL_0U46 (RPMI-4788)CVCL_8910 (SA-4)CVCL_1677 (SBC-2 [Human contaminated bladder carcinoma])
CVCL_1680 (SBC-7 [Human contaminated bladder carcinoma])CVCL_0520 (SGC-7901)CVCL_M622 (SH-2 [Human contaminated breast cancer])
CVCL_M383 (SH-3)CVCL_0534 (SMMC-7721)CVCL_8273 (SQ-5)
CVCL_M858 (T-1)CVCL_M092 (T-9)CVCL_D587 (T-REx-HeLa)
CVCL_1U15 (T1 [Human contaminated neural stem cell])CVCL_6851 (Tca8113)CVCL_WU76 (TLouaR)
CVCL_VL15 (TSCCa)CVCL_8275 (TuWi)CVCL_B478 (TZM-bl)
CVCL_1909 (WISH)CVCL_2764 (WKD)CVCL_0581 (WRL 68)
CVCL_8017 (YCU-H891)CVCL_RL03 (Z-HL16C)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; PubMed=11416159; PubMed=25877200; PubMed=29156801; RCB; TKG

D13S31712 (Cosmic-CLP; RCB)
12,13.3 (AddexBio; ATCC; CCRID; DSMZ; JCRB; KCLB; PubMed=25877200; PubMed=29156801; TKG)
12,14 (ECACC)
13,13.3 (CLS)
D21S1127 (CLS)
27,28 (CCRID; DSMZ; PubMed=25877200)
Penta D8 (CLS)
8,15 (CCRID; DSMZ; PubMed=25877200)
Penta E7,17

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/HeLa

Gey G.O., Coffman W.D., Kubicek M.T.
Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium.
Cancer Res. 12:264-265(1952)

PubMed=13052828; DOI=10.1084/jem.97.5.695
Scherer W.F., Syverton J.T., Gey G.O.
Studies on the propagation in vitro of poliomyelitis viruses. IV Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix.
J. Exp. Med. 97:695-710(1953)

Moore A.E., Sabachewsky L., Toolan H.W.
Culture characteristics of four permanent lines of human cancer cells.
Cancer Res. 15:598-602(1955)

PubMed=16589695; DOI=10.1073/pnas.41.7.432
Puck T.T., Marcus P.I.
A rapid method for viable cell titration and clone production with HeLa cells in tissue culture: the use of X-irradiated cells to supply conditioning factors.
Proc. Natl. Acad. Sci. U.S.A. 41:432-437(1955)

Katzberg A.A.
The effect of space flights on living human cells aboard Discoverer XVIII.
Tech. Doc. Rep. SAMTDR USAF Sch. Aerosp. Med. 62:43.1-43.4(1962)

PubMed=14185313; DOI=10.1126/science.146.3641.241
Cell Culture Collection Committee
Animal cell strains. The Cell Culture Collection Committee has assembled and certified 23 strains of animal cells.
Science 146:241-243(1964)

PubMed=5668122; DOI=10.3181/00379727-128-33119
Peterson W.D. Jr., Stulberg C.S., Swanborg N.K., Robinson A.R.
Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures determined by sucrose-agar gel and cellulose acetate zymograms.
Proc. Soc. Exp. Biol. Med. 128:772-776(1968)

PubMed=4942173; DOI=10.1097/00006250-197112000-00028
Jones H.W. Jr., McKusick V.A., Harper P.S., Wuu K.-D.
George Otto Gey (1899-1970). The HeLa cell and a reappraisal of its origin.
Obstet. Gynecol. 38:945-949(1971)

Biedler J.L.
Chromosome abnormalities in human tumor cells in culture.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975)

PubMed=6256643; DOI=10.1038/288724a0
Day R.S. III, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A., Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.
Nature 288:724-727(1980)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=6358339; DOI=10.1093/jhmas/38.4.415
Brown R.W., Henderson J.H.M.
The mass production and distribution of HeLa cells at Tuskegee Institute, 1953-55.
J. Hist. Med. Allied Sci. 38:415-431(1983)

PubMed=6401685; DOI=10.1007/BF02617989
Halton D.M., Peterson W.D. Jr., Hukku B.
Cell culture quality control by rapid isoenzymatic characterization.
In Vitro 19:16-24(1983)

PubMed=6825208; DOI=10.1093/carcin/4.2.199
Yarosh D.B., Foote R.S., Mitra S., Day R.S. III
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.
Carcinogenesis 4:199-205(1983)

PubMed=2983228; DOI=10.1038/314111a0
Schwarz E., Freese U.-K., Gissmann L., Mayer W., Roggenbuck B., Stremlau A., zur Hausen H.
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells.
Nature 314:111-114(1985)

Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

Gold M.
A conspiracy of cells. One woman's immortal legacy and the medical scandal it caused.
(In) ISBN 9780887060991; pp.1-171; State University of New York Press; Albany (1986)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3028716; DOI=10.1159/000132342
Popescu N.C., DiPaolo J.A., Amsbaugh S.C.
Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes.
Cytogenet. Cell Genet. 44:58-62(1987)

PubMed=3180844; DOI=10.1159/000132579
Chen T.-R.
Re-evaluation of HeLa, HeLa S3, and HEp-2 karyotypes.
Cytogenet. Cell Genet. 48:19-24(1988)

PubMed=3371749; DOI=10.1016/0090-8258(88)90029-7
Grenman S.E., Shapira A., Carey T.E.
In vitro response of cervical cancer cell lines CaSki, HeLa, and ME-180 to the antiestrogen tamoxifen.
Gynecol. Oncol. 30:228-238(1988)

PubMed=1522048; DOI=10.1007/BF02634140
Kataoka E., Honma M., Ohnishi K., Sofuni T., Mizusawa H.
Application of highly polymorphic DNA markers to the identification of HeLa cell sublines.
In Vitro Cell. Dev. Biol. Anim. 28:553-556(1992)

PubMed=8380785; DOI=10.1006/gyno.1993.1016
Iwasaka T., Oh-uchida M., Matsuo N., Yokoyama M., Fukuda K., Hara K., Fukuyama K., Hori K., Sugimori H.
Correlation between HPV positivity and state of the p53 gene in cervical carcinoma cell lines.
Gynecol. Oncol. 48:104-109(1993)

Macville M., Schrock E., Padilla-Nash H.M., Keck C., Ghadimi B.M., Zimonjic D.B., Popescu N.C., Ried T.
Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping.
Cancer Res. 59:141-150(1999)

PubMed=10423141; DOI=10.1099/0022-1317-80-7-1725
Meissner J.D.
Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines.
J. Gen. Virol. 80:1725-1733(1999)

PubMed=12001993; DOI=10.1038/nrc775
Masters J.R.W.
HeLa cells 50 years on: the good, the bad and the ugly.
Nat. Rev. Cancer 2:315-319(2002)

PubMed=12793746; DOI=10.1269/jrr.43.s133
Ohnishi T., Ohnishi K., Takahashi A., Taniguchi Y., Sato M., Nakano T., Nagaoka S.
Detection of DNA damage induced by space radiation in Mir and space shuttle.
J. Radiat. Res. 43:S133-S136(2002)

PubMed=12661003; DOI=10.1002/gcc.10196
Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U., Santibanez-Koref M.-F., Schlag P.M., Scherneck S.
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.
Genes Chromosomes Cancer 37:29-35(2003)

PubMed=15302935; DOI=10.1073/pnas.0404720101
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

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Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathol. Res. Pract. 201:109-115(2005)

PubMed=17311676; DOI=10.1186/1471-2164-8-53
Kloth J.N., Oosting J., van Wezel T., Szuhai K., Knijnenburg J., Gorter A., Kenter G.G., Fleuren G.J., Jordanova E.S.
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.
BMC Genomics 8:53-53(2007)

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Lucey B.P., Nelson-Rees W.A., Hutchins G.M.
Henrietta Lacks, HeLa cells, and cell culture contamination.
Arch. Pathol. Lab. Med. 133:1463-1467(2009)

Skloot R.
The immortal life of Henrietta Lacks.
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Javitt G.
Why not take all of me? Reflections on the immortal life of Henrietta Lacks and the status of participants in research using human specimens.
Minn. J. Law Sci. Technol. 11:713-755(2010)

PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022
Karger A., Bettin B., Lenk M., Mettenleiter T.C.
Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing.
J. Virol. Methods 164:116-121(2010)

PubMed=21269460; DOI=10.1186/1752-0509-5-17
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol. 5:17-17(2011)

PubMed=22068331; DOI=10.1038/msb.2011.81
Nagaraj N., Wisniewski J.R., Geiger T., Cox J., Kircher M., Kelso J., Paabo S., Mann M.
Deep proteome and transcriptome mapping of a human cancer cell line.
Mol. Syst. Biol. 7:548-548(2011)

PubMed=21937730; DOI=10.1074/mcp.M111.011429
Boisvert F.-M., Ahmad Y., Gierlinski M., Charriere F., Lamont D., Scott M., Barton G., Lamond A.I.
A quantitative spatial proteomics analysis of proteome turnover in human cells.
Mol. Cell. Proteomics 11:M111.011429-M111.011429(2012)

PubMed=22278370; DOI=10.1074/mcp.M111.014050
Geiger T., Wehner A., Schaab C., Cox J., Mann M.
Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins.
Mol. Cell. Proteomics 11:M111.014050-M111.014050(2012)

Pultarova T.
HeLa cells: immortal space travellers.
Space Saf. Mag. 7:10-12(2013)

PubMed=23205564; DOI=10.1021/pr300859k
Malerod H., Graham R.L.J., Sweredoski M.J., Hess S.
Comprehensive profiling of N-linked glycosylation sites in HeLa cells using hydrazide enrichment.
J. Proteome Res. 12:248-259(2013)

PubMed=23336012; DOI=10.1371/journal.pone.0054672
Horvat T., Dezeljin M., Redzic I., Barisic D., Herak Bosnar M., Lauc G., Zoldos V.
Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors.
PLoS ONE 8:E54672-E54672(2013)

PubMed=23925224; DOI=10.1038/500141a
Hudson K.L., Collins F.S.
Biospecimen policy: family matters.
Nature 500:141-142(2013)

PubMed=23925245; DOI=10.1038/nature12064
Adey A., Burton J.N., Kitzman J.O., Hiatt J.B., Lewis A.P., Martin B.K., Qiu R., Lee C., Shendure J.
The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line.
Nature 500:207-211(2013)

PubMed=24134916; DOI=10.1186/1755-8166-6-44
McCormack A., Fan J.L., Duesberg M., Bloomfield M., Fiala C., Duesberg P.
Individual karyotypes at the origins of cervical carcinomas.
Mol. Cytogenet. 6:44-44(2013)

PubMed=24618588; DOI=10.1371/journal.pone.0091433
Chernobrovkin A.L., Zubarev R.A.
Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins.
PLoS ONE 9:E91433-E91433(2014)

PubMed=24696503; DOI=10.1074/mcp.M113.035170
Guo X., Trudgian D.C., Lemoff A., Yadavalli S., Mirzaei H.
Confetti: a multiprotease map of the HeLa proteome for comprehensive proteomics.
Mol. Cell. Proteomics 13:1573-1584(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

Verspaget C.J.
Unruly bodies: monstrous readings of biotechnology.
Thesis PhD (2015), Curtin University, Australia

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25807930; DOI=10.1002/anie.201500342
Broncel M., Serwa R.A., Ciepla P., Krause E., Dallman M.J., Magee A.I., Tate E.W.
Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.
Angew. Chem. Int. Ed. 54:5948-5951(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

PubMed=26554430; DOI=10.1021/acs.analchem.5b03639
Dimayacyac-Esleta B.R., Tsai C.-F., Kitata R.B., Lin P.-Y., Choong W.-K., Lin T.-D., Wang Y.-T., Weng S.-H., Yang P.-C., Arco S.D., Sung T.-Y., Chen Y.-J.
Rapid high-pH reverse phase stagetip for sensitive small-scale membrane proteomic profiling.
Anal. Chem. 87:12016-12023(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28078501; DOI=10.1007/s11626-016-0128-8
Ambrose C.T.
The Tissue Culture Laboratory of Dr. George Otto Gey 60 yrs ago as recalled by a former student.
In Vitro Cell. Dev. Biol. Anim. 53:467-473(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
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PubMed=28601559; DOI=10.1016/j.cels.2017.05.009
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Oncotarget 8:86369-86383(2017)

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Cell line collections AddexBio; C0008001/44
ATCC; CRL-7923 - Discontinued
BCRC; 60005
BCRJ; 0100
CLS; 300194/p772_HeLa
ECACC; 93021013
ICLC; HTL95023
KCB; KCB 86019YJ
KCB; KCB 90024YJ
KCLB; 10002
NCBI_Iran; C115
NIH-ARP; 153-364
RCB; RCB0007
RCB; RCB3680
TKG; TKG 0331
Cell line databases/resources CLDB; cl1594
CLDB; cl1595
CLDB; cl1596
CLDB; cl1597
CLDB; cl1599
CLDB; cl1600
CLDB; cl1601
CLDB; cl1603
CCRID; 3111C0001CCC000011
CCRID; 3111C0001CCC000332
CCRID; 3111C0002000000057
CCRID; 3131C0001000700019
CCRID; 3131C0001000700187
CCRID; 3142C0001000000009
CCRID; 3153C0001000000007
Cell_Model_Passport; SIDM00846
Cosmic-CLP; 1298134
DepMap; ACH-001086
FCS-free; 44-2-47-1-8-9
LINCS_HMS; 50061
Lonza; 51
TOKU-E; 1434
Ontologies BTO; BTO:0000567
CLO; CLO_0003684
CLO; CLO_0050910
EFO; EFO_0001185
MCCL; MCC:0000219
MeSH; D006367
Biological sample resources BioSample; SAMN03471148
BioSample; SAMN03472333
BioSample; SAMN10989629
Chemistry resources ChEMBL-Cells; CHEMBL3308376
ChEMBL-Targets; CHEMBL399
GDSC; 1298134
PharmacoDB; HeLa_536_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM113863
GEO; GSM226739
GEO; GSM226875
GEO; GSM253298
GEO; GSM436128
GEO; GSM436129
GEO; GSM501788
GEO; GSM723055
GEO; GSM723056
GEO; GSM1088663
GEO; GSM1088664
GEO; GSM1088665
GEO; GSM1088666
GEO; GSM1374528
GEO; GSM1669875
Other Wikidata; Q847482
Polymorphism and mutation databases Cosmic; 760219
Cosmic; 760490
Cosmic; 801357
Cosmic; 809231
Cosmic; 877477
Cosmic; 911999
Cosmic; 925354
Cosmic; 928907
Cosmic; 944113
Cosmic; 1019309
Cosmic; 1057766
Cosmic; 1071911
Cosmic; 1131525
Cosmic; 1193029
Cosmic; 1201779
Cosmic; 1324208
Cosmic; 1336880
Cosmic; 1571796
Cosmic; 2301539
Cosmic; 2660190
Cosmic; 2750874
Cosmic; 2791019
Cosmic; 2816214
Progenetix; CVCL_0030
Proteomic databases PRIDE; PRD000007
PRIDE; PRD000032
PRIDE; PRD000123
PRIDE; PRD000124
PRIDE; PRD000345
PRIDE; PRD000376
PRIDE; PRD000525
PRIDE; PRD000526
PRIDE; PRD000527
PRIDE; PXD000013
PRIDE; PXD000243
PRIDE; PXD000252
PRIDE; PXD000279
PRIDE; PXD000396
PRIDE; PXD000474
PRIDE; PXD000589
PRIDE; PXD000661
PRIDE; PXD000680
PRIDE; PXD000759
PRIDE; PXD000883
PRIDE; PXD000895
PRIDE; PXD000900
PRIDE; PXD000953
PRIDE; PXD000954
PRIDE; PXD000999
PRIDE; PXD001047
PRIDE; PXD001118
PRIDE; PXD001154
PRIDE; PXD001175
PRIDE; PXD001249
PRIDE; PXD001258
PRIDE; PXD001259
PRIDE; PXD001278
PRIDE; PXD001305
PRIDE; PXD001374
PRIDE; PXD001381
PRIDE; PXD001396
PRIDE; PXD001441
PRIDE; PXD001541
PRIDE; PXD001548
PRIDE; PXD001574
PRIDE; PXD001660
PRIDE; PXD001781
PRIDE; PXD001798
PRIDE; PXD001805
PRIDE; PXD001806
PRIDE; PXD001810
PRIDE; PXD001863
PRIDE; PXD001907
PRIDE; PXD002001
PRIDE; PXD002039
PRIDE; PXD002066
PRIDE; PXD002252
PRIDE; PXD002277
PRIDE; PXD002378
PRIDE; PXD002383
PRIDE; PXD002395
PRIDE; PXD002572
PRIDE; PXD002591
PRIDE; PXD002704
PRIDE; PXD002844
PRIDE; PXD002880
PRIDE; PXD003186
PRIDE; PXD003209
PRIDE; PXD003258
PRIDE; PXD003370
PRIDE; PXD003503
PRIDE; PXD003530
PRIDE; PXD003560
PRIDE; PXD003792
PRIDE; PXD003813
PRIDE; PXD003909
PRIDE; PXD003913
PRIDE; PXD003917
PRIDE; PXD003924
PRIDE; PXD004182
PRIDE; PXD004271
PRIDE; PXD004273
PRIDE; PXD004452
PRIDE; PXD004613
PRIDE; PXD004736
PRIDE; PXD004900
PRIDE; PXD004914
PRIDE; PXD004933
PRIDE; PXD004934
PRIDE; PXD004940
PRIDE; PXD004995
PRIDE; PXD005018
PRIDE; PXD005107
PRIDE; PXD005181
PRIDE; PXD005346
PRIDE; PXD005349
PRIDE; PXD005366
PRIDE; PXD005509
PRIDE; PXD005572
PRIDE; PXD005712
PRIDE; PXD005955
PRIDE; PXD006112
PRIDE; PXD006293
PRIDE; PXD012188
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number35