ID   MCF-7
AC   CVCL_0031
SY   MCF 7; MCF.7; MCF7; Michigan Cancer Foundation-7; ssMCF-7; ssMCF7; MCF7/WT; IBMF-7; MCF7-CTRL
DR   BTO; BTO:0000093
DR   CLO; CLO_0007601
DR   CLO; CLO_0007605
DR   CLO; CLO_0007606
DR   CLO; CLO_0050868
DR   EFO; EFO_0001203
DR   MCCL; MCC:0000307
DR   CLDB; cl3366
DR   CLDB; cl3367
DR   CLDB; cl3368
DR   CLDB; cl3369
DR   CLDB; cl3370
DR   CLDB; cl3371
DR   CLDB; cl3372
DR   CLDB; cl3373
DR   CLDB; cl3375
DR   AddexBio; C0006008/402
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-TABM-157
DR   ArrayExpress; E-TABM-244
DR   ATCC; CRL-12584
DR   ATCC; HTB-22
DR   BCRC; 60436
DR   BCRJ; 0162
DR   BioSample; SAMN01821575
DR   BioSample; SAMN01821646
DR   BioSample; SAMN01821698
DR   BioSample; SAMN03473276
DR   BioSample; SAMN05292458
DR   BioSample; SAMN10988179
DR   CCLE; MCF7_BREAST
DR   CCRID; 3111C0001CCC000013
DR   CCRID; 3111C0001CCC000328
DR   CCRID; 3131C0001000700074
DR   CCRID; 3142C0001000000054
DR   CCTCC; GDC0055
DR   Cell_Model_Passport; SIDM00148
DR   ChEMBL-Cells; CHEMBL3308403
DR   ChEMBL-Targets; CHEMBL387
DR   CLS; 300273/p2720_MCF-7
DR   Cosmic; 687490
DR   Cosmic; 755293
DR   Cosmic; 809239
DR   Cosmic; 871143
DR   Cosmic; 875876
DR   Cosmic; 877449
DR   Cosmic; 894096
DR   Cosmic; 897419
DR   Cosmic; 904373
DR   Cosmic; 905946
DR   Cosmic; 912001
DR   Cosmic; 921976
DR   Cosmic; 923059
DR   Cosmic; 934534
DR   Cosmic; 944293
DR   Cosmic; 947352
DR   Cosmic; 949189
DR   Cosmic; 970089
DR   Cosmic; 979723
DR   Cosmic; 991328
DR   Cosmic; 997916
DR   Cosmic; 1000123
DR   Cosmic; 1010932
DR   Cosmic; 1017161
DR   Cosmic; 1018463
DR   Cosmic; 1019310
DR   Cosmic; 1046936
DR   Cosmic; 1047712
DR   Cosmic; 1066224
DR   Cosmic; 1071901
DR   Cosmic; 1092612
DR   Cosmic; 1102382
DR   Cosmic; 1136341
DR   Cosmic; 1152527
DR   Cosmic; 1175832
DR   Cosmic; 1176603
DR   Cosmic; 1176648
DR   Cosmic; 1183770
DR   Cosmic; 1287893
DR   Cosmic; 1289391
DR   Cosmic; 1305382
DR   Cosmic; 1308991
DR   Cosmic; 1312369
DR   Cosmic; 1326278
DR   Cosmic; 1434950
DR   Cosmic; 1436031
DR   Cosmic; 1477426
DR   Cosmic; 1481420
DR   Cosmic; 1523770
DR   Cosmic; 1524349
DR   Cosmic; 1571788
DR   Cosmic; 1603215
DR   Cosmic; 1609459
DR   Cosmic; 1945860
DR   Cosmic; 1995500
DR   Cosmic; 1998454
DR   Cosmic; 2162161
DR   Cosmic; 2165024
DR   Cosmic; 2301233
DR   Cosmic; 2301526
DR   Cosmic; 2307194
DR   Cosmic; 2318370
DR   Cosmic; 2361358
DR   Cosmic; 2525755
DR   Cosmic; 2553502
DR   Cosmic; 2560248
DR   Cosmic; 2668278
DR   Cosmic-CLP; 905946
DR   DepMap; ACH-000019
DR   DSMZ; ACC-115
DR   ECACC; 86012803
DR   ENCODE; ENCBS000AAA
DR   ENCODE; ENCBS000RXG
DR   ENCODE; ENCBS001AAA
DR   ENCODE; ENCBS017ENC
DR   ENCODE; ENCBS028FSB
DR   ENCODE; ENCBS034XKZ
DR   ENCODE; ENCBS035QUK
DR   ENCODE; ENCBS035TSV
DR   ENCODE; ENCBS036ENC
DR   ENCODE; ENCBS037ENC
DR   ENCODE; ENCBS050QMU
DR   ENCODE; ENCBS053YJT
DR   ENCODE; ENCBS056AAA
DR   ENCODE; ENCBS094ENC
DR   ENCODE; ENCBS095ENC
DR   ENCODE; ENCBS096ENC
DR   ENCODE; ENCBS097ENC
DR   ENCODE; ENCBS098ENC
DR   ENCODE; ENCBS102ENC
DR   ENCODE; ENCBS103ENC
DR   ENCODE; ENCBS104ENC
DR   ENCODE; ENCBS105ENC
DR   ENCODE; ENCBS108ENC
DR   ENCODE; ENCBS110CZN
DR   ENCODE; ENCBS123ZGI
DR   ENCODE; ENCBS134PJO
DR   ENCODE; ENCBS135SOE
DR   ENCODE; ENCBS143XXF
DR   ENCODE; ENCBS148TCA
DR   ENCODE; ENCBS155VQC
DR   ENCODE; ENCBS158RRU
DR   ENCODE; ENCBS168ISE
DR   ENCODE; ENCBS174OTK
DR   ENCODE; ENCBS183ZAS
DR   ENCODE; ENCBS195LAY
DR   ENCODE; ENCBS200IWR
DR   ENCODE; ENCBS216AOQ
DR   ENCODE; ENCBS236AAA
DR   ENCODE; ENCBS237AAA
DR   ENCODE; ENCBS240AAA
DR   ENCODE; ENCBS241AAA
DR   ENCODE; ENCBS242AAA
DR   ENCODE; ENCBS243AAA
DR   ENCODE; ENCBS244AAA
DR   ENCODE; ENCBS245AAA
DR   ENCODE; ENCBS246AAA
DR   ENCODE; ENCBS247AAA
DR   ENCODE; ENCBS248AAA
DR   ENCODE; ENCBS249AAA
DR   ENCODE; ENCBS250AAA
DR   ENCODE; ENCBS251AAA
DR   ENCODE; ENCBS252AAA
DR   ENCODE; ENCBS253AAE
DR   ENCODE; ENCBS254AYH
DR   ENCODE; ENCBS267CRP
DR   ENCODE; ENCBS295JCF
DR   ENCODE; ENCBS295PFW
DR   ENCODE; ENCBS308QKF
DR   ENCODE; ENCBS312USZ
DR   ENCODE; ENCBS325VCY
DR   ENCODE; ENCBS328UKJ
DR   ENCODE; ENCBS331EJR
DR   ENCODE; ENCBS345ZJP
DR   ENCODE; ENCBS351GKC
DR   ENCODE; ENCBS402YIK
DR   ENCODE; ENCBS409BSE
DR   ENCODE; ENCBS448KAT
DR   ENCODE; ENCBS488MMM
DR   ENCODE; ENCBS496HCC
DR   ENCODE; ENCBS523HSQ
DR   ENCODE; ENCBS530DHL
DR   ENCODE; ENCBS536NWC
DR   ENCODE; ENCBS540TUZ
DR   ENCODE; ENCBS546VBU
DR   ENCODE; ENCBS547AXB
DR   ENCODE; ENCBS564FRY
DR   ENCODE; ENCBS567IJO
DR   ENCODE; ENCBS573TKZ
DR   ENCODE; ENCBS581MUA
DR   ENCODE; ENCBS584TFV
DR   ENCODE; ENCBS609QTY
DR   ENCODE; ENCBS614ENC
DR   ENCODE; ENCBS615ENC
DR   ENCODE; ENCBS616ENC
DR   ENCODE; ENCBS616MBU
DR   ENCODE; ENCBS637YEV
DR   ENCODE; ENCBS661RDG
DR   ENCODE; ENCBS670IYV
DR   ENCODE; ENCBS697UNO
DR   ENCODE; ENCBS705BBA
DR   ENCODE; ENCBS726ASX
DR   ENCODE; ENCBS737JTX
DR   ENCODE; ENCBS746EOD
DR   ENCODE; ENCBS747ZRJ
DR   ENCODE; ENCBS748WRO
DR   ENCODE; ENCBS758TZQ
DR   ENCODE; ENCBS764AUT
DR   ENCODE; ENCBS764NNP
DR   ENCODE; ENCBS773JGQ
DR   ENCODE; ENCBS778AGF
DR   ENCODE; ENCBS789UPK
DR   ENCODE; ENCBS842TPF
DR   ENCODE; ENCBS866ZXX
DR   ENCODE; ENCBS867ORK
DR   ENCODE; ENCBS868OVR
DR   ENCODE; ENCBS873NNF
DR   ENCODE; ENCBS902LKX
DR   ENCODE; ENCBS912WOF
DR   ENCODE; ENCBS947NBH
DR   ENCODE; ENCBS957OEW
DR   ENCODE; ENCBS959SHH
DR   ENCODE; ENCBS963BLD
DR   ENCODE; ENCBS967MVZ
DR   ENCODE; ENCBS968SNH
DR   ENCODE; ENCBS973EAA
DR   ENCODE; ENCBS974BZV
DR   GDSC; 905946
DR   GEO; GSM1723
DR   GEO; GSM2111
DR   GEO; GSM2137
DR   GEO; GSM2153
DR   GEO; GSM50183
DR   GEO; GSM50247
DR   GEO; GSM69199
DR   GEO; GSM73693
DR   GEO; GSM115111
DR   GEO; GSM155207
DR   GEO; GSM156025
DR   GEO; GSM185091
DR   GEO; GSM185092
DR   GEO; GSM211175
DR   GEO; GSM274640
DR   GEO; GSM276773
DR   GEO; GSM276774
DR   GEO; GSM276775
DR   GEO; GSM276776
DR   GEO; GSM276777
DR   GEO; GSM276778
DR   GEO; GSM276779
DR   GEO; GSM320172
DR   GEO; GSM344347
DR   GEO; GSM344397
DR   GEO; GSM350552
DR   GEO; GSM378140
DR   GEO; GSM388212
DR   GEO; GSM421869
DR   GEO; GSM459726
DR   GEO; GSM472936
DR   GEO; GSM481303
DR   GEO; GSM510510
DR   GEO; GSM533396
DR   GEO; GSM533413
DR   GEO; GSM590108
DR   GEO; GSM679692
DR   GEO; GSM679693
DR   GEO; GSM679694
DR   GEO; GSM736581
DR   GEO; GSM736588
DR   GEO; GSM739996
DR   GEO; GSM739997
DR   GEO; GSM739998
DR   GEO; GSM750771
DR   GEO; GSM750777
DR   GEO; GSM750778
DR   GEO; GSM750801
DR   GEO; GSM783949
DR   GEO; GSM799320
DR   GEO; GSM799383
DR   GEO; GSM816438
DR   GEO; GSM816627
DR   GEO; GSM816670
DR   GEO; GSM822295
DR   GEO; GSM822305
DR   GEO; GSM825711
DR   GEO; GSM827593
DR   GEO; GSM839033
DR   GEO; GSM847394
DR   GEO; GSM847490
DR   GEO; GSM844586
DR   GEO; GSM844587
DR   GEO; GSM887291
DR   GEO; GSM888366
DR   GEO; GSM923442
DR   GEO; GSM935445
DR   GEO; GSM935477
DR   GEO; GSM935563
DR   GEO; GSM945269
DR   GEO; GSM945274
DR   GEO; GSM945854
DR   GEO; GSM945857
DR   GEO; GSM967819
DR   GEO; GSM967823
DR   GEO; GSM970217
DR   GEO; GSM970218
DR   GEO; GSM987741
DR   GEO; GSM987742
DR   GEO; GSM987743
DR   GEO; GSM1008565
DR   GEO; GSM1008581
DR   GEO; GSM1008603
DR   GEO; GSM1008904
DR   GEO; GSM1010734
DR   GEO; GSM1010764
DR   GEO; GSM1010768
DR   GEO; GSM1010769
DR   GEO; GSM1010783
DR   GEO; GSM1010791
DR   GEO; GSM1010800
DR   GEO; GSM1010811
DR   GEO; GSM1010825
DR   GEO; GSM1010837
DR   GEO; GSM1010838
DR   GEO; GSM1010839
DR   GEO; GSM1010844
DR   GEO; GSM1010860
DR   GEO; GSM1010861
DR   GEO; GSM1010862
DR   GEO; GSM1010863
DR   GEO; GSM1010864
DR   GEO; GSM1010889
DR   GEO; GSM1010891
DR   GEO; GSM1010892
DR   GEO; GSM1022658
DR   GEO; GSM1022663
DR   GEO; GSM1029440
DR   GEO; GSM1029441
DR   GEO; GSM1029442
DR   GEO; GSM1029443
DR   GEO; GSM1029444
DR   GEO; GSM1029445
DR   GEO; GSM1029446
DR   GEO; GSM1029447
DR   GEO; GSM1029448
DR   GEO; GSM1029449
DR   GEO; GSM1040306
DR   GEO; GSM1040376
DR   GEO; GSM1053687
DR   GEO; GSM1068138
DR   GEO; GSM1068139
DR   GEO; GSM1153389
DR   GEO; GSM1172885
DR   GEO; GSM1178359
DR   GEO; GSM1178360
DR   GEO; GSM1181258
DR   GEO; GSM1181263
DR   GEO; GSM1214589
DR   GEO; GSM1238132
DR   GEO; GSM1374643
DR   GEO; GSM1374644
DR   GEO; GSM1374645
DR   GEO; GSM1401653
DR   GEO; GSM1670076
DR   GEO; GSM1833626
DR   GEO; GSM2046560
DR   GEO; GSM2046561
DR   GEO; GSM2046562
DR   GEO; GSM2046563
DR   GEO; GSM2046564
DR   GEO; GSM2046565
DR   GEO; GSM2046566
DR   GEO; GSM2046567
DR   GEO; GSM2046568
DR   GEO; GSM2046569
DR   GEO; GSM2046570
DR   GEO; GSM2046571
DR   GEO; GSM2046572
DR   GEO; GSM2046573
DR   GEO; GSM2046574
DR   GEO; GSM2046575
DR   GEO; GSM2046576
DR   GEO; GSM2046577
DR   GEO; GSM2046578
DR   GEO; GSM2046579
DR   GEO; GSM2046580
DR   GEO; GSM2046581
DR   GEO; GSM2046582
DR   GEO; GSM2046583
DR   GEO; GSM2046584
DR   GEO; GSM2046585
DR   GEO; GSM2046586
DR   GEO; GSM2046587
DR   GEO; GSM2046588
DR   GEO; GSM2046589
DR   GEO; GSM2046590
DR   GEO; GSM2046591
DR   GEO; GSM2046592
DR   GEO; GSM2046593
DR   GEO; GSM2046594
DR   GEO; GSM2046595
DR   GEO; GSM2046596
DR   GEO; GSM2046597
DR   GEO; GSM2046598
DR   GEO; GSM2046599
DR   GEO; GSM2046600
DR   GEO; GSM2046601
DR   GEO; GSM2046602
DR   GEO; GSM2046603
DR   GEO; GSM2046604
DR   GEO; GSM2046605
DR   GEO; GSM2046606
DR   GEO; GSM2046607
DR   GEO; GSM2095708
DR   GEO; GSM2095709
DR   GEO; GSM2124642
DR   GEO; GSM2136630
DR   GEO; GSM2136631
DR   GEO; GSM2136632
DR   GEO; GSM2136633
DR   GEO; GSM2136634
DR   GEO; GSM2136635
DR   GEO; GSM2176269
DR   GEO; GSM2176270
DR   IARC_TP53; 21079
DR   IBRC; C10082
DR   IBRC; C10682
DR   ICLC; HTL95021
DR   IGRhCellID; MCF7
DR   IPD-IMGT/HLA; 12401
DR   IZSLER; BS TCL 38
DR   JCRB; JCRB0134
DR   JCRB; NIHS0200
DR   KCB; KCB 200529YJ
DR   KCB; KCB 200831YJ
DR   KCLB; 30022
DR   LiGeA; CCLE_648
DR   LINCS_HMS; 50029
DR   LINCS_LDP; LCL-1460
DR   Lonza; 113
DR   MeSH; D061986
DR   MetaboLights; MTBLS177
DR   MetaboLights; MTBLS182
DR   MetaboLights; MTBLS241
DR   MetaboLights; MTBLS337
DR   MetaboLights; MTBLS430
DR   NCBI_Iran; C135
DR   NCI-DTP; MCF7
DR   PharmacoDB; MCF7_895_2019
DR   PRIDE; PXD000275
DR   PRIDE; PXD000281
DR   PRIDE; PXD000309
DR   PRIDE; PXD000442
DR   PRIDE; PXD000623
DR   PRIDE; PXD000691
DR   PRIDE; PXD000815
DR   PRIDE; PXD001274
DR   PRIDE; PXD001352
DR   PRIDE; PXD001812
DR   PRIDE; PXD001863
DR   PRIDE; PXD002104
DR   PRIDE; PXD002192
DR   PRIDE; PXD002395
DR   PRIDE; PXD002421
DR   PRIDE; PXD002998
DR   PRIDE; PXD003704
DR   PRIDE; PXD004051
DR   PRIDE; PXD004085
DR   PRIDE; PXD004357
DR   PRIDE; PXD004452
DR   PRIDE; PXD005032
DR   PRIDE; PXD005390
DR   PRIDE; PXD005940
DR   PRIDE; PXD005942
DR   RCB; RCB1904
DR   SKY/M-FISH/CGH; 2814
DR   TKG; TKG 0479
DR   TOKU-E; 2383
DR   TOKU-E; 3748
DR   Wikidata; Q1881253
RX   CelloPub=CLPUB00336;
RX   CelloPub=CLPUB00423;
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RX   DOI=10.4172/2157-7145.S2-005;
RX   PubMed=1000504;
RX   PubMed=1000505;
RX   PubMed=1000506;
RX   PubMed=1911442;
RX   PubMed=3335022;
RX   PubMed=3518877;
RX   PubMed=3702420;
RX   PubMed=4138511;
RX   PubMed=4357757;
RX   PubMed=6582512;
RX   PubMed=6935474;
RX   PubMed=7228867;
RX   PubMed=7498097;
RX   PubMed=7531416;
RX   PubMed=7842014;
RX   PubMed=8626706;
RX   PubMed=8824553;
RX   PubMed=9242427;
RX   PubMed=9671407;
RX   PubMed=10700174;
RX   PubMed=10862037;
RX   PubMed=11044355;
RX   PubMed=11078910;
RX   PubMed=11292682;
RX   PubMed=11789735;
RX   PubMed=12353263;
RX   PubMed=12661003;
RX   PubMed=12775708;
RX   PubMed=12800145;
RX   PubMed=15002416;
RX   PubMed=15677628;
RX   PubMed=15748285;
RX   PubMed=15767549;
RX   PubMed=15900046;
RX   PubMed=16142302;
RX   PubMed=16397213;
RX   PubMed=16541312;
RX   PubMed=17088437;
RX   PubMed=17157791;
RX   PubMed=17254797;
RX   PubMed=18386134;
RX   PubMed=18516279;
RX   PubMed=19372543;
RX   PubMed=19582160;
RX   PubMed=19593635;
RX   PubMed=19727395;
RX   PubMed=20070913;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=21247443;
RX   PubMed=21378333;
RX   PubMed=22068913;
RX   PubMed=22278370;
RX   PubMed=22336246;
RX   PubMed=22384151;
RX   PubMed=22414580;
RX   PubMed=22460905;
RX   PubMed=22585861;
RX   PubMed=22628656;
RX   PubMed=23234512;
RX   PubMed=23285151;
RX   PubMed=23325432;
RX   PubMed=23601657;
RX   PubMed=23671654;
RX   PubMed=23770244;
RX   PubMed=23856246;
RX   PubMed=23868472;
RX   PubMed=23933261;
RX   PubMed=24009699;
RX   PubMed=24094812;
RX   PubMed=24162158;
RX   PubMed=24176112;
RX   PubMed=24279929;
RX   PubMed=24618588;
RX   PubMed=24670534;
RX   PubMed=25321415;
RX   PubMed=25485619;
RX   PubMed=25807930;
RX   PubMed=25828948;
RX   PubMed=25960936;
RX   PubMed=25984343;
RX   PubMed=26026074;
RX   PubMed=26055192;
RX   PubMed=26116361;
RX   PubMed=26330541;
RX   PubMed=27331101;
RX   PubMed=27362937;
RX   PubMed=27377824;
RX   PubMed=27397505;
RX   PubMed=27456714;
RX   PubMed=27761513;
RX   PubMed=27807467;
RX   PubMed=28196595;
RX   PubMed=28287265;
RX   PubMed=28601559;
RX   PubMed=28889351;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
WW   https://en.wikipedia.org/wiki/MCF-7
WW   http://mcf7.com/
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=MCF-7
WW   https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
WW   https://physics.cancer.gov/docs/bioresource/breast/NCI-PBCF-HTB22_MCF7_SOP-508.pdf
WW   https://strap.nci.nih.gov/celline_detail.php?sample_id=1
WW   http://www.proteinatlas.org/learn/cellines
WW   http://141.61.102.20/mxdb/project/show/9191407937500
WW   http://www.genboree.org/java-bin/MCF7/index.jsp?isPublic=Yes
WW   http://www.pawefish.path.cam.ac.uk/BreastCellLineDescriptions/mcf7.htm
WW   http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=MCF7
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/MCF-7_Crawford_protocol.pdf
WW   http://lincs.hms.harvard.edu/resources/reagents/icbp43/
WW   http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-36.html
WW   http://archive.bcaction.org/index.php?page=newsletter-66i
WW   https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
WW   https://www.phe-culturecollections.org.uk/media/130237/mcf7-cell-line-profile.pdf
WW   http://tcpaportal.org/mclp/
WW   http://www.cellresource.cn/fdetail.aspx?id=13
WW   http://www.cellresource.cn/fdetail.aspx?id=328
WW   http://www.cellresource.cn/fdetail.aspx?id=642
WW   http://www.cellresource.cn/fdetail.aspx?id=822
CC   Group: Space-flown cell line (cellonaut).
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: ENCODE project common cell types; tier 2.
CC   Part of: JFCR39 cancer cell line panel.
CC   Part of: JFCR45 cancer cell line panel.
CC   Part of: GrayJW breast cancer cell line panel.
CC   Part of: ICBP43 breast cancer cell line panel.
CC   Part of: KuDOS 95 cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: NCI-60 cancer cell line panel.
CC   Registration: Chiron Master Culture Collection; CMCC 10377 (CMCC #10377).
CC   Doubling time: 1.8 days (PubMed=9671407); 80 hours (PubMed=25984343); 31.2 hours (PubMed=22628656); 25.4 hours (NCI-DTP); ~50 hours, with a range of 30-72 hours (DSMZ); ~38 hours (PBCF); 56.47 hours (https://www.synapse.org/#!Synapse:syn2347014).
CC   HLA typing: A*02:01:01; B*18,44; C*05; DPB1*02:01:02,04:01; DQB1*02:01,06:02; DRB1*03,15 (PubMed=15748285).
CC   HLA typing: A*02:01,02:01; B*18:01,44:02; C*05:01,05:01; DQA1*01:02,01:02; DQB1*06:02,06:02; DRB1*15:01,15:01 (PubMed=25960936).
CC   Microsatellite instability: Stable (MSS) (PubMed=12661003; PubMed=23671654; Sanger).
CC   Sequence variation: Homozygous for CDKN2A deletion (PubMed=19593635).
CC   Sequence variation: Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (PubMed=17088437; PubMed=19593635; PubMed=28889351).
CC   Sequence variation: Has no TP53 mutation (PubMed=15900046).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep antibody staining analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep phosphoproteome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Fluorescence phenotype profiling.
CC   Omics: Glycoproteome analysis by proteomics.
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: H3K27me3 ChIP-seq epigenome analysis.
CC   Omics: H3K36me3 ChIP-seq epigenome analysis.
CC   Omics: H3K4me3 ChIP-seq epigenome analysis.
CC   Omics: H3K9me3 ChIP-seq epigenome analysis.
CC   Omics: lncRNA expression profiling.
CC   Omics: Metabolome analysis.
CC   Omics: miRNA expression profiling.
CC   Omics: Myristoylated proteins analysis by proteomics.
CC   Omics: N-glycan profiling.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Omics: Virome analysis using proteomics.
CC   Genome ancestry: African=0.74%; Native American=0%; East Asian, North=4.2%; East Asian, South=0%; South Asian=0%; European, North=56.91%; European, South=38.15% (PubMed=30894373).
CC   Anecdotal: This is the first hormone-responsive breast cancer cell line to have been established.
CC   Anecdotal: Helen Mallon (sister Catherine Frances), the patient from which this cell line is derived was a nun (Sister Catherine Frances) at the Immaculate Heart of Mary Convent in Monroe, Michigan.
CC   Anecdotal: Have been flown in space on Foton-12 to study cytoskeleton architecture in microgravity (PubMed=11292682; PubMed=15002416).
CC   Misspelling: MFC-7; Occasionally.
CC   Discontinued: ATCC; CRL-12584; probable.
CC   Discontinued: JCRB; NIHS0200; true.
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; DOI=10.4172/2157-7145.S2-005; PubMed=11416159; PubMed=17254797; PubMed=19372543; PubMed=25321415; PubMed=25877200; PubMed=27456714; PubMed=28889351; RCB; TKG
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D12S391: 18,20
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 14
ST   D19S433: 13,14
ST   D1S1656: 15.3
ST   D21S11: 30
ST   D2S1338: 21,23
ST   D3S1358: 16
ST   D5S818: 11,12 (AddexBio; ATCC; CCRID; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; DOI=10.4172/2157-7145.S2-005; PubMed=11416159; PubMed=17254797; PubMed=19372543; PubMed=25321415; PubMed=25877200; PubMed=27456714; PubMed=28889351; RCB; TKG)
ST   D5S818: 12 (CLS)
ST   D6S1043: 12,18
ST   D7S820: 8,9
ST   D8S1179: 10,14
ST   FGA: 23,24,25 (CCRID)
ST   FGA: 23,25 (CLS; PubMed=17254797; PubMed=19372543; PubMed=25877200)
ST   Penta D: 12
ST   Penta E: 7,12
ST   TH01: 6
ST   TPOX: 9,12
ST   vWA: 14,15
DI   NCIt; C4194; Invasive ductal carcinoma, not otherwise specified
OX   NCBI_TaxID=9606; ! Homo sapiens
OI   CVCL_N481 ! Hs 631.T
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-07-20; Version: 35
//
RX   CelloPub=CLPUB00336;
RA   Crane A., Brennan M., Naebers R.;
RT   "Catherine Frances Mallon's 'immortal cells'.";
RL   IHM Arch. Notes 4:2.1-2.1(2013).
//
RX   CelloPub=CLPUB00423;
RA   Morrison B.J.;
RT   "Breast cancer stem cells: tumourspheres and implications for therapy.";
RL   Thesis PhD (2010), Griffith University, Australia.
//
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RA   Leibovitz A.;
RT   "Cell lines from human breast.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York (1994).
//
RX   DOI=10.4172/2157-7145.S2-005;
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RA   Furtado M.R.;
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RT   to the growing problem.";
RL   J. Forensic Res. 2 Suppl. 2:5-5(2011).
//
RX   PubMed=1000504;
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RT   human breast cancer in long-term tissue culture.";
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//
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RT   "The effects of glucocorticoids and progesterone on hormone-responsive
RT   human breast cancer in long-term tissue culture.";
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//
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RT   "The effects of androgens and antiandrogens on hormone-responsive
RT   human breast cancer in long-term tissue culture.";
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//
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RT   "Metabolism of the oral contraceptive steroids ethynylestradiol and
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//
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//
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//
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RA   Heuson J.C.;
RT   "Induction of progesterone receptor in an estrogen, progesterone
RT   receptor-negative breast cancer cell line.";
RL   J. Steroid Biochem. 24:365-368(1986).
//
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RT   cell line, MCF-7.";
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//
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RT   "A human cell line from a pleural effusion derived from a breast
RT   carcinoma.";
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//
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//
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RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
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RT   "Isolation and characterization of a tamoxifen-resistant cell line
RT   derived from MCF-7 human breast cancer cells.";
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//
RX   PubMed=7498097; DOI=10.1289/ehp.95103844;
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//
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RT   "Effects of tamoxifen on potential doubling time of human breast
RT   cancer cell line determined by image cytometry of double fluorescent
RT   BrdU and DNA labeling.";
RL   Anticancer Res. 14:2025-2032(1994).
//
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RT   "Identification of cryptic sites of DNA sequence amplification in
RT   human breast cancer by chromosome microdissection.";
RL   Nat. Genet. 8:155-161(1994).
//
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RT   "Insulin-like growth factor expression in human cancer cell lines.";
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//
RX   PubMed=8824553; DOI=10.1002/(SICI)1097-0215(19960917)67:6<816::AID-IJC10>3.0.CO;2-#;
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RT   "Effect of Matrigel on the tumorigenicity of human breast and ovarian
RT   carcinoma cell lines.";
RL   Int. J. Cancer 67:816-820(1996).
//
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RA   Levenson A.S., Jordan V.C.;
RT   "MCF-7: the first hormone-responsive breast cancer cell line.";
RL   Cancer Res. 57:3071-3078(1997).
//
RX   PubMed=9671407; DOI=10.1038/sj.onc.1201814;
RA   Sweeney K.J., Swarbrick A., Sutherland R.L., Musgrove E.A.;
RT   "Lack of relationship between CDK activity and G1 cyclin expression in
RT   breast cancer cells.";
RL   Oncogene 16:2865-2878(1998).
//
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RT   lines.";
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//
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RA   Isola J., Larsson C.;
RT   "Chromosomal alterations in 15 breast cancer cell lines by comparative
RT   genomic hybridization and spectral karyotyping.";
RL   Genes Chromosomes Cancer 28:308-317(2000).
//
RX   PubMed=11044355; DOI=10.1054/bjoc.2000.1458;
RA   Davidson J.M., Gorringe K.L., Chin S.-F., Orsetti B., Besret C.,
RA   Courtay-Cahen C., Roberts I., Theillet C., Caldas C., Edwards P.A.W.;
RT   "Molecular cytogenetic analysis of breast cancer cell lines.";
RL   Br. J. Cancer 83:1309-1317(2000).
//
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RA   Lilling G., Hacohen H., Nordenberg J., Livnat T., Rotter V., Sidi Y.;
RT   "Differential sensitivity of MCF-7 and LCC2 cells, to multiple growth
RT   inhibitory agents: possible relation to high bcl-2/bax ratio?";
RL   Cancer Lett. 161:27-34(2000).
//
RX   PubMed=11292682; DOI=10.1096/fj.00-0527fje;
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RA   Karniguian A., Gasset G., Irinopoulou T., Calvo F., Rigaut J.P.,
RA   Schoevaert D.;
RT   "The effect of weightlessness on cytoskeleton architecture and
RT   proliferation of human breast cancer cell line MCF-7.";
RL   FASEB J. 15:1104-1106(2001).
//
RX   PubMed=11789735; DOI=10.1309/4NCM-QJ9W-QM0J-6QJE;
RA   Rhodes A., Jasani B., Couturier J., McKinley M.J., Morgan J.M.,
RA   Dodson A.R., Navabi H., Miller K.D., Balaton A.J.;
RT   "A formalin-fixed, paraffin-processed cell line standard for quality
RT   control of immunohistochemical assay of HER-2/neu expression in breast
RT   cancer.";
RL   Am. J. Clin. Pathol. 117:81-89(2002).
//
RX   PubMed=12353263; DOI=10.1002/gcc.10107;
RA   Popovici C., Basset C., Bertucci F., Orsetti B., Adelaide J.,
RA   Mozziconacci M.-J., Conte N., Murati A., Ginestier C.,
RA   Charafe-Jauffret E., Ethier S.P., Lafage-Pochitaloff M., Theillet C.,
RA   Birnbaum D., Chaffanet M.;
RT   "Reciprocal translocations in breast tumor cell lines: cloning of a
RT   t(3;20) that targets the FHIT gene.";
RL   Genes Chromosomes Cancer 35:204-218(2002).
//
RX   PubMed=12661003; DOI=10.1002/gcc.10196;
RA   Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U.,
RA   Santibanez-Koref M.-F., Schlag P.M., Scherneck S.;
RT   "Identification of microsatellite instability and mismatch repair gene
RT   mutations in breast cancer cell lines.";
RL   Genes Chromosomes Cancer 37:29-35(2003).
//
RX   PubMed=12775708; DOI=10.1074/jbc.M305226200;
RA   Martin L.-A., Farmer I., Johnston S.R.D., Ali S., Marshall C.,
RA   Dowsett M.;
RT   "Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal
RT   transduction pathways operate during the adaptation of MCF-7 cells to
RT   long term estrogen deprivation.";
RL   J. Biol. Chem. 278:30458-30468(2003).
//
RX   PubMed=12800145; DOI=10.1002/gcc.10218;
RA   Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B.,
RA   Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A.,
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RA   Edwards P.A.W., Chaffanet M.;
RT   "A recurrent chromosome translocation breakpoint in breast and
RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
//
RX   PubMed=15002416; DOI=10.1016/S0273-1177(03)90400-5;
RA   Vassy J., Portet S., Beil M., Millot G., Fauvel-Lafeve F., Gasset G.,
RA   Schoevaert D.;
RT   "Weightlessness acts on human breast cancer cell line MCF-7.";
RL   Adv. Space Res. 32:1595-1603(2003).
//
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
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RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
//
RX   PubMed=15748285; DOI=10.1186/1479-5876-3-11;
RA   Adams S., Robbins F.-M., Chen D., Wagage D., Holbeck S.L.,
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RT   "HLA class I and II genotype of the NCI-60 cell lines.";
RL   J. Transl. Med. 3:11-11(2005).
//
RX   PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234;
RA   Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y.,
RA   Yamori T.;
RT   "Chemosensitivity profile of cancer cell lines and identification of
RT   genes determining chemosensitivity by an integrated bioinformatical
RT   approach using cDNA arrays.";
RL   Mol. Cancer Ther. 4:399-412(2005).
//
RX   PubMed=15900046; DOI=10.1093/jnci/dji133;
RA   Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y.,
RA   Yamazaki K., Hamada J., Tada M., Moriuchi T., Ishikawa Y., Kato Y.,
RA   Tomoda H., Yamori T., Tsuruo T.;
RT   "p53-defective tumors with a functional apoptosome-mediated pathway: a
RT   new therapeutic target.";
RL   J. Natl. Cancer Inst. 97:765-777(2005).
//
RX   PubMed=16142302; DOI=10.3892/ijo.27.4.881;
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RT   low-density microarray.";
RL   Int. J. Oncol. 27:881-892(2005).
//
RX   PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853;
RA   Elstrodt F., Hollestelle A., Nagel J.H.A., Gorin M., Wasielewski M.,
RA   van den Ouweland A., Merajver S.D., Ethier S.P., Schutte M.;
RT   "BRCA1 mutation analysis of 41 human breast cancer cell lines reveals
RT   three new deleterious mutants.";
RL   Cancer Res. 66:41-45(2006).
//
RX   PubMed=16541312; DOI=10.1007/s10549-006-9186-z;
RA   Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.;
RT   "Thirteen new p53 gene mutants identified among 41 human breast cancer
RT   cell lines.";
RL   Breast Cancer Res. Treat. 99:97-101(2006).
//
RX   PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433;
RA   Ikediobi O.N., Davies H., Bignell G.R., Edkins S., Stevens C.,
RA   O'Meara S., Santarius T., Avis T., Barthorpe S., Brackenbury L.,
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RT   "Mutation analysis of 24 known cancer genes in the NCI-60 cell line
RT   set.";
RL   Mol. Cancer Ther. 5:2606-2612(2006).
//
RX   PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008;
RA   Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T.,
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RT   functionally distinct cancer subtypes.";
RL   Cancer Cell 10:515-527(2006).
//
RX   PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001;
RA   Azari S., Ahmadi N., Tehrani M.J., Shokri F.;
RT   "Profiling and authentication of human cell lines using short tandem
RT   repeat (STR) loci: report from the National Cell Bank of Iran.";
RL   Biologicals 35:195-202(2007).
//
RX   PubMed=18386134; DOI=10.1007/s10585-008-9169-z;
RA   Hughes L., Malone C., Chumsri S., Burger A.M., McDonnell S.;
RT   "Characterisation of breast cancer cell lines and establishment of a
RT   novel isogenic subclone to study migration, invasion and
RT   tumourigenicity.";
RL   Clin. Exp. Metastasis 25:549-557(2008).
//
RX   PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004;
RA   Kenny P.A., Lee G.Y., Myers C.A., Neve R.M., Semeiks J.R.,
RA   Spellman P.T., Lorenz K., Lee E.H., Barcellos-Hoff M.H.,
RA   Petersen O.W., Gray J.W., Bissell M.J.;
RT   "The morphologies of breast cancer cell lines in three-dimensional
RT   assays correlate with their profiles of gene expression.";
RL   Mol. Oncol. 1:84-96(2007).
//
RX   PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921;
RA   Lorenzi P.L., Reinhold W.C., Varma S., Hutchinson A.A., Pommier Y.,
RA   Chanock S.J., Weinstein J.N.;
RT   "DNA fingerprinting of the NCI-60 cell line panel.";
RL   Mol. Cancer Ther. 8:713-724(2009).
//
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RA   Kao J., Salari K., Bocanegra M., Choi Y.-L., Girard L., Gandhi J.,
RA   Kwei K.A., Hernandez-Boussard T., Wang P., Gazdar A.F., Minna J.D.,
RA   Pollack J.R.;
RT   "Molecular profiling of breast cancer cell lines defines relevant
RT   tumor models and provides a resource for cancer gene discovery.";
RL   PLoS ONE 4:E6146-E6146(2009).
//
RX   PubMed=19593635; DOI=10.1007/s10549-009-0460-8;
RA   Hollestelle A., Nagel J.H.A., Smid M., Lam S., Elstrodt F.,
RA   Wasielewski M., Ng S.S., French P.J., Peeters J.K., Rozendaal M.J.,
RA   Riaz M., Koopman D.G., ten Hagen T.L.M., de Leeuw B.H.C.G.M.,
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RA   Dinjens W.N.M., Ethier S.P., Clevers H., Jochemsen A.G., den Bakker M.A.,
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RT   "Distinct gene mutation profiles among luminal-type and basal-type
RT   breast cancer cell lines.";
RL   Breast Cancer Res. Treat. 121:53-64(2010).
//
RX   PubMed=19727395; DOI=10.1371/journal.pone.0006888;
RA   Wadlow R.C., Wittner B.S., Finley S.A., Bergquist H., Upadhyay R.,
RA   Finn S., Loda M., Mahmood U., Ramaswamy S.;
RT   "Systems-level modeling of cancer-fibroblast interaction.";
RL   PLoS ONE 4:E6888-E6888(2009).
//
RX   PubMed=20070913; DOI=10.1186/1471-2407-10-15;
RA   Tsuji K., Kawauchi S., Saito S., Furuya T., Ikemoto K., Nakao M.,
RA   Yamamoto S., Oka M., Hirano T., Sasaki K.;
RT   "Breast cancer cell lines carry cell line-specific genomic alterations
RT   that are distinct from aberrations in breast cancer tissues:
RT   comparison of the CGH profiles between cancer cell lines and primary
RT   cancer tissues.";
RL   BMC Cancer 10:15-15(2010).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
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RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
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RA   Haber D.A.;
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