Cell line name | SK-BR-3 | ||||||||||||||||||||||||||||||||||||
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Synonyms | SK-Br-3; Sk-Br-3; SK BR 03; SKBR-3; SKBr-3; SK-BR3; SKBr3; SkBr3; SKBR3 | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_0033 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: SK-BR-3 (RRID:CVCL_0033) | ||||||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: GrayJW breast cancer cell line panel. Part of: ICBP43 breast cancer cell line panel. Part of: KuDOS 95 cell line panel. Part of: MD Anderson Cell Lines Project. From: Memorial Sloan Kettering Cancer Center; New York; USA. Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 808. Doubling time: ~30 hours (CLS); ~2-3 days (DSMZ); 56.19 hours (https://www.synapse.org/#!Synapse:syn2347014). Microsatellite instability: Stable (MSS) (PubMed=23671654). Omics: Array-based CGH. Omics: CNV analysis. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep proteome analysis. Omics: Deep RNAseq analysis. Omics: Exosome proteome analysis. Omics: Genome sequenced. Omics: Glycoproteome analysis by proteomics. Omics: miRNA expression profiling. Omics: N-glycan profiling. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis. Misspelling: SKBR3B; In PubMed=26378940. Discontinued: TKG; TKG 0592; true. | ||||||||||||||||||||||||||||||||||||
Sequence variations | Homozygous for CDH1 deletion (PubMed=19593635).Homozygous for TP53 p.Arg175His (c.524G>A) (ClinVar=VCV000012374) (PubMed=16541312; PubMed=28889351; ATCC; CCLE). | ||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=25960936
Source: IPD-IMGT/HLA; 12368
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Genome ancestry | Source: PubMed=30894373
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Disease | Breast adenocarcinoma (NCIt: C5214) Derived from metastatic site: Pleural effusion. | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Originate from same individual | CVCL_1074 ! AU565 | ||||||||||||||||||||||||||||||||||||
Sex of cell | Female | ||||||||||||||||||||||||||||||||||||
Age at sampling | 43Y | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio; ATCC; CLS; DSMZ; KCLB; MSKCC; PubMed=25877200; PubMed=28889351; RCB Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/SKBR3 http://www.pawefish.path.cam.ac.uk/BreastCellLineDescriptions/sk-br-3.htm http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=SK-BR-3 http://www.proteinatlas.org/learn/cellines http://lincs.hms.harvard.edu/resources/reagents/icbp43/ http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-57.html https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-breast-cell-line-sk-br-3 https://www.synapse.org/#!Synapse:syn2346643/wiki/62255 http://tcpaportal.org/mclp/ http://www.cellresource.cn/fdetail.aspx?id=85 http://www.cellresource.cn/fdetail.aspx?id=618 http://www.cellresource.cn/fdetail.aspx?id=1964 | ||||||||||||||||||||||||||||||||||||
Publications | DOI=10.1007/978-1-4757-1647-4_5 PubMed=1013510; DOI=10.1007/978-3-642-81043-5_5 PubMed=327080; DOI=10.1093/jnci/59.1.221 PubMed=833871; DOI=10.1093/jnci/58.2.209 PubMed=6935474; DOI=10.1093/jnci/66.2.239 PubMed=7017212; DOI=10.1093/jnci/66.6.1003 PubMed=6401685; DOI=10.1007/BF02617989 PubMed=6500159; DOI=10.1159/000163283 PubMed=6582512; DOI=10.1073/pnas.81.2.568 PubMed=3518877; DOI=10.3109/07357908609038260 DOI=10.1016/B978-0-12-333530-2.50009-5 PubMed=9671407; DOI=10.1038/sj.onc.1201814 PubMed=10862037; DOI=10.1002/1098-2264(200007)28:3<308::AID-GCC9>3.0.CO;2-B PubMed=11044355; DOI=10.1054/bjoc.2000.1458 PubMed=12800145; DOI=10.1002/gcc.10218 PubMed=15677628; DOI=10.1093/carcin/bgi032 PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853 PubMed=16541312; DOI=10.1007/s10549-006-9186-z PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008 PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004 PubMed=19582160; DOI=10.1371/journal.pone.0006146 PubMed=19727395; DOI=10.1371/journal.pone.0006888 CLPUB00423 PubMed=19593635; DOI=10.1007/s10549-009-0460-8 PubMed=20070913; DOI=10.1186/1471-2407-10-15 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=21247443; DOI=10.1186/gb-2011-12-1-r6 PubMed=21378333 PubMed=22460905; DOI=10.1038/nature11003 PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224 PubMed=23151021; DOI=10.1186/1471-2164-13-619 PubMed=23601657; DOI=10.1186/bcr3415 PubMed=23671654; DOI=10.1371/journal.pone.0063056 PubMed=24009699; DOI=10.1371/journal.pone.0072704 PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020 PubMed=24162158; DOI=10.1007/s10549-013-2743-3 PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110 PubMed=25960936; DOI=10.4161/21624011.2014.954893 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=26055192; DOI=10.1021/acs.jproteome.5b00375 PubMed=26378940; DOI=10.1021/acs.analchem.5b02586 PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 PubMed=28287265; DOI=10.1021/acs.jproteome.6b00470 PubMed=28889351; DOI=10.1007/s10549-017-4496-x PubMed=29954844; DOI=10.1101/gr.231100.117 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections | AddexBio; C0006007/65
ATCC; HTB-30 BCRJ; 0226 CCTCC; GDC0286 CLS; 300333/p3803_SK-BR-3 DSMZ; ACC-736 IBRC; C10147 ICLC; HTL03005 IZSLER; BS TCL 156 KCB; KCB 200723YJ KCLB; 30030 NCBI_Iran; C207 RCB; RCB2132 - Discontinued TKG; TKG 0592 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl4310
CLDB; cl7143 CCLE; SKBR3_BREAST CCRID; 3111C0001CCC000085 CCRID; 3131C0001000700049 CCRID; 3142C0001000000313 Cell_Model_Passport; SIDM00897 DepMap; ACH-000017 IPD-IMGT/HLA; 12368 LINCS_HMS; 50057 LINCS_LDP; LCL-1475 Lonza; 70 TOKU-E; 3129 | ||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0002419
CLO; CLO_0009034 CLO; CLO_0037295 EFO; EFO_0001236 MCCL; MCC:0000424 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN01821597
BioSample; SAMN03471462 BioSample; SAMN10987910 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308062
ChEMBL-Targets; CHEMBL613834 PharmacoDB; SKBR3_1383_2019 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770 ArrayExpress; E-TABM-157 ArrayExpress; E-TABM-244 GEO; GSM69195 GEO; GSM73742 GEO; GSM115115 GEO; GSM149978 GEO; GSM149986 GEO; GSM149994 GEO; GSM152556 GEO; GSM152557 GEO; GSM152558 GEO; GSM152559 GEO; GSM154096 GEO; GSM154097 GEO; GSM154098 GEO; GSM154099 GEO; GSM154100 GEO; GSM154101 GEO; GSM154102 GEO; GSM154104 GEO; GSM154107 GEO; GSM155215 GEO; GSM170624 GEO; GSM170625 GEO; GSM170626 GEO; GSM170627 GEO; GSM170630 GEO; GSM170631 GEO; GSM170633 GEO; GSM170634 GEO; GSM183440 GEO; GSM183441 GEO; GSM186457 GEO; GSM186458 GEO; GSM217596 GEO; GSM274644 GEO; GSM274663 GEO; GSM344357 GEO; GSM344407 GEO; GSM350501 GEO; GSM378146 GEO; GSM421883 GEO; GSM481334 GEO; GSM590106 GEO; GSM595617 GEO; GSM783927 GEO; GSM827582 GEO; GSM845399 GEO; GSM847432 GEO; GSM847499 GEO; GSM844686 GEO; GSM844687 GEO; GSM887575 GEO; GSM888658 GEO; GSM1008913 GEO; GSM1038850 GEO; GSM1038851 GEO; GSM1038852 GEO; GSM1038853 GEO; GSM1038854 GEO; GSM1053720 GEO; GSM1172989 GEO; GSM1172895 GEO; GSM1214572 GEO; GSM1238124 GEO; GSM1264069 GEO; GSM1264074 GEO; GSM1264111 GEO; GSM1264116 GEO; GSM1374872 GEO; GSM1374873 GEO; GSM1374874 GEO; GSM1401659 GEO; GSM1661988 GEO; GSM1833627 | ||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q7390592 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 687499
Cosmic; 755294 Cosmic; 759896 Cosmic; 871159 Cosmic; 894090 Cosmic; 897742 Cosmic; 904385 Cosmic; 921974 Cosmic; 923062 Cosmic; 934531 Cosmic; 944297 Cosmic; 979713 Cosmic; 991329 Cosmic; 997935 Cosmic; 1000127 Cosmic; 1010922 Cosmic; 1018478 Cosmic; 1044209 Cosmic; 1046958 Cosmic; 1129655 Cosmic; 1136357 Cosmic; 1176645 Cosmic; 1287914 Cosmic; 1289405 Cosmic; 1308997 Cosmic; 1434957 Cosmic; 1524342 Cosmic; 1571789 Cosmic; 1609462 Cosmic; 2036669 Cosmic; 2165013 Cosmic; 2301535 Cosmic; 2318379 Cosmic; 2361351 IARC_TP53; 580 LiGeA; CCLE_391 Progenetix; CVCL_0033 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD000691
PRIDE; PXD002053 PRIDE; PXD002057 PRIDE; PXD002281 PRIDE; PXD002486 PRIDE; PXD005390 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 29-Oct-2020 | ||||||||||||||||||||||||||||||||||||
Version number | 32 |