Cell line name | A-431 | ||||||||||||||||||||||||||||||||||||
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Synonyms | A431; A431/P | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_0037 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: A-431 (RRID:CVCL_0037) | ||||||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Doubling time: ~80-100 hours (DSMZ). Microsatellite instability: Stable (MSS) (Sanger). Omics: Cell surface proteome. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep phosphoproteome analysis. Omics: Deep proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. | ||||||||||||||||||||||||||||||||||||
Sequence variations | EGFR-PPARGC1A gene fusion (PubMed=23637631).TP53 p.Arg273His (c.818G>A) (PubMed=1394225). | ||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=25960936
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Genome ancestry | Source: PubMed=30894373
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Disease | Vulvar squamous cell carcinoma (NCIt: C4052) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Sex of cell | Female | ||||||||||||||||||||||||||||||||||||
Age at sampling | 85Y | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; DSMZ; JCRB; KCLB; PubMed=11416159; PubMed=25877200; RCB; TKG Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/A431_cells http://www.cells-talk.com/index.php/page/copelibrary?key=A431 http://www.proteinatlas.org/learn/cellines http://micro.magnet.fsu.edu/primer/techniques/fluorescence/gallery/cells/a431/a431cells.html http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/a/cell-lines-detail-78.html http://www.cellresource.cn/fdetail.aspx?id=92 http://www.cellresource.cn/fdetail.aspx?id=647 http://www.cellresource.cn/fdetail.aspx?id=871 http://www.cellresource.cn/fdetail.aspx?id=2093 | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=4357758; DOI=10.1093/jnci/51.5.1417 PubMed=212188 PubMed=6254071; DOI=10.1073/pnas.77.9.5258 PubMed=22282976; DOI=10.1093/carcin/1.1.21 PubMed=6092175; DOI=10.1016/0303-7207(84)90053-4 PubMed=6500159; DOI=10.1159/000163283 PubMed=2990217 PubMed=2758419 PubMed=2228902; DOI=10.1007/BF02624609 PubMed=1394225 PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D PubMed=9887230; DOI=10.1006/gyno.1998.5194 PubMed=17178626; DOI=10.1080/09553000600969812 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=22108792; DOI=10.1038/msb.2011.84 PubMed=23637631; DOI=10.1371/journal.pgen.1003464 PubMed=24804581; DOI=10.1021/cb500116c PubMed=25960936; DOI=10.4161/21624011.2014.954893 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=25894527; DOI=10.1371/journal.pone.0121314 PubMed=26989177; DOI=10.1242/dev.133728 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=28176443; DOI=10.1002/pmic.201600254 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections | AddexBio; C0012001/22
ATCC; CRL-1555 ATCC; CRL-7907 - Discontinued BCRC; 60161 BCRJ; 0032 CCTCC; GDC0084 CLS; 300112/p753_A-431 DSMZ; ACC-91 ECACC; 85090402 IZSLER; BS TCL 161 JCRB; IFO50411 JCRB; JCRB0004 JCRB; JCRB9009 KCB; KCB 200651YJ KCLB; 21555 KCLB; 80005 NCBI_Iran; C204 RCB; RCB0202 RCB; RCB1872 TKG; TKG 0182 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl155
CLDB; cl156 CLDB; cl157 CLDB; cl159 CLDB; cl160 CLDB; cl161 CCLE; A431_SKIN CCRID; 3111C0001CCC000092 CCRID; 3131C0001000700079 CCRID; 3131C0001000700188 CCRID; 3142C0001000000103 Cell_Model_Passport; SIDM00995 Cosmic-CLP; 910925 DepMap; ACH-001328 GDSC; 910925 LINCS_LDP; LCL-1404 Lonza; 814 TOKU-E; 476 | ||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0000017
CLO; CLO_0001591 CLO; CLO_0001592 CLO; CLO_0050011 CLO; CLO_0050012 EFO; EFO_0006268 MCCL; MCC:0000025 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN01821614
BioSample; SAMN01821671 BioSample; SAMN01821724 BioSample; SAMN03472220 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307523
ChEMBL-Targets; CHEMBL614069 ChEMBL-Targets; CHEMBL1075390 PharmacoDB; A431_46_2019 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610 GEO; GSM183432 GEO; GSM183433 GEO; GSM827302 GEO; GSM1374384 GEO; GSM1669586 GEO; GSM2112551 GEO; GSM2112555 | ||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q4649310 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 688038
Cosmic; 735609 Cosmic; 755305 Cosmic; 876559 Cosmic; 897743 Cosmic; 910564 Cosmic; 910925 Cosmic; 974317 Cosmic; 1071898 Cosmic; 1176624 Cosmic; 1351516 Cosmic; 1477434 Cosmic; 1945879 Cosmic; 1995334 Cosmic; 2131571 Cosmic; 2301592 Cosmic; 2646654 IARC_TP53; 21167 IARC_TP53; 23618 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD000065
PRIDE; PXD000589 PRIDE; PXD000681 PRIDE; PXD001582 PRIDE; PXD003937 PRIDE; PXD006291 PRIDE; PXD005301 PRIDE; PXD007206 PRIDE; PXD008996 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry updated | 06-Sep-2019 | ||||||||||||||||||||||||||||||||||||
Version number | 32 |