ID   HUES 9
AC   CVCL_0057
SY   HUES-9; HUES9; HuES9; Hues9; HVRDe009-A
DR   EFO; EFO_0007094
DR   ENCODE; ENCBS579EEW
DR   GEO; GSM608014
DR   GEO; GSM608031
DR   GEO; GSM621718
DR   GEO; GSM637762
DR   hPSCreg; HVRDe009-A
DR   ISCR; 110
DR   NIHhESC; NIHhESC-10-0022
DR   SKIP; SKIP001492
DR   SKIP; SKIP001913
DR   Wikidata; Q54896821
RX   PubMed=14999088;
RX   PubMed=17572666;
RX   PubMed=19200798;
RX   PubMed=21295703;
RX   PubMed=21406692;
RX   PubMed=21637780;
RX   PubMed=29861859;
RX   PubMed=33360445;
CC   From: Harvard University; Boston; USA.
CC   Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0022.
CC   Registration: Swiss research registry; BAG-hES-IMP-0039.
CC   Registration: UK Stem Cell Bank (UKSCB); R-05-037, Steering comm. appl. SCSC04-25(9).
CC   Doubling time: 24 hours (PubMed=14999088).
CC   Omics: Deep phosphoproteome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
ST   Source(s): PubMed=19200798; PubMed=21637780; PubMed=33360445
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11,11.3 (PubMed=33360445)
ST   D13S317: 11,12 (PubMed=19200798; PubMed=21637780)
ST   D16S539: 12,13
ST   D18S51: 12,13
ST   D21S11: 29,30
ST   D3S1358: 17,18
ST   D5S818: 12
ST   D7S820: 8,12
ST   D8S1179: 9,12
ST   FGA: 19,21
ST   Penta D: 9,13
ST   Penta E: 10,12
ST   TH01: 8,9
ST   TPOX: 8,9
ST   vWA: 17,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 23
//
RX   PubMed=14999088; DOI=10.1056/NEJMsr040330;
RA   Cowan C.A., Klimanskaya I.V., McMahon J., Atienza J., Witmyer J.,
RA   Zucker J.P., Wang S.-P., Morton C.C., McMahon A.P., Powers D.,
RA   Melton D.A.;
RT   "Derivation of embryonic stem-cell lines from human blastocysts.";
RL   N. Engl. J. Med. 350:1353-1356(2004).
//
RX   PubMed=17572666; DOI=10.1038/nbt1318;
RA   Adewumi O., Aflatoonian B., Ahrlund-Richter L., Amit M., Andrews P.W.,
RA   Beighton G., Bello P.A., Benvenisty N., Berry L.S., Bevan S., Blum B.,
RA   Brooking J., Chen K.G., Choo A.B.-H., Churchill G.A., Corbel M.,
RA   Damjanov I., Draper J.S., Dvorak P., Emanuelsson K., Fleck R.A.,
RA   Ford A., Gertow K., Gertsenstein M., Gokhale P.J., Hamilton R.S.,
RA   Hampl A., Healy L.E., Hovatta O., Hyllner J., Imreh M.P.,
RA   Itskovitz-Eldor J., Jackson J., Johnson J.L., Jones M., Kee K.,
RA   King B.L., Knowles B.B., Lako M., Lebrin F., Mallon B.S., Manning D.,
RA   Mayshar Y., McKay R.D.G., Michalska A.E., Mikkola M., Mileikovsky M.,
RA   Minger S.L., Moore H.D., Mummery C.L., Nagy A., Nakatsuji N.,
RA   O'Brien C.M., Oh S.K.-W., Olsson C., Otonkoski T., Park K.-Y.,
RA   Passier R., Patel H., Patel M.J., Pedersen R., Pera M.F.,
RA   Piekarczyk M.S., Reijo Pera R.A., Reubinoff B.E., Robins A.J.,
RA   Rossant J., Rugg-Gunn P., Schulz T.C., Semb H., Sherrer E.S., Siemen H.,
RA   Stacey G.N., Stojkovic M., Suemori H., Szatkiewicz J., Turetsky T.T.,
RA   Tuuri T., van den Brink S., Vintersten K., Vuoristo S.,
RA   Ward-van Oostwaard D., Weaver T.A., Young L.A., Zhang W.-D.;
RT   "Characterization of human embryonic stem cell lines by the
RT   International Stem Cell Initiative.";
RL   Nat. Biotechnol. 25:803-816(2007).
//
RX   PubMed=19200798; DOI=10.1016/j.stem.2008.12.001;
RA   Chen A.E., Egli D., Niakan K.K., Deng J., Akutsu H., Yamaki M.,
RA   Cowan C.A., Fitz-Gerald C., Zhang K., Melton D.A., Eggan K.C.;
RT   "Optimal timing of inner cell mass isolation increases the efficiency
RT   of human embryonic stem cell derivation and allows generation of
RT   sibling cell lines.";
RL   Cell Stem Cell 4:103-106(2009).
//
RX   PubMed=21295703; DOI=10.1016/j.cell.2010.12.032;
RA   Bock C., Kiskinis E., Verstappen G., Gu H.-C., Boulting G.L., Smith Z.D.,
RA   Ziller M.J., Croft G.F., Amoroso M.W., Oakley D.H., Gnirke A.,
RA   Eggan K.C., Meissner A.;
RT   "Reference maps of human ES and iPS cell variation enable
RT   high-throughput characterization of pluripotent cell lines.";
RL   Cell 144:439-452(2011).
//
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T.G., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:Rs3.1-Rs3.17(2011).
//
RX   PubMed=21637780; DOI=10.1371/journal.pgen.1002085;
RA   Nishino K., Toyoda M., Yamazaki-Inoue M., Fukawatase Y., Chikazawa E.,
RA   Sakaguchi H., Akutsu H., Umezawa A.;
RT   "DNA methylation dynamics in human induced pluripotent stem cells over
RT   time.";
RL   PLoS Genet. 7:E1002085-E1002085(2011).
//
RX   PubMed=29861859; DOI=10.18632/oncotarget.25353;
RA   Panova A.V., Bogomazova A.N., Lagarkova M.A., Kiselev S.L.;
RT   "Epigenetic reprogramming by naive conditions establishes an
RT   irreversible state of partial X chromosome reactivation in female stem
RT   cells.";
RL   Oncotarget 9:25136-25147(2018).
//
RX   PubMed=33360445; DOI=10.1016/j.scr.2020.102134;
RA   Ree D., Borsy A., Fothi A., Orban T.I., Varady G., Erdei Z.,
RA   Sarkadi B., Rethelyi J., Varga N., Apati A.;
RT   "Establishing a human embryonic stem cell clone with a heterozygous
RT   mutation in the DGCR8 gene.";
RL   Stem Cell Res. 50:102134-102134(2021).
//