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Cellosaurus Vero (CVCL_0059)

Cell line name Vero
Synonyms VERO; Verda reno
Accession CVCL_0059
Resource Identification Initiative To cite this cell line use: Vero (RRID:CVCL_0059)
Comments Group: Non-human primate cell line.
Group: Vaccine production cell line.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Biotechnology: Used for the production of the Japanese encephalitis virus (JEV) vaccine (Trade name: IXIARO/JESPECT).
Biotechnology: Used for the production of the inactivated poliovirus vaccine (Trade name: Imovax Polio).
Biotechnology: Used for the production of the Purified Vero-cell Rabies Vaccine (PVRV) (Trade name: VERORAB).
Biotechnology: Used for the production of the Chromatographically Purified Rabies Vaccine (CPRV).
Biotechnology: Used for the production of the live oral rotavirus vaccine (Trade Name: Rotarix).
Biotechnology: Used for the production of the tetravalent dengue vaccine (Trade Name: Dengvaxia).
Omics: Genome sequenced.
Anecdotal: Verda reno means green kidney in Esperanto and Vero means truth also in Esperanto.
Species of origin Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) (NCBI Taxonomy: 60711)
Hierarchy Children:
CVCL_HA73 (BER-40)CVCL_4518 (ECTC)CVCL_RW60 (VD60)
CVCL_L035 (Vero 303)CVCL_0603 (Vero 76)CVCL_L036 (Vero F6)
CVCL_EJ70 (Vero M)CVCL_RX68 (Vero Mx-Luc)CVCL_RX03 (Vero Mx13)
CVCL_JF53 (Vero RCB 10-87)CVCL_1912 (Vero-B4)CVCL_4334 (Vero-Hektor)
CVCL_1K11 (Vero-SF-ACF)CVCL_AS92 (Vero-SF-adapted)CVCL_GA12 (Vero-SV2neo clone VN5)
CVCL_L037 (Vero/hSLAM)CVCL_GA11 (Vero/PPRV H)CVCL_1K13 (Vero/SF)
CVCL_3807 (W162)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages https://en.wikipedia.org/wiki/Vero_cell
https://www.fda.gov/ohrms/dockets/ac/00/backgrd/3616b1a.pdf
http://en.vircell.com/products/vero-cell-line/
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/v/cell-lines-detail-60.html
http://micro.magnet.fsu.edu/primer/techniques/fluorescence/gallery/cells/vero/verocells.html
https://www.phe-culturecollections.org.uk/media/122249/vero-cell-line-profile.pdf
https://www.niid.go.jp/niid/ja/chlamydia-pneumonia-m/818-biochem/5752-vero.html
Publications

CLPUB00126
Yasumura Y., Kawakita Y.
Studies on SV40 in tissue culture: preliminary step for cancer research in vitro.
Nihon Rinsho 21:1201-1219(1963)

PubMed=6027511; DOI=10.3181/00379727-125-32029
Simizu B., Rhim J.S., Wiebenga N.H.
Characterization of the Tacaribe group of arboviruses. I. Propagation and plaque assay of Tacaribe virus in a line of African green monkey kidney cells (Vero).
Proc. Soc. Exp. Biol. Med. 125:119-123(1967)

PubMed=4043530
Whitaker A.M., Hayward C.J.
The characterization of three monkey kidney cell lines.
Dev. Biol. Stand. 60:125-131(1985)

CLPUB00328
Earley E., Johnson K.
The lineage of Vero, Vero 76 and its clone C1008 in the United States.
(In) Vero cells: origin, properties and biomedical applications; Simizu B., Terasima T. (eds.); pp.26-29; Department of Microbiology School of Medicine Chiba University; Chiba (1988)

PubMed=10403033; DOI=10.1006/biol.1998.0156
Lang J., Cetre J.C., Picot N., Lanta M., Briantais P., Vital S., Le Mener V., Lutsch C., Rotivel Y.
Immunogenicity and safety in adults of a new chromatographically purified Vero-cell rabies vaccine (CPRV): a randomized, double-blind trial with purified Vero-cell rabies vaccine (PVRV).
Biologicals 26:299-308(1998)

PubMed=10494966
Montagnon B.J., Vincent-Falquet J.-C., Saluzzo J.-F.
Experience with Vero cells at Pasteur Merieux Connaught.
Dev. Biol. Stand. 98:137-140(1999)

DOI=10.12665/J63.Morgan
Morgan J.H.
Vero cells in vaccine production.
BioProcess. J. 6:12-17(2007)

PubMed=19016439; DOI=10.1002/9780471729259.mca04es11
Ammerman N.C., Beier-Sexton M., Azad A.F.
Growth and maintenance of Vero cell lines.
Curr. Protoc. Microbiol. 11:A.4E.1-A.4E.7(2008)

PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022
Karger A., Bettin B., Lenk M., Mettenleiter T.C.
Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing.
J. Virol. Methods 164:116-121(2010)

PubMed=22059503; DOI=10.1186/1472-6750-11-102
Almeida J.L., Hill C.R., Cole K.D.
Authentication of African green monkey cell lines using human short tandem repeat markers.
BMC Biotechnol. 11:102-102(2011)

PubMed=24975811; DOI=10.1016/j.vaccine.2014.06.045
Donis R.O., Chen I.-M., Davis C.T., Foust A., Hossain M.J., Johnson A., Klimov A., Loughlin R., Xu X., Tsai T., Blayer S., Trusheim H., Colegate T., Fox J., Taylor B., Hussain A., Barr I., Baas C., Louwerens J., Geuns E., Lee M.-S., Venhuizen O., Neumeier E., Ziegler T.
Performance characteristics of qualified cell lines for isolation and propagation of influenza viruses for vaccine manufacturing.
Vaccine 32:6583-6590(2014)

PubMed=25267831; DOI=10.1093/dnares/dsu029
Osada N., Kohara A., Yamaji T., Hirayama N., Kasai F., Sekizuka T., Kuroda M., Hanada K.
The genome landscape of the African green monkey kidney-derived Vero cell line.
DNA Res. 21:673-683(2014)

PubMed=25903999; DOI=10.1002/biot.201400388
Genzel Y.
Designing cell lines for viral vaccine production: where do we stand?
Biotechnol. J. 10:728-740(2015)

Cross-references
Cell line collections AddexBio; P0014002/4920
ATCC; CCL-81
ATCC; CCL-81.4 - Discontinued
ATCC; CRL-6318 - Discontinued
BCRC; 60013
BCRJ; 0245
CCLV; CCLV-RIE 0078
CLS; 605372/p622_VERO
ECACC; 08011101
ECACC; 84113001
ICLC; ATL95005
IZSLER; BS CL 86
JCRB; IFO50471
JCRB; JCRB0111
JCRB; JCRB9013
KCB; KCB 92017YJ
KCLB; 10081
NCBI_Iran; C101
RCB; RCB0001
TKG; TKG 0280
Cell line databases/resources CLDB; cl4643
CLDB; cl4644
CLDB; cl4645
CLDB; cl4648
CLDB; cl4649
CLDB; cl4650
CLDB; cl4651
CLDB; cl5170
CCRID; 3111C0001CCC000060
CCRID; 3111C0002000000001
CCRID; 3131C0001000400010
CCRID; 3142C0001000000029
CCRID; 3153C0001000000035
Lonza; 173
TOKU-E; 3415
Ontologies BTO; BTO:0001444
CLO; CLO_0009524
CLO; CLO_0050515
MCCL; MCC:0000480
MeSH; D014709
Biological sample resources eagle-i; hawaii.eagle-i.net/i/0000012b-5667-e8b1-2f73-b43980000000
Chemistry resources ChEMBL-Cells; CHEMBL3307520
ChEMBL-Targets; CHEMBL391
Other Wikidata; Q3066564