Cellosaurus NCI-H1299 (CVCL_0060)

Cell line name NCI-H1299
Synonyms H1299; H-1299; NCIH1299
Accession CVCL_0060
Resource Identification Initiative To cite this cell line use: NCI-H1299 (RRID:CVCL_0060)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Doubling time: 30 hours (PubMed=25984343).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: HI299; Occasionally.
Disease Large cell lung carcinoma (NCIt: C4450)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_Y296 (H273)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=20679594; PubMed=24335698; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D13S31712
D16S53912,13
D18S5116
D21S1132.2
D3S135817
D5S81811
D7S82010
D8S117910,13
FGA20
Penta D13
Penta E11
TH016,9.3
TPOX8
vWA16,17,18 (ATCC)
16,18 (Cosmic-CLP; PubMed=20679594; PubMed=24335698; PubMed=25877200)
Web pages https://en.wikipedia.org/wiki/H1299
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-15.html
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-173.html
http://tcpaportal.org/mclp/
Publications

PubMed=1563005
Giaccone G., Battey J., Gazdar A.F., Oie H., Draoui M., Moody T.W.
Neuromedin B is present in lung cancer cell lines.
Cancer Res. 52:2732s-2736s(1992)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339
Okabe T., Okamoto I., Tamura K., Terashima M., Yoshida T., Satoh T., Takada M., Fukuoka M., Nakagawa K.
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.
Cancer Res. 67:2046-2053(2007)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20679594; DOI=10.1093/jnci/djq279
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24335698; DOI=10.1093/neuonc/not202
An Q., Fillmore H.L., Vouri M., Pilkington G.J.
Brain tumor cell line authentication, an efficient alternative to capillary electrophoresis by using a microfluidics-based system.
Neuro-oncol. 16:265-273(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-5803
BCRJ; 0185
KCLB; 25803
KCLB; 91299
NCI-DTP; NCI-H1299
Cell line databases/resources CCLE; NCIH1299_LUNG
CCRID; 3111C0002000000050
CCRID; 3131C0001000700160
Cosmic-CLP; 724831
GDSC; 724831
IGRhCellID; H1299GEO
LINCS_LDP; LCL-1609
TOKU-E; 2592
TOKU-E; 3620
Ontologies BTO; BTO:0002552
CLO; CLO_0007986
EFO; EFO_0003043
MCCL; MCC:0000352
Biological sample resources BioSample; SAMN03471642
BioSample; SAMN03471739
Chemistry resources ChEMBL-Cells; CHEMBL3308501
ChEMBL-Targets; CHEMBL612255
Gene expression databases GEO; GSM185871
GEO; GSM206471
GEO; GSM253382
GEO; GSM274743
GEO; GSM274744
GEO; GSM353229
GEO; GSM434266
GEO; GSM784253
GEO; GSM794311
GEO; GSM827467
GEO; GSM844617
GEO; GSM887355
GEO; GSM888433
GEO; GSM1374698
GEO; GSM1374699
GEO; GSM1670165
Other Wikidata; Q5628772
Polymorphism and mutation databases Cosmic; 722069
Cosmic; 724831
Cosmic; 877265
Cosmic; 877418
Cosmic; 903585
Cosmic; 961838
Cosmic; 980971
Cosmic; 1004693
Cosmic; 1032443
Cosmic; 1047106
Cosmic; 1066159
Cosmic; 1146875
Cosmic; 1154606
Cosmic; 1175867
Cosmic; 1218870
Cosmic; 1239925
Cosmic; 1609524
Cosmic; 1870264
Cosmic; 1925845
Cosmic; 1995520
Cosmic; 2042873
Cosmic; 2125178
Cosmic; 2630419