ID   HEK293T
AC   CVCL_0063
SY   Hek293T; HEK-293T; HEK 293T; HEK-293-T; HEK 293 T; 293-T; 293 T; 293T; Human Embryonic Kidney 293T; 293tsA1609neo
DR   BTO; BTO:0002181
DR   CLO; CLO_0050894
DR   EFO; EFO_0001082
DR   EFO; EFO_0001184
DR   CLDB; cl7154
DR   Abcam; ab255449
DR   Abcam; ab255593
DR   Abcam; ab282205
DR   AddexBio; T0011002/445
DR   ATCC; CRL-3216
DR   BioGRID_ORCS_Cell_line; 267
DR   BioSample; SAMN01821609
DR   BioSample; SAMN03473454
DR   BioSamples; SAMEA2168958
DR   BioSamples; SAMEA2536418
DR   BioSamples; SAMEA2536419
DR   CCLV; CCLV-RIE 1018
DR   CCRID; 1101HUM-PUMC000091
DR   CCRID; 3101HUMGNHu17
DR   CCRID; 3101HUMSCSP502
DR   CCRID; 4201HUM-CCTCC00187
DR   CCRID; 5301HUM-KCB07044YJ
DR   CCTCC; GDC0187
DR   ChEMBL-Cells; CHEMBL3706569
DR   ChEMBL-Targets; CHEMBL3706568
DR   CLS; 300189
DR   Cosmic; 1326280
DR   Cosmic; 2440479
DR   DSMZ; ACC-635
DR   DSMZCellDive; ACC-635
DR   ECACC; 12022001
DR   ENCODE; ENCBS276VDW
DR   ENCODE; ENCBS319KKV
DR   ENCODE; ENCBS323RYE
DR   ENCODE; ENCBS582KZL
DR   ENCODE; ENCBS634AAA
DR   ENCODE; ENCBS986WKD
DR   FCS-free; 6-2-482-1-4-3
DR   GEO; GSM1008573
DR   GEO; GSM5936927
DR   GEO; GSM5936928
DR   GEO; GSM5936929
DR   IBRC; C10683
DR   ICLC; HTL04001
DR   KCB; KCB 200744YJ
DR   Lonza; 504
DR   MeSH; D057809
DR   NCBI_Iran; C498
DR   NCBI_Iran; C644
DR   PRIDE; PXD000593
DR   PRIDE; PXD001062
DR   PRIDE; PXD001165
DR   PRIDE; PXD001609
DR   PRIDE; PXD004452
DR   PRIDE; PXD006633
DR   PRIDE; PXD006698
DR   PRIDE; PXD012357
DR   PRIDE; PXD013232
DR   PRIDE; PXD016924
DR   PRIDE; PXD018162
DR   PRIDE; PXD018182
DR   PRIDE; PXD019204
DR   PRIDE; PXD028149
DR   PRIDE; PXD029242
DR   PRIDE; PXD029738
DR   PRIDE; PXD030166
DR   PubChem_Cell_line; CVCL_0063
DR   RCB; RCB2202
DR   TOKU-E; 3537
DR   Ubigene; YC-A006
DR   Ubigene; YC-A007
DR   Wikidata; Q27546876
RX   DOI=10.13005/bpj/1414;
RX   PubMed=3031469;
RX   PubMed=15900046;
RX   PubMed=25182477;
RX   PubMed=26694163;
RX   PubMed=28196595;
RX   PubMed=28601559;
RX   PubMed=29468137;
RX   PubMed=34800366;
WW   https://en.wikipedia.org/wiki/293T
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/HEK293T_Crawford_protocol.pdf
WW   http://hek293genome.org/v2/
WW   https://www.atcc.org/en/support/technical-support/faqs/growth-medium-for-crl-3216
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/2/cell-lines-detail-153.html
WW   https://www.fishersci.com/shop/products/hek293t-cell-line-hcl4517/nc0260915
WW   http://www.genhunter.com/products/293t-cells.html
WW   https://tcpaportal.org/mclp/
CC   Part of: ENCODE project common cell types; tier 3.
CC   Part of: MD Anderson Cell Lines Project.
CC   Virology: Highly susceptible to infection by Zika virus (ZIKV) (PubMed=29468137).
CC   Doubling time: ~24-30 hours (DSMZ=ACC-635).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=tsA].
CC   Omics: Deep proteome analysis.
CC   Omics: Genome sequenced.
CC   Omics: miRNA expression profiling.
CC   Omics: Mitochondrial proteome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Misspelling: HECK293T; Note=Occasionally.
CC   Misspelling: HEK 239T; Note=Occasionally.
CC   Misspelling: HEK239T; Note=Occasionally.
CC   Misspelling: HEK-393T; Note=Occasionally.
CC   Misspelling: HEK393T; Note=Occasionally.
CC   Misspelling: 239T; Note=Occasionally.
CC   Misspelling: 393T; Note=Occasionally.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
ST   Source(s): ATCC; CCRID; DSMZ; ECACC; Genomics_Center_BCF_Technion; RCB
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D10S1248: 14
ST   D12S391: 19,21
ST   D13S317: 12 (ECACC)
ST   D13S317: 12,14 (ATCC; CCRID; DSMZ; Genomics_Center_BCF_Technion; RCB)
ST   D16S539: 9,13
ST   D18S51: 17,18
ST   D19S433: 18
ST   D1S1656: 15,17.3
ST   D21S11: 28,30.2
ST   D22S1045: 16
ST   D2S1338: 19
ST   D2S441: 11,15
ST   D3S1358: 15,16,17 (CCRID)
ST   D3S1358: 15,17 (DSMZ; Genomics_Center_BCF_Technion)
ST   D5S818: 8,9
ST   D7S820: 11
ST   D8S1179: 12,14
ST   FGA: 23
ST   Penta D: 9,10
ST   Penta E: 7,15
ST   TH01: 7,9.3
ST   TPOX: 11
ST   vWA: 16,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0045 ! HEK293
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 42
//
RX   DOI=10.13005/bpj/1414;
RA   Yuan J., Xu W.W.-Y., Jiang S.Y.-L., Yu H.X.-Y., Poon H.-F.;
RT   "The scattered twelve tribes of HEK293.";
RL   Biomed. Pharmacol. J. 11:621-623(2018).
//
RX   PubMed=3031469; DOI=10.1128/mcb.7.1.379-387.1987;
RA   DuBridge R.B., Tang P., Hsia H.-C., Leong P.-M., Miller J.H.,
RA   Calos M.P.;
RT   "Analysis of mutation in human cells by using an Epstein-Barr virus
RT   shuttle system.";
RL   Mol. Cell. Biol. 7:379-387(1987).
//
RX   PubMed=15900046; DOI=10.1093/jnci/dji133;
RA   Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y.,
RA   Yamazaki K., Hamada J.-i., Tada M., Moriuchi T., Ishikawa Y., Kato Y.,
RA   Tomoda H., Yamori T., Tsuruo T.;
RT   "p53-defective tumors with a functional apoptosome-mediated pathway: a
RT   new therapeutic target.";
RL   J. Natl. Cancer Inst. 97:765-777(2005).
//
RX   PubMed=25182477; DOI=10.1038/ncomms5767;
RA   Lin Y.-C., Boone M., Meuris L., Lemmens I., Van Roy N., Soete A.,
RA   Reumers J., Moisse M., Plaisance S., Drmanac R., Chen J., Speleman F.,
RA   Lambrechts D., Van de Peer Y., Tavernier J., Callewaert N.;
RT   "Genome dynamics of the human embryonic kidney 293 lineage in response
RT   to cell biology manipulations.";
RL   Nat. Commun. 5:4767.1-4767.12(2014).
//
RX   PubMed=26694163; DOI=10.1371/journal.pone.0144924;
RA   Janiszewska J., Szaumkessel M., Kostrzewska-Poczekaj M., Bednarek K.,
RA   Paczkowska J., Jackowska J., Grenman R., Szyfter K., Wierzbicka M.,
RA   Giefing M., Jarmuz-Szymczak M.;
RT   "Global miRNA expression profiling identifies miR-1290 as novel
RT   potential oncomiR in laryngeal carcinoma.";
RL   PLoS ONE 10:E0144924-E0144924(2015).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=28601559; DOI=10.1016/j.cels.2017.05.009;
RA   Bekker-Jensen D.B., Kelstrup C.D., Batth T.S., Larsen S.C.,
RA   Haldrup C., Bramsen J.B., Sorensen K.D., Hoyer S., Orntoft T.F.,
RA   Andersen C.L., Nielsen M.L., Olsen J.V.;
RT   "An optimized shotgun strategy for the rapid generation of
RT   comprehensive human proteomes.";
RL   Cell Syst. 4:587-599.e4(2017).
//
RX   PubMed=29468137; DOI=10.5501/wjv.v7.i1.10;
RA   Himmelsbach K., Hildt E.;
RT   "Identification of various cell culture models for the study of Zika
RT   virus.";
RL   World J. Virol. 7:10-20(2018).
//
RX   PubMed=34800366; DOI=10.1016/j.cmet.2021.11.001;
RA   Morgenstern M., Peikert C.D., Lubbert P., Suppanz I., Klemm C.,
RA   Alka O., Steiert C., Naumenko N., Schendzielorz A., Melchionda L.,
RA   Muhlhauser W.W.D., Knapp B., Busch J.D., Stiller S.B., Dannenmaier S.,
RA   Lindau C., Licheva M., Eickhorst C., Galbusera R., Zerbes R.M.,
RA   Ryan M.T., Kraft C., Kozjak-Pavlovic V., Drepper F., Dennerlein S.,
RA   Oeljeklaus S., Pfanner N., Wiedemann N., Warscheid B.;
RT   "Quantitative high-confidence human mitochondrial proteome and its
RT   dynamics in cellular context.";
RL   Cell Metab. 33:2464-2483.e18(2021).
//