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Cellosaurus MV4-11 (CVCL_0064)

[Text version]

Cell line name MV4-11
Synonyms MV-4-11; MV-4:11; MV4:11; MV 4;11; MV4;11; MV411; MV4II
Accession CVCL_0064
Resource Identification Initiative To cite this cell line use: MV4-11 (RRID:CVCL_0064)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 32 hours (PubMed=25984343); ~48 hours (CLS); ~50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Acetylation analysis by proteomics.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations FLT3 internal tandem duplication (FLT3-ITD) (PubMed=12529668).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; CLS; COG; Cosmic-CLP; DSMZ; PubMed=20922763; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133824,25
D3S135816,17
D5S81811,12
D7S8208,9
D8S117913
D13S31713
D16S53911,12
D18S5111,17
D19S43315
D21S1132,32.2 (CLS; COG; PubMed=25877200)
32.2 (PubMed=20922763)
FGA19,21
Penta D9,10
Penta E7,18
TH018,9.3
TPOX8,11
vWA14,15

Run an STR similarity search on this cell line
Web pages http://www.infarktforschung.de/macrophages_cell_lines.html
Publications

DOI=10.1007/978-1-4757-1647-4_13
Biedler J.L.
Chromosome abnormalities in human tumor cells in culture.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975)

PubMed=3496132
Lange B., Valtieri M., Santoli D., Caracciolo D., Mavilio F., Gemperlein I., Griffin C., Emanuel B.S., Finan J., Nowell P.C., Rovera G.
Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines.
Blood 70:192-199(1987)

PubMed=2656885; DOI=10.1002/stem.5530070202
Ihle J.N., Askew D.
Origins and properties of hematopoietic growth factor-dependent cell lines.
Int. J. Cell Cloning 7:68-91(1989)

PubMed=8353274
Chen C.-S., Hilden J.M., Frestedt J., Domer P.H., Moore R., Korsmeyer S.J., Kersey J.H.
The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.
Blood 82:1080-1085(1993)

PubMed=8358709
Hilden J.M., Chen C.-S., Moore R., Frestedt J., Kersey J.H.
Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia.
Cancer Res. 53:3853-3866(1993)

PubMed=12529668; DOI=10.1038/sj.leu.2402740
Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.
FLT3 mutations in acute myeloid leukemia cell lines.
Leukemia 17:120-124(2003)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R., Tsuchida M., Sugita K., Ida K., Hayashi Y.
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Drexler H.G., Quentmeier H., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=19608861; DOI=10.1126/science.1175371
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science 325:834-840(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20922763; DOI=10.1002/pbc.22801
Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J., Reynolds C.P.
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections AddexBio; C0003025/4955
ATCC; CRL-9591
ATCC; HTB-189 - Discontinued
CLS; 300295/p637_MV4-11
DSMZ; ACC-102
Cell line databases/resources CLDB; cl3610
CLDB; cl3611
CCLE; MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00657
Cosmic-CLP; 908156
GDSC; 908156
IGRhCellID; MV4II
LINCS_LDP; LCL-1092
Lonza; 996
TOKU-E; 2536
Ontologies BTO; BTO:0004479
CLO; CLO_0007906
EFO; EFO_0002242
Biological sample resources BioSample; SAMN01821582
BioSample; SAMN01821649
BioSample; SAMN03473104
Chemistry resources ChEMBL-Cells; CHEMBL3308063
ChEMBL-Targets; CHEMBL613835
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM236796
GEO; GSM236832
GEO; GSM482560
GEO; GSM887344
GEO; GSM888420
GEO; GSM1374694
GEO; GSM1446746
GEO; GSM1670137
Other Wikidata; Q54907109
Polymorphism and mutation databases Cosmic; 787416
Cosmic; 798673
Cosmic; 908156
Cosmic; 975284
Cosmic; 994182
Cosmic; 996315
Cosmic; 1012104
Cosmic; 1037736
Cosmic; 1078732
Cosmic; 1089516
Cosmic; 1127256
Cosmic; 1150899
Cosmic; 1152712
Cosmic; 1181603
Cosmic; 1278781
Cosmic; 1281340
Cosmic; 1308221
Cosmic; 1319550
Cosmic; 1451846
Cosmic; 1476424
Cosmic; 1516631
Cosmic; 1524837
Cosmic; 1623635
Cosmic; 1696137
Cosmic; 1779133
Cosmic; 2131568
Cosmic; 2306226
Cosmic; 2392908
Cosmic; 2393011
Cosmic; 2542841