ID   MV4-11
AC   CVCL_0064
SY   MV-4-11; MV-4:11; MV4:11; MV 4;11; MV4;11; MV411; MV(4;11); MV4II
DR   BTO; BTO:0006413
DR   CLO; CLO_0007906
DR   EFO; EFO_0002242
DR   CLDB; cl3610
DR   CLDB; cl3611
DR   AddexBio; C0003025/4955
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-9591
DR   ATCC; HTB-189
DR   BioGRID_ORCS_Cell_line; 138
DR   BioSample; SAMN01821582
DR   BioSample; SAMN01821649
DR   BioSample; SAMN03473104
DR   BioSample; SAMN10988366
DR   cancercelllines; CVCL_0064
DR   CCRID; 3101HUMSCSP5031
DR   Cell_Model_Passport; SIDM00657
DR   ChEMBL-Cells; CHEMBL3308063
DR   ChEMBL-Targets; CHEMBL613835
DR   CLS; 300295
DR   Cosmic; 787416
DR   Cosmic; 798673
DR   Cosmic; 908156
DR   Cosmic; 975284
DR   Cosmic; 994182
DR   Cosmic; 996315
DR   Cosmic; 1012104
DR   Cosmic; 1037736
DR   Cosmic; 1078732
DR   Cosmic; 1089516
DR   Cosmic; 1127256
DR   Cosmic; 1150899
DR   Cosmic; 1152712
DR   Cosmic; 1181603
DR   Cosmic; 1278781
DR   Cosmic; 1281340
DR   Cosmic; 1308221
DR   Cosmic; 1319550
DR   Cosmic; 1451846
DR   Cosmic; 1476424
DR   Cosmic; 1516631
DR   Cosmic; 1524837
DR   Cosmic; 1623635
DR   Cosmic; 1696137
DR   Cosmic; 1779133
DR   Cosmic; 2131568
DR   Cosmic; 2306226
DR   Cosmic; 2392908
DR   Cosmic; 2393011
DR   Cosmic; 2542841
DR   Cosmic; 2750867
DR   Cosmic-CLP; 908156
DR   DepMap; ACH-000045
DR   DSMZ; ACC-102
DR   DSMZCellDive; ACC-102
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   EGA; EGAS00001002554
DR   GDSC; 908156
DR   GEO; GSM236796
DR   GEO; GSM236832
DR   GEO; GSM482560
DR   GEO; GSM887344
DR   GEO; GSM888420
DR   GEO; GSM1374694
DR   GEO; GSM1446746
DR   GEO; GSM1670137
DR   IARC_TP53; 21521
DR   IGRhCellID; MV4II
DR   LiGeA; CCLE_055
DR   LINCS_LDP; LCL-1092
DR   Lonza; 996
DR   PharmacoDB; MV411_972_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0064
DR   PubChem_Cell_line; CVCL_0064
DR   TOKU-E; 2536
DR   Ubigene; YC-C060
DR   Wikidata; Q54907109
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1423625;
RX   PubMed=2656885;
RX   PubMed=3496132;
RX   PubMed=8353274;
RX   PubMed=8358709;
RX   PubMed=9195772;
RX   PubMed=12529668;
RX   PubMed=14504097;
RX   PubMed=14671638;
RX   PubMed=15843827;
RX   PubMed=16408098;
RX   PubMed=19608861;
RX   PubMed=20215515;
RX   PubMed=20922763;
RX   PubMed=21552520;
RX   PubMed=22460905;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25984343;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=35839778;
WW   https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9591.
CC   Population: Caucasian.
CC   Characteristics: CSF2 and IL3 dependent.
CC   Doubling time: 32 hours (PubMed=25984343); ~48 hours (CLS=300295); ~50 hours (DSMZ=ACC-102).
CC   HLA typing: A*03:01,68:01; B*14:02,18:01; C*08:02,15:02; DQA1*01:02,01:02; DQB1*06:05,06:05; DRB1*01:01,13:02 (PubMed=26589293).
CC   HLA typing: A*03:01:01,20:01:02; B*14:02:01,18:01:01; C*08:02:01,15:02:01; DPB1*02:01,04:01; DQA1*01:01:01,01:02:01; DQB1*05:01:01,06:09:01; DRB1*01:01:01,13:02:01 (CLS=300295).
CC   Karyotypic information: 48,XY,t(4;11)(q21;q23),+8,+19 (ATCC=CRL-9591).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene fusion; HGNC; 7135; AFF1 + HGNC; 7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 (PubMed=1423625; PubMed=8358709).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Unexplicit; Internal tandem duplication (FLT3-ITD); ClinVar=VCV000016270; Zygosity=Unspecified (PubMed=12529668).
CC   Omics: Acetylation analysis by proteomics.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative phosphoproteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.59%; Native American=0%; East Asian, North=0.34%; East Asian, South=0%; South Asian=2.57%; European, North=67.58%; European, South=28.91% (PubMed=30894373).
CC   Discontinued: ATCC; HTB-189; true.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): AddexBio; ATCC; CLS; COG; Cosmic-CLP; DSMZ; PubMed=20922763; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 13
ST   D16S539: 11,12
ST   D18S51: 11,17
ST   D19S433: 15
ST   D21S11: 32 (DSMZ)
ST   D21S11: 32,32.2 (CLS; COG; PubMed=25877200)
ST   D21S11: 32.2 (PubMed=20922763)
ST   D2S1338: 24,25
ST   D3S1358: 16,17
ST   D5S818: 11,12
ST   D7S820: 8,9
ST   D8S1179: 13
ST   FGA: 19,21
ST   Penta D: 9,10
ST   Penta E: 7,18
ST   TH01: 8,9.3
ST   TPOX: 8,11
ST   vWA: 14,15
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   10Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 45
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=1423625; DOI=10.1016/0092-8674(92)90603-A;
RA   Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G.,
RA   Croce C.M., Canaani E.;
RT   "The t(4;11) chromosome translocation of human acute leukemias fuses
RT   the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.";
RL   Cell 71:701-708(1992).
//
RX   PubMed=2656885; DOI=10.1002/stem.5530070202;
RA   Ihle J.N., Askew D.;
RT   "Origins and properties of hematopoietic growth factor-dependent cell
RT   lines.";
RL   Int. J. Cell Cloning 7:68-91(1989).
//
RX   PubMed=3496132; DOI=10.1182/blood.V70.1.192.192;
RA   Lange B., Valtieri M., Santoli D., Caracciolo D., Mavilio F.,
RA   Gemperlein I., Griffin C.A., Emanuel B.S., Finan J., Nowell P.C.,
RA   Rovera G.;
RT   "Growth factor requirements of childhood acute leukemia: establishment
RT   of GM-CSF-dependent cell lines.";
RL   Blood 70:192-199(1987).
//
RX   PubMed=8353274; DOI=10.1182/blood.V82.4.1080.1080;
RA   Chen C.-S., Hilden J.M., Frestedt J., Domer P.H., Moore R.,
RA   Korsmeyer S.J., Kersey J.H.;
RT   "The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal
RT   tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute
RT   leukemia.";
RL   Blood 82:1080-1085(1993).
//
RX   PubMed=8358709;
RA   Hilden J.M., Chen C.-S., Moore R., Frestedt J., Kersey J.H.;
RT   "Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the
RT   polymerase chain reaction in t(4;11) acute leukemia.";
RL   Cancer Res. 53:3853-3866(1993).
//
RX   PubMed=9195772;
RA   Tohyama K.;
RT   "Human factor-dependent leukemia cell lines.";
RL   Int. J. Hematol. 65:309-317(1997).
//
RX   PubMed=12529668; DOI=10.1038/sj.leu.2402740;
RA   Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.;
RT   "FLT3 mutations in acute myeloid leukemia cell lines.";
RL   Leukemia 17:120-124(2003).
//
RX   PubMed=14504097; DOI=10.1182/blood-2003-02-0418;
RA   Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R.,
RA   Tsuchida M., Sugita K., Ida K., Hayashi Y.;
RT   "FLT3 mutations in the activation loop of tyrosine kinase domain are
RT   frequently found in infant ALL with MLL rearrangements and pediatric
RT   ALL with hyperdiploidy.";
RL   Blood 103:1085-1088(2004).
//
RX   PubMed=14671638; DOI=10.1038/sj.leu.2403236;
RA   Drexler H.G., Quentmeier H., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   MLL gene alterations.";
RL   Leukemia 18:227-232(2004).
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J.,
RA   Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M.,
RA   Fioretos T.;
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=16408098; DOI=10.1038/sj.leu.2404081;
RA   Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.;
RT   "JAK2 V617F tyrosine kinase mutation in cell lines derived from
RT   myeloproliferative disorders.";
RL   Leukemia 20:471-476(2006).
//
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA   Walther T.C., Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=20922763; DOI=10.1002/pbc.22801;
RA   Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J.,
RA   Reynolds C.P.;
RT   "National Cancer Institute pediatric preclinical testing program:
RT   model description for in vitro cytotoxicity testing.";
RL   Pediatr. Blood Cancer 56:239-249(2011).
//
RX   PubMed=21552520; DOI=10.1371/journal.pone.0019169;
RA   Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S.A.,
RA   Tucker M., Kornhauser J.M., Ren J.-M., MacNeill J., Gygi S.P.,
RA   Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.;
RT   "Survey of activated FLT3 signaling in leukemia.";
RL   PLoS ONE 6:E19169-E19169(2011).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.,
RA   Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404;
RA   Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.;
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:E0210404-E0210404(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//