Cellosaurus Jurkat (CVCL_0065)

Cell line name Jurkat
Synonyms JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024
Accession CVCL_0065
Resource Identification Initiative To cite this cell line use: Jurkat (RRID:CVCL_0065)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: ENCODE project common cell types; tier 3.
Part of: International Histocompatibility Workshop cell lines.
Doubling time: 26 hours (PubMed=17117183); ~25-35 hours (DSMZ).
Microsatellite instability: Instable (MSI-high) (Sanger).
Omics: Acetylation analysis by proteomics.
Omics: Deep exome analysis.
Omics: Deep phosphoproteome analysis.
Omics: Deep proteome analysis.
Omics: DNA methylation analysis.
Omics: N-glycan profiling.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Virome analysis using proteomics.
Misspelling: JURKET; In PubMed=313568.
Derived from sampling site: Peripheral blood.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_1061 (A3); CVCL_U618 (BCL2 (AAA) Jurkat); CVCL_U619 (BCL2 (S70A) Jurkat); CVCL_U620 (BCL2 (S87A) Jurkat); CVCL_U617 (BCL2 Jurkat); CVCL_KS58 (CellSensor CRE-bla Jurkat); CVCL_KS63 (CellSensor ISRE-bla Jurkat); CVCL_KB42 (CellSensor NFAT-bla Jurkat); CVCL_KB43 (CellSensor NFkB-bla Jurkat); CVCL_U426 (Flp-In-Jurkat); CVCL_LB63 (GloResponse NFAT-RE-luc2 Jurkat); CVCL_2461 (H33HJ-JA1); CVCL_U324 (J-A1886); CVCL_1H08 (J-Jhan); CVCL_8281 (J-Lat 10.6); CVCL_8282 (J-Lat 15.4); CVCL_8280 (J-Lat 6.3); CVCL_8284 (J-Lat 8.4); CVCL_8285 (J-Lat 9.2); CVCL_1H28 (J-Lat GFP Clone A72); CVCL_1G41 (J-Lat Tat-GFP Clone 82); CVCL_1G42 (J-Lat Tat-GFP Clone A1); CVCL_1G43 (J-Lat Tat-GFP Clone A2); CVCL_1G44 (J-Lat Tat-GFP Clone A7); CVCL_1G45 (J-Lat Tat-GFP Clone H2); CVCL_8279 (J1.1); CVCL_R861 (J14); CVCL_1Y74 (JinB8); CVCL_2966 (JKT-beta-del); CVCL_4V24 (JL/AMSA); CVCL_1E01 (JLTRG); CVCL_0D86 (JPX-9); CVCL_IR10 (Jurkat 1G4); CVCL_3502 (Jurkat D1.1); CVCL_0367 (Jurkat E6.1); CVCL_4530 (Jurkat J6); CVCL_KU30 (Jurkat KZ142 clone #24); CVCL_EG05 (Jurkat R3.25); CVCL_KU38 (Jurkat Tet-Off); CVCL_KU35 (Jurkat Tet-On); CVCL_V356 (Jurkat Tet-On 3G); CVCL_W813 (Jurkat tet-on clone 1); CVCL_W814 (Jurkat tet-on clone 2); CVCL_0584 (Jurkat Wurzburg); CVCL_U326 (Jurkat-111); CVCL_1G47 (Jurkat-522 F/Y); CVCL_1G48 (Jurkat-7/3 STOP); CVCL_6925 (Jurkat-77); CVCL_U323 (Jurkat-99); CVCL_X703 (Jurkat-A2); CVCL_1G46 (Jurkat-deltaKS); CVCL_X593 (Jurkat-Dual); CVCL_JZ99 (Jurkat-F9-1906LUC); CVCL_1F94 (Jurkat-HXBc2(4)); CVCL_1F95 (Jurkat-HXBc2(6)); CVCL_B332 (Jurkat-JMN); CVCL_KS47 (Jurkat-Lucia NFAT); CVCL_C831 (Jurkat-TAg); CVCL_X692 (Jurkat-tat); CVCL_AR84 (Jurkat/A4); CVCL_L807 (MDS); CVCL_8894 (MHH225); CVCL_U621 (Neo Jurkat); CVCL_KZ68 (PathHunter Jurkat IkappaB Degradation); CVCL_1H23 (PPIA-/- Jurkat)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): COG; Cosmic-CLP; DSMZ; ECACC; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO11,12 (COG; TKG)
10,11 (Cosmic-CLP; DSMZ)
10,12 (ECACC)
9,10,11 (RCB_RCB0537)
11 (RCB_RCB0806)
D13S3178,11 (COG; Cosmic-CLP; DSMZ; ECACC; RCB_RCB0537)
8,11,12 (RCB_RCB0806)
8,10,11 (TKG)
D16S53911 (COG; Cosmic-CLP; DSMZ; RCB_RCB0806; TKG)
10,11 (ECACC; RCB_RCB0537)
D18S5113,21
D19S43313,15.2
D21S1131.2,32.2
D2S133819,23
D3S135815,16,17
D5S8189
D7S8208,10 (COG; ECACC; RCB_RCB0537; TKG)
8,10,11 (Cosmic-CLP; DSMZ; RCB_RCB0806)
D8S117912,14,15
FGA20,22
TH016,9.3
TPOX8,10 (COG; Cosmic-CLP; DSMZ; ECACC; RCB_RCB0806; TKG)
8,9,10 (RCB_RCB0537)
vWA17,18,19 (COG; DSMZ)
18,19,20 (Cosmic-CLP)
16,17,19,20 (ECACC)
16,17,18 (RCB_RCB0537; RCB_RCB0806)
18,20 (TKG)
Web pages https://en.wikipedia.org/wiki/Jurkat_cells
http://www.cells-talk.com/index.php/page/copelibrary?key=Jurkat
http://141.61.102.20/mxdb/project/show/9191407937500
http://genome.ucsc.edu/ENCODE/protocols/cell/human/Jurkat_protocol.pdf
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/j/cell-lines-detail-7.html
Publications

PubMed=68013; DOI=10.1002/ijc.2910190505
Schneider U., Schwenk H.-U., Bornkamm G.W.
Characterization of EBV-genome negative 'null' and 'T' cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma.
Int. J. Cancer 19:621-626(1977)

PubMed=3165345
LaGree K.A., Lee A.T., Stetten G., Strauss P.R.
The human Jurkat (FHCRC-11) cell line is heterogeneous in ploidy and cell size and releases detergent-soluble DNA.
Exp. Hematol. 16:686-690(1988)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Siebert R., Willers C.P., Schramm A., Fossa A., Dresen I.M.G., Uppenkamp M., Nowrousian M.R., Seeber S., Opalka B.
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=9685479; DOI=10.1093/nar/26.16.3651
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Kawamura M., Ohnishi H., Guo S.X., Sheng X.M., Minegishi M., Hanada R., Horibe K., Hongo T., Kaneko Y., Bessho F., Yanagisawa M., Sekiya T., Hayashi Y.
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x
Kamimura K., Hojo H., Abe M.
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.
Pathol. Int. 54:224-230(2004)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17117183; DOI=10.1038/sj.bjc.6603447
Beesley A.H., Palmer M.-L., Ford J., Weller R.E., Cummings A.J., Freitas J.R., Firth M.J., Perera K.U., de Klerk N.H., Kees U.R.
Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines.
Br. J. Cancer 95:1537-1544(2006)

PubMed=19608861; DOI=10.1126/science.1175371
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science 325:834-840(2009)

PubMed=22278370; DOI=10.1074/mcp.M111.014050
Geiger T., Wehner A., Schaab C., Cox J., Mann M.
Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins.
Mol. Cell. Proteomics 11:M111.014050-M111.014050(2012)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22675565; DOI=10.1371/journal.pone.0038463
Kalender Atak Z., De Keersmaecker K., Gianfelici V., Geerdens E., Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G., Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P., Cools J., Aerts S.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:E38463-E38463(2012)

PubMed=22944676; DOI=10.1515/hsz-2012-0195
Reinke S.O., Bayer M., Berger M., Hinderlich S., Blanchard V.
The analysis of N-glycans of cell membrane proteins from human hematopoietic cell lines reveals distinctions in their pattern.
Biol. Chem. 393:731-747(2012)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=24618588; DOI=10.1371/journal.pone.0091433
Chernobrovkin A.L., Zubarev R.A.
Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins.
PLoS ONE 9:E91433-E91433(2014)

PubMed=26074081; DOI=10.1016/j.celrep.2015.05.029
Giansanti P., Aye T.T., van den Toorn H., Peng M., van Breukelen B., Heck A.J.R.
An augmented multiple-protease-based human phosphopeptide atlas.
Cell Rep. 11:1834-1843(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-282
ECACC; 86010201
ICLC; HTL01002 - Discontinued
IZSLER; BS CL 131
KCB; KCB 94018YJ
NCBI_Iran; C120
NIH-ARP; 4668-165
RCB; RCB0537
RCB; RCB0806
RCB; RCB3052
TKG; TKG 0209
Cell line databases/resources CLDB; cl2950
CLDB; cl2959
CLDB; cl2960
CLDB; cl2961
CLDB; cl5212
CCLE; JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CCRID; 3111C0001CCC000347
Cosmic-CLP; 998184
GDSC; 998184
IHW; IHW00002
LINCS_LDP; LCL-2107
Lonza; 142
TOKU-E; 3710
Ontologies BTO; BTO:0000661
CLO; CLO_0007029
CLO; CLO_0007043
CLO; CLO_0050978
CLO; CLO_0050993
CLO; CLO_0051001
EFO; EFO_0002796
MCCL; MCC:0000503
MeSH; D019169
Biological sample resources BioSample; SAMN03472181
BioSample; SAMN03472286
BioSample; SAMN03473341
Chemistry resources ChEMBL-Cells; CHEMBL3307526
ChEMBL-Targets; CHEMBL397
Gene expression databases GEO; GSM1991
GEO; GSM236783
GEO; GSM236819
GEO; GSM482494
GEO; GSM887188
GEO; GSM888261
GEO; GSM1040307
GEO; GSM1040377
GEO; GSM1374580
GEO; GSM1669965
Other Wikidata; Q1632589
Polymorphism and mutation databases Cosmic; 683539
Cosmic; 721707
Cosmic; 755289
Cosmic; 801727
Cosmic; 850196
Cosmic; 913426
Cosmic; 919152
Cosmic; 922675
Cosmic; 933540
Cosmic; 991544
Cosmic; 998737
Cosmic; 999757
Cosmic; 1012072
Cosmic; 1037693
Cosmic; 1115592
Cosmic; 1118463
Cosmic; 1118464
Cosmic; 1127262
Cosmic; 1130236
Cosmic; 1132774
Cosmic; 1175129
Cosmic; 1191689
Cosmic; 1224368
Cosmic; 1226860
Cosmic; 1330489
Cosmic; 1375588
Cosmic; 1483364
Cosmic; 1524798
Cosmic; 1639637
Cosmic; 1641380
Cosmic; 1664522
Cosmic; 1760524
Cosmic; 1811157
Cosmic; 2039520
Cosmic; 2165713
Cosmic; 2301569
Cosmic; 2361366
Cosmic; 2602916
Proteomic databases PRIDE; PRD000008
PRIDE; PRD000013
PRIDE; PRD000787
PRIDE; PXD000426
PRIDE; PXD001428
PRIDE; PXD002091
PRIDE; PXD002395