ID   SNU-16
AC   CVCL_0076
SY   SNU16; NCI-SNU-16
DR   BTO; BTO:0004987
DR   CLO; CLO_0009095
DR   EFO; EFO_0002344
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-5974
DR   BCRC; 60212
DR   BioSample; SAMN03473127
DR   BioSample; SAMN10987911
DR   CCLE; SNU16_STOMACH
DR   Cell_Model_Passport; SIDM01145
DR   ChEMBL-Cells; CHEMBL3307273
DR   ChEMBL-Targets; CHEMBL613529
DR   Cosmic; 685588
DR   Cosmic; 687558
DR   Cosmic; 737365
DR   Cosmic; 848138
DR   Cosmic; 887247
DR   Cosmic; 908446
DR   Cosmic; 921597
DR   Cosmic; 1067204
DR   Cosmic; 1090452
DR   Cosmic; 1154649
DR   Cosmic; 1187295
DR   Cosmic; 1294962
DR   Cosmic; 1528873
DR   Cosmic; 1995596
DR   Cosmic; 2069774
DR   Cosmic; 2373751
DR   Cosmic; 2443799
DR   Cosmic; 2484966
DR   Cosmic; 2646590
DR   Cosmic-CLP; 908446
DR   DepMap; ACH-000581
DR   GDSC; 908446
DR   GEO; GSM267423
DR   GEO; GSM267430
DR   GEO; GSM267437
DR   GEO; GSM267444
DR   GEO; GSM552373
DR   GEO; GSM562407
DR   GEO; GSM827556
DR   GEO; GSM828829
DR   GEO; GSM844702
DR   GEO; GSM887611
DR   GEO; GSM888695
DR   GEO; GSM1237680
DR   GEO; GSM1237705
DR   GEO; GSM1374886
DR   GEO; GSM1670274
DR   IARC_TP53; 306
DR   IARC_TP53; 30160
DR   IGRhCellID; SNU16
DR   KCLB; 00016
DR   LiGeA; CCLE_312
DR   LINCS_LDP; LCL-1889
DR   PharmacoDB; SNU16_1446_2019
DR   Wikidata; Q54955122
RX   DOI=10.1016/B978-0-12-333530-2.50014-9;
RX   PubMed=1676761;
RX   PubMed=2158397;
RX   PubMed=8806092;
RX   PubMed=8806095;
RX   PubMed=10674020;
RX   PubMed=14720123;
RX   PubMed=19956504;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=23637631;
RX   PubMed=24807215;
RX   PubMed=25485619;
RX   PubMed=25960936;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31395879;
WW   http://tcpaportal.org/mclp/
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: FGFR genetic alteration cell panel (ATCC TCP-1034).
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: MYC genetic alteration cell panel (ATCC TCP-1035).
CC   Part of: Seoul National University (SNU) cell line collection.
CC   Part of: TCGA-110-CL cell line panel.
CC   Population: Korean.
CC   Doubling time: 27 hours (ATCC; PubMed=2158397).
CC   HLA typing: A*33:03,24:02; B*55:01,52:01; C*01:02,01:02; DQB1*06:13,06:13; DRB1*13:02,13:02 (PubMed=25960936).
CC   Microsatellite instability: Stable (MSS) (PubMed=10674020; Sanger).
CC   Sequence variation: CD44-SLC1A2 gene fusion (PubMed=23637631).
CC   Sequence variation: Heterozygous for MSH6 p.Lys1358fs*2 (c.4065_4066insTTGA) (CCLE; Cosmic-CLP).
CC   Sequence variation: Homozygous for TP53 p.Tyr205Phe (c.614A>T) (PubMed=1676761; CCLE; Cosmic-CLP).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=3.14%; Native American=0.82%; East Asian, North=65.94%; East Asian, South=27.38%; South Asian=0%; European, North=0%; European, South=2.71% (PubMed=30894373).
CC   Derived from metastatic site: Ascites.
ST   Source(s): ATCC; Cosmic-CLP; KCLB; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8,12
ST   D16S539: 11,13
ST   D18S51: 14,16
ST   D21S11: 29,33.2
ST   D3S1358: 15,16
ST   D5S818: 10,13
ST   D7S820: 12
ST   D8S1179: 14
ST   FGA: 23
ST   Penta D: 9,12
ST   Penta E: 11,17
ST   TH01: 6,9
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C4004; Gastric adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   33Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 12-03-20; Version: 32
//
RX   DOI=10.1016/B978-0-12-333530-2.50014-9;
RA   Sekiguchi M., Suzuki T.;
RT   "Gastric tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York (1994).
//
RX   PubMed=1676761; DOI=10.1093/jnci/83.13.938;
RA   Kim J.-H., Takahashi T., Chiba I., Park J.-G., Birrer M.J., Roh J.K.,
RA   De Lee H., Kim J.-P., Minna J.D., Gazdar A.F.;
RT   "Occurrence of p53 gene abnormalities in gastric carcinoma tumors and
RT   cell lines.";
RL   J. Natl. Cancer Inst. 83:938-943(1991).
//
RX   PubMed=2158397;
RA   Park J.-G., Frucht H., La Rocca R.V., Bliss D.P. Jr., Kurita Y.,
RA   Chen T.-R., Henslee J.G., Trepel J.B., Jensen R.T., Johnson B.E.,
RA   Bang Y.-J., Kim J.-P., Gazdar A.F.;
RT   "Characteristics of cell lines established from human gastric
RT   carcinoma.";
RL   Cancer Res. 50:2773-2780(1990).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=8806095; DOI=10.1002/jcb.240630508;
RA   Park J.-G., Gazdar A.F.;
RT   "Biology of colorectal and gastric cancer cell lines.";
RL   J. Cell. Biochem. 63 Suppl. 24:131-141(1996).
//
RX   PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3;
RA   Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.;
RT   "Mutations in hMSH6 alone are not sufficient to cause the
RT   microsatellite instability in colorectal cancer cell lines.";
RL   Eur. J. Cancer 35:1724-1729(1999).
//
RX   PubMed=14720123; DOI=10.1042/BJ20031408;
RA   Kim H.-P., Lee M.-S., Yu J., Park J.-A., Jong H.-S., Kim T.-Y.,
RA   Lee J.W., Bang Y.-J.;
RT   "TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of
RT   gastric carcinoma cells involves a decrease in Ras/ERKs
RT   (extracellular-signal-regulated kinases) cascade activity dependent on
RT   c-Src activity.";
RL   Biochem. J. 379:141-150(2004).
//
RX   PubMed=19956504; DOI=10.4143/crt.2005.37.1.1;
RA   Ku J.-L., Park J.-G.;
RT   "Biology of SNU cell lines.";
RL   Cancer Res. Treat. 37:1-19(2005).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=23637631; DOI=10.1371/journal.pgen.1003464;
RA   Giacomini C.P., Sun S., Varma S., Shain A.H., Giacomini M.M.,
RA   Balagtas J., Sweeney R.T., Lai E., Del Vecchio C.A., Forster A.D.,
RA   Clarke N., Montgomery K.D., Zhu S., Wong A.J., van de Rijn M.,
RA   West R.B., Pollack J.R.;
RT   "Breakpoint analysis of transcriptional and genomic profiles uncovers
RT   novel gene fusions spanning multiple human cancer types.";
RL   PLoS Genet. 9:E1003464-E1003464(2013).
//
RX   PubMed=24807215; DOI=10.1038/ncomms4830;
RA   Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M.,
RA   Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H.,
RA   Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N.,
RA   Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D.,
RA   Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R.,
RA   Zhang Z.;
RT   "Integrated exome and transcriptome sequencing reveals ZAK isoform
RT   usage in gastric cancer.";
RL   Nat. Commun. 5:3830-3830(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H.,
RA   Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y.,
RA   Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D.,
RA   Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D.,
RA   Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S.,
RA   Zhang Z.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893;
RA   Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.;
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:E954893-E954893(2014).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P.,
RA   Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31395879; DOI=10.1038/s41467-019-11415-2;
RA   Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M.,
RA   van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.;
RT   "Comprehensive transcriptomic analysis of cell lines as models of
RT   primary tumors across 22 tumor types.";
RL   Nat. Commun. 10:3574-3574(2019).
//