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Cellosaurus SNU-5 (CVCL_0078)

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Cell line name SNU-5
Synonyms SNU5; NCI-SNU-5
Accession CVCL_0078
Resource Identification Initiative To cite this cell line use: SNU-5 (RRID:CVCL_0078)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Part of: MET genetic alteration cell panel (ATCC TCP-1036).
Part of: Seoul National University (SNU) cell line collection.
Doubling time: 34 hours (PubMed=2158397).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Gly262_Ser269delGlyAsnLeuLeuGlyArgAsnSer (c.784_807del24) (PubMed=1676761).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*26:01,24:02
HLA-BB*35:01,40:05
HLA-CC*03:03,03:03
Class II
HLA-DQDQA1*05:01,05:01
DQB1*03:09,03:09
HLA-DRDRB1*11:01,12:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North65.54
East Asian, South33.69
South Asian0
European, North0
European, South0.76
Disease Gastric carcinoma (NCIt: C4911)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; KCLB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D2S133817
D3S135816
D5S81810
D7S8208,12
D8S117914,15
D13S3178,9 (ATCC; Cosmic-CLP; PubMed=25877200)
8 (KCLB)
D16S53913
D18S5113
D19S43313.2,15
D21S1129
FGA21
Penta D9,13
Penta E18,19
TH019
TPOX11
vWA15,16

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
http://www.cellresource.cn/fdetail.aspx?id=1594
Publications

PubMed=2158397
Park J.-G., Frucht H., La Rocca R.V., Bliss D.P. Jr., Kurita Y., Chen T.-R., Henslee J.G., Trepel J.B., Jensen R.T., Johnson B.E., Bang Y.-J., Kim J.-P., Gazdar A.F.
Characteristics of cell lines established from human gastric carcinoma.
Cancer Res. 50:2773-2780(1990)

PubMed=1676761; DOI=10.1093/jnci/83.13.938
Kim J.-H., Takahashi T., Chiba I., Park J.-G., Birrer M.J., Roh J.K., De Lee H., Kim J.-P., Minna J.D., Gazdar A.F.
Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.
J. Natl. Cancer Inst. 83:938-943(1991)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=8806095; DOI=10.1002/jcb.240630508
Park J.-G., Gazdar A.F.
Biology of colorectal and gastric cancer cell lines.
J. Cell. Biochem. 63 Suppl. 24:131-141(1996)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H., Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830-3830(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CRL-5973
BCRC; 60213
KCLB; 00005
Cell line databases/resources CCLE; SNU5_STOMACH
CCRID; 3131C0001001200013
Cell_Model_Passport; SIDM01144
Cosmic-CLP; 908445
GDSC; 908445
IGRhCellID; SNU5
LINCS_LDP; LCL-1890
Ontologies BTO; BTO:0004986
CLO; CLO_0009102
EFO; EFO_0002351
MCCL; MCC:0000436
Biological sample resources BioSample; SAMN03470906
Chemistry resources ChEMBL-Cells; CHEMBL3307458
ChEMBL-Targets; CHEMBL614934
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM267422
GEO; GSM267429
GEO; GSM267436
GEO; GSM267443
GEO; GSM552374
GEO; GSM562408
GEO; GSM827398
GEO; GSM828830
GEO; GSM844703
GEO; GSM887634
GEO; GSM888720
GEO; GSM1237681
GEO; GSM1237706
GEO; GSM1374893
GEO; GSM1670275
GEO; GSM1670473
Other Wikidata; Q54955215
Polymorphism and mutation databases Cosmic; 685587
Cosmic; 687559
Cosmic; 737363
Cosmic; 848137
Cosmic; 868237
Cosmic; 908445
Cosmic; 921596
Cosmic; 1066231
Cosmic; 1067203
Cosmic; 1090451
Cosmic; 1154648
Cosmic; 1187293
Cosmic; 1294960
Cosmic; 1329187
Cosmic; 1482072
Cosmic; 1528872
Cosmic; 1995597
Cosmic; 2069773
Cosmic; 2373750
Cosmic; 2484972
Cosmic; 2646589
IARC_TP53; 307
IARC_TP53; 21582
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number28