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Cellosaurus NALM-1 (CVCL_0091)

[Text version]

Cell line name NALM-1
Synonyms Nalm-1; NALM 1; NALM1; Nalm1
Accession CVCL_0091
Resource Identification Initiative To cite this cell line use: NALM-1 (RRID:CVCL_0091)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~48 hours (DSMZ).
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Childhood chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C7320)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 3Y
Category Cancer cell line
STR profile Source(s): ATCC; DSMZ


Run an STR similarity search on this cell line

PubMed=301573; DOI=10.1093/jnci/59.1.83
Minowada J., Tsubota T., Greaves M.F., Walters T.R.
A non-T, non-B human leukemia cell line (NALM-1): establishment of the cell line and presence of leukemia-associated antigens.
J. Natl. Cancer Inst. 59:83-87(1977)

PubMed=302341; DOI=10.1093/jnci/59.3.833
Sonta S.-I., Minowada J., Tsubota T., Sandberg A.A.
Cytogenetic study of a new Ph1-positive cell line (NALM-1).
J. Natl. Cancer Inst. 59:833-837(1977)

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Keating A.
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Matsuo Y., Drexler H.G.
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12506034; DOI=10.1182/blood-2002-06-1770
Uno K., Inukai T., Kayagaki N., Goi K., Sato H., Nemoto A., Takahashi K., Kagami K., Yamaguchi N., Yagita H., Okumura K., Koyama-Okazaki T., Suzuki T., Sugita K., Nakazawa S.
TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells.
Blood 101:3658-3667(2003)

PubMed=15588857; DOI=10.1016/j.cancergencyto.2004.04.021
Pelz A.-F., Weilepp G., Wieacker P.F.
Re-analysis of the cell line NALM-1 karyotype by GTG-banding, spectral karyotyping, and whole chromosome painting.
Cancer Genet. Cytogenet. 156:59-61(2005)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

Cell line collections ATCC; CRL-1567
JCRB; JCRB0064 - Discontinued
Cell line databases/resources CLDB; cl3630
CGH-DB; 9216-4
Ontologies CLO; CLO_0007937
EFO; EFO_0002244
Biological sample resources BioSample; SAMN01821583
BioSample; SAMN01821650
BioSample; SAMN03471397
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887346
GEO; GSM888422
Other Wikidata; Q54907391
Polymorphism and mutation databases Cosmic; 787506
Cosmic; 801721
Cosmic; 908157
Cosmic; 999775
Cosmic; 1012105
Cosmic; 1026573
Cosmic; 1498418
Cosmic; 2491099