ID   RS4;11
AC   CVCL_0093
SY   RS4-11; RS4:11; RS 4;11; RS(4;11); RS411
DR   BTO; BTO:0004505
DR   CLO; CLO_0008883
DR   AddexBio; C0003012/4671
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1873
DR   BioSample; SAMN03471039
DR   BioSample; SAMN03473511
DR   BioSample; SAMN10987766
DR   CCLE; RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DR   Cell_Model_Passport; SIDM01086
DR   ChEMBL-Cells; CHEMBL3308247
DR   ChEMBL-Targets; CHEMBL2366159
DR   Cosmic; 683547
DR   Cosmic; 909703
DR   Cosmic; 1012116
DR   Cosmic; 1037737
DR   Cosmic; 1118469
DR   Cosmic; 1127267
DR   Cosmic; 1130250
DR   Cosmic; 1278782
DR   Cosmic; 1509199
DR   Cosmic; 1524818
DR   Cosmic; 1623639
DR   Cosmic; 2131570
DR   Cosmic; 2393009
DR   Cosmic; 2393010
DR   Cosmic; 2491091
DR   Cosmic; 2542840
DR   Cosmic-CLP; 909703
DR   DSMZ; ACC-508
DR   DepMap; ACH-000874
DR   GDSC; 909703
DR   GEO; GSM236803
DR   GEO; GSM236839
DR   GEO; GSM887550
DR   GEO; GSM888633
DR   GEO; GSM1374856
DR   GEO; GSM1670392
DR   LiGeA; CCLE_681
DR   LINCS_LDP; LCL-1040
DR   Lonza; 714
DR   PharmacoDB; RS4_11_1331_2019
DR   Progenetix; CVCL_0093
DR   Wikidata; Q54951304
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1423625;
RX   PubMed=1465024;
RX   PubMed=1720549;
RX   PubMed=3917311;
RX   PubMed=8180386;
RX   PubMed=8353274;
RX   PubMed=8358709;
RX   PubMed=9067587;
RX   PubMed=9738977;
RX   PubMed=14671638;
RX   PubMed=15843827;
RX   PubMed=16408098;
RX   PubMed=16523483;
RX   PubMed=20164919;
RX   PubMed=20922763;
RX   PubMed=21552520;
RX   PubMed=22460905;
RX   PubMed=25984343;
RX   PubMed=27397505;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=32721124;
WW   http://www.cogcell.org/cellreqs-ncipptp.php
WW   http://www.pptpinvitro.org/cell_lines_panel.php
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
CC   Doubling time: 35 hours (PubMed=20922763); 60 hours (PubMed=25984343); ~50 hours (DSMZ).
CC   Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
CC   Sequence variation: Gene fusion; HGNC; 7135; AFF1 + HGNC; 7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4; Note=In frame (PubMed=1423625; PubMed=8358709; PubMed=32721124).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative phosphoproteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0%; Native American=0.02%; East Asian, North=0%; East Asian, South=1.26%; South Asian=1.83%; European, North=65.49%; European, South=31.4% (PubMed=30894373).
CC   Misspelling: RS-E11; In Cosmic 2131570.
CC   Derived from sampling site: Bone marrow.
ST   Source(s): AddexBio; ATCC; COG; Cosmic-CLP; DSMZ; PubMed=20922763; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 12,16
ST   D19S433: 12,14
ST   D21S11: 28,30
ST   D2S1338: 20,25
ST   D3S1358: 15,17
ST   D5S818: 12 (DSMZ)
ST   D5S818: 12,13 (AddexBio; ATCC; COG; Cosmic-CLP; PubMed=20922763; PubMed=25877200)
ST   D7S820: 8,12
ST   D8S1179: 13,14
ST   FGA: 24,25
ST   Penta D: 8.4,10
ST   Penta E: 5,7
ST   TH01: 6,9.3
ST   TPOX: 8
ST   vWA: 14,17
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   NCIt; C80342; B acute lymphoblastic leukemia with t(v;11q23.3) KMT2A rearranged
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   32Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 35
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=1423625; DOI=10.1016/0092-8674(92)90603-A;
RA   Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G.,
RA   Croce C.M., Canaani E.;
RT   "The t(4;11) chromosome translocation of human acute leukemias fuses
RT   the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.";
RL   Cell 71:701-708(1992).
//
RX   PubMed=1465024; DOI=10.1016/0145-2126(92)90113-L;
RA   Iida S., Saito M., Okazaki T., Seto M., Yamamoto K., Akao Y.,
RA   Ogura M., Suzuki H., Ariyoshi Y., Koike K., Nitta M., Takahashi T.,
RA   Ueda R., Nakazawa S.;
RT   "Phenotypic and genotypic characterization of 14 leukemia and lymphoma
RT   cell lines with 11q23 translocations.";
RL   Leuk. Res. 16:1155-1163(1992).
//
RX   PubMed=1720549; DOI=10.1073/pnas.88.23.10735;
RA   Ziemin-van der Poel S., McCabe N.R., Gill H.J., Espinosa R. III,
RA   Patel Y., Harden A., Rubinelli P., Smith S.D., Le Beau M.M.,
RA   Rowley J.D., Diaz M.O.;
RT   "Identification of a gene, MLL, that spans the breakpoint in 11q23
RT   translocations associated with human leukemias.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10735-10739(1991).
//
RX   PubMed=3917311; DOI=10.1182/blood.V65.1.21.21;
RA   Stong R.C., Korsmeyer S.J., Parkin J.L., Arthur D.C., Kersey J.H.;
RT   "Human acute leukemia cell line with the t(4;11) chromosomal
RT   rearrangement exhibits B lineage and monocytic characteristics.";
RL   Blood 65:21-31(1985).
//
RX   PubMed=8180386; DOI=10.1182/blood.V83.10.2912.2912;
RA   Yamamoto K., Seto M., Iida S., Komatsu H., Kamada N., Kojima S.,
RA   Kodera Y., Nakazawa S., Saito H., Takahashi T., Ueda R.;
RT   "A reverse transcriptase-polymerase chain reaction detects
RT   heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities.";
RL   Blood 83:2912-2921(1994).
//
RX   PubMed=8353274; DOI=10.1182/blood.V82.4.1080.1080;
RA   Chen C.-S., Hilden J.M., Frestedt J., Domer P.H., Moore R.,
RA   Korsmeyer S.J., Kersey J.H.;
RT   "The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal
RT   tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute
RT   leukemia.";
RL   Blood 82:1080-1085(1993).
//
RX   PubMed=8358709;
RA   Hilden J.M., Chen C.-S., Moore R., Frestedt J., Kersey J.H.;
RT   "Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the
RT   polymerase chain reaction in t(4;11) acute leukemia.";
RL   Cancer Res. 53:3853-3866(1993).
//
RX   PubMed=9067587; DOI=10.1038/sj.leu.2400571;
RA   Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A.,
RA   Janssen J.W.G., Drexler H.G.;
RT   "Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in
RT   human early B-lineage leukemia cell lines.";
RL   Leukemia 11:441-447(1997).
//
RX   PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x;
RA   Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T.,
RA   Aizawa Y., Ueda R., Seto M.;
RT   "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not
RT   in adult T-cell leukemia.";
RL   Jpn. J. Cancer Res. 89:712-718(1998).
//
RX   PubMed=14671638; DOI=10.1038/sj.leu.2403236;
RA   Drexler H.G., Quentmeier H., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   MLL gene alterations.";
RL   Leukemia 18:227-232(2004).
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J.,
RA   Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M.,
RA   Fioretos T.;
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=16408098; DOI=10.1038/sj.leu.2404081;
RA   Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.;
RT   "JAK2 V617F tyrosine kinase mutation in cell lines derived from
RT   myeloproliferative disorders.";
RL   Leukemia 20:471-476(2006).
//
RX   PubMed=16523483; DOI=10.1002/gcc.20317;
RA   Horsley S.W., Mackay A., Iravani M., Fenwick K., Valgeirsson H.,
RA   Dexter T., Ashworth A., Kearney L.;
RT   "Array CGH of fusion gene-positive leukemia-derived cell lines reveals
RT   cryptic regions of genomic gain and loss.";
RL   Genes Chromosomes Cancer 45:554-564(2006).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20922763; DOI=10.1002/pbc.22801;
RA   Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J.,
RA   Reynolds C.P.;
RT   "National Cancer Institute pediatric preclinical testing program:
RT   model description for in vitro cytotoxicity testing.";
RL   Pediatr. Blood Cancer 56:239-249(2011).
//
RX   PubMed=21552520; DOI=10.1371/journal.pone.0019169;
RA   Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S.A.,
RA   Tucker M., Kornhauser J., Ren J., MacNeill J., Gygi S.P., Druker B.J.,
RA   Heinrich M.C., Rush J., Polakiewicz R.D.;
RT   "Survey of activated FLT3 signaling in leukemia.";
RL   PLoS ONE 6:E19169-E19169(2011).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.,
RA   Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404;
RA   Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.;
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:E0210404-E0210404(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=32721124; DOI=10.1002/cnr2.1207;
RA   Ragusa D., Makarov E.M., Britten O., Moralli D., Green C.M., Tosi S.;
RT   "The RS4;11 cell line as a model for leukaemia with t(4;11)(q21;q23):
RT   revised characterisation of cytogenetic features.";
RL   Cancer Rep. 2:e1207.1-e1207.11(2019).
//