Cell line name | SKM-1 | ||||||||||||||||||||||||||||||||
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Synonyms | SKM1 | ||||||||||||||||||||||||||||||||
Accession | CVCL_0098 | ||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: SKM-1 (RRID:CVCL_0098) | ||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Population: Japanese. Doubling time: ~48 hours (PubMed=8136267); ~48 hours (DSMZ). Microsatellite instability: Stable (MSS) (Sanger). Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. Caution: TP53 mutation indicated incorrectly as being at p.Tyr327His (c.981T>C) in PubMed=8136267. Derived from sampling site: Peripheral blood. | ||||||||||||||||||||||||||||||||
Sequence variations | Homozygous for ASXL1 p.Tyr591Ter (c.1773C>A) (ClinVar=VCV000451016) (PubMed=27750403).Homozygous for BCORL1 c.4619-1G>A (PubMed=21989985; PubMed=27750403; CCLE; Cosmic-CLP).Homozygous for KRAS p.Lys117Asn (c.351A>C) (ClinVar=VCV000375965) (CCLE; Cosmic-CLP).Homozygous for TP53 p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (PubMed=27750403; CCLE; Cosmic-CLP). | ||||||||||||||||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Adult acute myeloid leukemia (NCIt: C9154) Myelodysplastic syndrome (NCIt: C3247) Acute myeloid leukemia (ORDO: Orphanet_519) | ||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Sex of cell | Male | ||||||||||||||||||||||||||||||||
Age at sampling | 76Y | ||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||
STR profile | Source(s): Cosmic-CLP; DSMZ; JCRB; PubMed=25877200 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
Publications | PubMed=8136267; DOI=10.1111/j.1365-2141.1993.tb03334.x PubMed=8580805; DOI=10.3109/10428199509056841 DOI=10.1016/B978-0-12-221970-2.50457-5 PubMed=16408098; DOI=10.1038/sj.leu.2404081 PubMed=20164919; DOI=10.1038/nature08768 PubMed=21989985; DOI=10.1182/blood-2011-05-356204 PubMed=22460905; DOI=10.1038/nature11003 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=27750403; DOI=10.1002/gcc.22430 PubMed=30285677; DOI=10.1186/s12885-018-4840-5 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 | ||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||
Cell line collections | DSMZ; ACC-547
JCRB; JCRB0118 JCRB; NIHS0147 - Discontinued | ||||||||||||||||||||||||||||||||
Cell line databases/resources | CCLE; SKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00380 Cosmic-CLP; 909722 DepMap; ACH-000373 | ||||||||||||||||||||||||||||||||
Ontologies | EFO; EFO_0006753 | ||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03470798
BioSample; SAMN03473113 BioSample; SAMN10988125 | ||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308216
ChEMBL-Targets; CHEMBL2366085 GDSC; 909722 PharmacoDB; SKM1_1418_2019 | ||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-2706 ArrayExpress; E-MTAB-3610 GEO; GSM482513 GEO; GSM887581 GEO; GSM888664 GEO; GSM1374880 GEO; GSM1446741 GEO; GSM1670435 GEO; GSM2124121 | ||||||||||||||||||||||||||||||||
Other | Wikidata; Q54954746 | ||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 787477
Cosmic; 909722 Cosmic; 975300 Cosmic; 1012119 Cosmic; 1078731 Cosmic; 1465964 Cosmic; 1551462 Cosmic; 2131566 Cosmic; 2750855 IARC_TP53; 27238 LiGeA; CCLE_537 Progenetix; CVCL_0098 | ||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||
Last entry update | 29-Oct-2020 | ||||||||||||||||||||||||||||||||
Version number | 31 |