ID   SNU-1
AC   CVCL_0099
SY   SNU1; NCI-SNU-1
DR   BTO; BTO:0005786
DR   CLO; CLO_0009094
DR   EFO; EFO_0002343
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-5971
DR   BCRC; 60210
DR   BioSample; SAMN03472628
DR   BioSample; SAMN10988139
DR   CCLE; SNU1_STOMACH
DR   Cell_Model_Passport; SIDM01146
DR   ChEMBL-Cells; CHEMBL3307455
DR   ChEMBL-Targets; CHEMBL614931
DR   Cosmic; 685584
DR   Cosmic; 724854
DR   Cosmic; 737362
DR   Cosmic; 848136
DR   Cosmic; 887260
DR   Cosmic; 908444
DR   Cosmic; 921595
DR   Cosmic; 1090450
DR   Cosmic; 1154647
DR   Cosmic; 1187294
DR   Cosmic; 1294954
DR   Cosmic; 1528871
DR   Cosmic; 1995595
DR   Cosmic; 2069772
DR   Cosmic; 2373749
DR   Cosmic; 2484960
DR   Cosmic; 2646585
DR   Cosmic-CLP; 908444
DR   DepMap; ACH-000932
DR   GDSC; 908444
DR   GEO; GSM267421
DR   GEO; GSM267428
DR   GEO; GSM267435
DR   GEO; GSM267442
DR   GEO; GSM552372
DR   GEO; GSM562406
DR   GEO; GSM827406
DR   GEO; GSM844701
DR   GEO; GSM887614
DR   GEO; GSM888698
DR   GEO; GSM1237679
DR   GEO; GSM1237704
DR   GEO; GSM1374885
DR   GEO; GSM1670273
DR   GEO; GSM1670462
DR   IARC_TP53; 21581
DR   IARC_TP53; 30155
DR   IGRhCellID; SNU1
DR   KCLB; 00001
DR   LiGeA; CCLE_775
DR   LINCS_LDP; LCL-1888
DR   PharmacoDB; SNU1_1432_2019
DR   Wikidata; Q54955083
RX   DOI=10.1016/B978-0-12-333530-2.50014-9;
RX   PubMed=1676761;
RX   PubMed=2158397;
RX   PubMed=8806092;
RX   PubMed=8806095;
RX   PubMed=10674020;
RX   PubMed=12068308;
RX   PubMed=18804159;
RX   PubMed=19956504;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=24807215;
RX   PubMed=25485619;
RX   PubMed=25960936;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
WW   http://tcpaportal.org/mclp/
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: Seoul National University (SNU) cell line collection.
CC   Doubling time: 26 hours (ATCC; PubMed=2158397).
CC   HLA typing: A*02:07,30:04; B*14:01,51:01; C*08:05,01:02; DRB1*15:01,15:01 (PubMed=25960936).
CC   Microsatellite instability: Instable (MSI-high) (PubMed=10674020; PubMed=31068700; Sanger).
CC   Sequence variation: Heterozygous for ATM p.Leu1154fs*12 (c.3457_3458insT) (CCLE; Cosmic-CLP).
CC   Sequence variation: Heterozygous for JAK1 p.Lys860fs*16 (c.2580delA) (CCLE; Cosmic-CLP).
CC   Sequence variation: Heterozygous for KRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000012582) (PubMed=12068308; CCLE).
CC   Sequence variation: Has no TP53 mutation (PubMed=1676761).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0%; Native American=0.88%; East Asian, North=57.18%; East Asian, South=41.93%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
ST   Source(s): ATCC; Cosmic-CLP; KCLB
ST   Amelogenin: X,Y
ST   CSF1PO: 12,13 (ATCC; Cosmic-CLP)
ST   CSF1PO: 12,14 (KCLB)
ST   D13S317: 11,14 (ATCC; Cosmic-CLP)
ST   D13S317: 12,14 (KCLB)
ST   D16S539: 9,12
ST   D3S1358: 16,17
ST   D5S818: 12,13 (ATCC; Cosmic-CLP)
ST   D5S818: 13 (KCLB)
ST   D7S820: 9,12
ST   FGA: 22
ST   TH01: 8,9.3
ST   TPOX: 8,10
ST   vWA: 14
DI   NCIt; C4004; Gastric adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   44Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-07-20; Version: 33
//
RX   DOI=10.1016/B978-0-12-333530-2.50014-9;
RA   Sekiguchi M., Suzuki T.;
RT   "Gastric tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York (1994).
//
RX   PubMed=1676761; DOI=10.1093/jnci/83.13.938;
RA   Kim J.-H., Takahashi T., Chiba I., Park J.-G., Birrer M.J., Roh J.K.,
RA   De Lee H., Kim J.-P., Minna J.D., Gazdar A.F.;
RT   "Occurrence of p53 gene abnormalities in gastric carcinoma tumors and
RT   cell lines.";
RL   J. Natl. Cancer Inst. 83:938-943(1991).
//
RX   PubMed=2158397;
RA   Park J.-G., Frucht H., La Rocca R.V., Bliss D.P. Jr., Kurita Y.,
RA   Chen T.-R., Henslee J.G., Trepel J.B., Jensen R.T., Johnson B.E.,
RA   Bang Y.-J., Kim J.-P., Gazdar A.F.;
RT   "Characteristics of cell lines established from human gastric
RT   carcinoma.";
RL   Cancer Res. 50:2773-2780(1990).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=8806095; DOI=10.1002/jcb.240630508;
RA   Park J.-G., Gazdar A.F.;
RT   "Biology of colorectal and gastric cancer cell lines.";
RL   J. Cell. Biochem. 63 Suppl. 24:131-141(1996).
//
RX   PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3;
RA   Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.;
RT   "Mutations in hMSH6 alone are not sufficient to cause the
RT   microsatellite instability in colorectal cancer cell lines.";
RL   Eur. J. Cancer 35:1724-1729(1999).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=18804159; DOI=10.1016/j.ygeno.2008.08.002;
RA   Jung J.-J., Jeung H.-C., Chung H.C., Lee J.O., Kim T.S., Kim Y.T.,
RA   Noh S.H., Rha S.Y.;
RT   "In vitro pharmacogenomic database and chemosensitivity predictive
RT   genes in gastric cancer.";
RL   Genomics 93:52-61(2009).
//
RX   PubMed=19956504; DOI=10.4143/crt.2005.37.1.1;
RA   Ku J.-L., Park J.-G.;
RT   "Biology of SNU cell lines.";
RL   Cancer Res. Treat. 37:1-19(2005).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=24807215; DOI=10.1038/ncomms4830;
RA   Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M.,
RA   Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H.,
RA   Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N.,
RA   Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D.,
RA   Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R.,
RA   Zhang Z.;
RT   "Integrated exome and transcriptome sequencing reveals ZAK isoform
RT   usage in gastric cancer.";
RL   Nat. Commun. 5:3830-3830(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H.,
RA   Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y.,
RA   Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D.,
RA   Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D.,
RA   Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S.,
RA   Zhang Z.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893;
RA   Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.;
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:E954893-E954893(2014).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P.,
RA   Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023;
RA   Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III,
RA   Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K.,
RA   Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K.,
RA   Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A.,
RA   Sellers W.R., Gygi S.P.;
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//