Cellosaurus UKE-1 (CVCL_0104)

Cell line name UKE-1
Synonyms UKE1; GM23245
Accession CVCL_0104
Resource Identification Initiative To cite this cell line use: UKE-1 (RRID:CVCL_0104)
Comments Characteristics: Patient had a essential thrombocythemia transformed into acute leukemia.
Sequence variation: Homozygous for JAK2 p.Val617Phe (PubMed=16408098).
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Essential thrombocythemia (NCIt: C3407)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_4Z62 (UKE-1/TGR)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=10640966; DOI=10.1002/(SICI)1097-0142(20000115)88:2<344::AID-CNCR14>3.0.CO;2-6
Fiedler W., Henke R.P., Ergun S., Schumacher U., Gehling U.M., Vohwinkel G., Kilic N., Hossfeld D.K.
Derivation of a new hematopoietic cell line with endothelial features from a patient with transformed myeloproliferative syndrome: a case report.
Cancer 88:344-351(2000)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22829968; DOI=10.1038/bcj.2012.11
Buors C., Douet-Guilbert N., Morel F., Lecucq L., Cassinat B., Ugo V.
Clonal evolution in UKE-1 cell line leading to an increase in JAK2 copy number.
Blood Cancer J. 2:E66-E66(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections Coriell; GM23245
Ontologies BTO; BTO:0004765
EFO; EFO_0006307
Gene expression databases GEO; GSM1374976
Polymorphism and mutation databases Cosmic; 1012055
Cosmic; 1281361
Cosmic; 1519161
Cosmic; 1633514
Cosmic; 2306996