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Cellosaurus UKE-1 (CVCL_0104)

[Text version]

Cell line name UKE-1
Synonyms UKE1; GM23245
Accession CVCL_0104
Resource Identification Initiative To cite this cell line use: UKE-1 (RRID:CVCL_0104)
Comments Characteristics: Patient had a essential thrombocythemia transformed into acute leukemia.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Homozygous for JAK2 p.Val617Phe (c.1849G>T) (ClinVar=VCV000014662) (PubMed=16408098).
Disease Essential thrombocythemia (NCIt: C3407)
Essential thrombocythemia (ORDO: Orphanet_3318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line

PubMed=10640966; DOI=10.1002/(SICI)1097-0142(20000115)88:2<344::AID-CNCR14>3.0.CO;2-6
Fiedler W., Henke R.P., Ergun S., Schumacher U., Gehling U.M., Vohwinkel G., Kilic N., Hossfeld D.K.
Derivation of a new hematopoietic cell line with endothelial features from a patient with transformed myeloproliferative syndrome: a case report.
Cancer 88:344-351(2000)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22829968; DOI=10.1038/bcj.2012.11
Buors C., Douet-Guilbert N., Morel F., Lecucq L., Cassinat B., Ugo V.
Clonal evolution in UKE-1 cell line leading to an increase in JAK2 copy number.
Blood Cancer J. 2:E66-E66(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cell line collections Coriell; GM23245
Ontologies BTO; BTO:0004765
EFO; EFO_0006307
Chemistry resources PharmacoDB; UKE1_1641_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM1374976
Other Wikidata; Q54990275
Polymorphism and mutation databases Cosmic; 1012055
Cosmic; 1281361
Cosmic; 1519161
Cosmic; 1633514
Cosmic; 2306996
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number19