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Cellosaurus 1321N1 (CVCL_0110)

[Text version]

Cell line name 1321N1
Synonyms 1321-N1; 1321 N1
Accession CVCL_0110
Resource Identification Initiative To cite this cell line use: 1321N1 (RRID:CVCL_0110)
Comments Problematic cell line: Contaminated. Grand-parent cell line (U-118MG) has been shown to be a U-138MG derivative.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Brain.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North1.62
East Asian, South0
South Asian0
European, North96.5
European, South0.81
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D317 (1181N1)
CVCL_5I82 (1321N1 (+Galpha16) AequoScreen )CVCL_5I83 (1321N1 AequoScreen )CVCL_KU48 (1321N1 P2RY1 Gq )
CVCL_ZD90 (1321N1-HA-P2Y1 )CVCL_ZD94 (1321N1-HA-P2Y11 )CVCL_ZD95 (1321N1-HA-P2Y12 )
CVCL_ZD96 (1321N1-HA-P2Y13 )CVCL_ZD97 (1321N1-HA-P2Y14 )CVCL_ZD91 (1321N1-HA-P2Y2 )
CVCL_ZD92 (1321N1-HA-P2Y4 )CVCL_ZD93 (1321N1-HA-P2Y6 )CVCL_KT02 (1321N1/FFAR1 )
CVCL_H355 (1321N1/P2Y1 )CVCL_H356 (1321N1/P2Y11 )CVCL_H357 (1321N1/P2Y12/Galpha15 )
CVCL_H358 (1321N1/P2Y2 )CVCL_H359 (1321N1/P2Y4 )CVCL_H360 (1321N1/P2Y6 )
CVCL_KU71 (cAMP Hunter 1321N1 CALCR-RAMP3 Gs )
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=17254797; PubMed=25877200

CSF1PO11 (PubMed=17254797)
11,12 (ECACC; PubMed=25877200)
D21S1127 (PubMed=17254797)
27,32.2 (PubMed=25877200)
Penta D10,13
Penta E7

Run an STR similarity search on this cell line
Web pages https://www.phe-culturecollections.org.uk/media/125051/1321n1-cell-line-profile.pdf

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Tehrani M.J., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections ECACC; 86030402
NCBI_Iran; C118
Cell line databases/resources CLO; CLO_0001072
MCCL; MCC:0000001
CLDB; cl5
Cell_Model_Passport; SIDM01967
DepMap; ACH-001000
Anatomy/cell type resources BTO; BTO:0003605
Biological sample resources BioSample; SAMN03471026
Chemistry resources PharmacoDB; 1321N1_2_2019
Encyclopedic resources Wikidata; Q54581478
Gene expression databases GEO; GSM827421
GEO; GSM886835
GEO; GSM887898
GEO; GSM1374373
Polymorphism and mutation databases IARC_TP53; 21148
Progenetix; CVCL_0110
Entry history
Entry creation04-Apr-2012
Last entry update17-Mar-2022
Version number28