ID   1321N1
AC   CVCL_0110
SY   1321-N1; 1321 N1
DR   BTO; BTO:0003605
DR   CLO; CLO_0001072
DR   MCCL; MCC:0000001
DR   CLDB; cl5
DR   BioSample; SAMN03471026
DR   cancercelllines; CVCL_0110
DR   Cell_Model_Passport; SIDM01967
DR   DepMap; ACH-001000
DR   ECACC; 86030402
DR   GEO; GSM827421
DR   GEO; GSM886835
DR   GEO; GSM887898
DR   GEO; GSM1374373
DR   GEO; GSM3034453
DR   GEO; GSM3034454
DR   GEO; GSM3034455
DR   GEO; GSM3034456
DR   GEO; GSM3034457
DR   GEO; GSM3034458
DR   IARC_TP53; 21148
DR   IZSLER; BS TCL 109
DR   LINCS_LDP; LCL-1393
DR   NCBI_Iran; C118
DR   PharmacoDB; 1321N1_2_2019
DR   Progenetix; CVCL_0110
DR   Wikidata; Q54581478
RX   PubMed=17254797;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=25877200;
RX   PubMed=29887596;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   https://www.phe-culturecollections.org.uk/media/125051/1321n1-cell-line-profile.pdf
CC   Problematic cell line: Contaminated. Grand-parent cell line (U-118MG) has been shown to be a U-138MG derivative.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=1.06%; Native American=0%; East Asian, North=1.62%; East Asian, South=0%; South Asian=0%; European, North=96.5%; European, South=0.81% (PubMed=30894373).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
ST   Source(s): ECACC; IZSLER; PubMed=17254797; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 11 (PubMed=17254797)
ST   CSF1PO: 11,12 (ECACC; IZSLER; PubMed=25877200)
ST   D13S317: 9,11
ST   D16S539: 12,13
ST   D18S51: 13,14
ST   D19S433: 13
ST   D21S11: 27 (PubMed=17254797)
ST   D21S11: 27,32.2 (IZSLER; PubMed=25877200)
ST   D2S1338: 23,25
ST   D3S1358: 15
ST   D5S818: 11
ST   D7S820: 9
ST   D8S1179: 14,15
ST   FGA: 18,23,24
ST   Penta D: 10,13
ST   Penta E: 7
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_D317 ! 1181N1
SX   Male
AG   47Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 32
//
RX   PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001;
RA   Azari S., Ahmadi N., Tehrani M.J., Shokri F.;
RT   "Profiling and authentication of human cell lines using short tandem
RT   repeat (STR) loci: report from the National Cell Bank of Iran.";
RL   Biologicals 35:195-202(2007).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=29887596; DOI=10.1038/s41388-018-0301-5;
RA   Yu O.M., Benitez J.A., Plouffe S.W., Ryback D., Klein A., Smith J.,
RA   Greenbaum J., Delatte B., Rao A., Guan K.-L., Furnari F.B., Chaim O.M.,
RA   Miyamoto S., Brown J.H.;
RT   "YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene
RT   expression, are critical for glioblastoma tumorigenicity.";
RL   Oncogene 37:5492-5507(2018).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//