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Cellosaurus 4T1 (CVCL_0125)

[Text version]

Cell line name 4T1
Synonyms 4T1-A; 4T1.0; 4T1/WT
Accession CVCL_0125
Resource Identification Initiative To cite this cell line use: 4T1 (RRID:CVCL_0125)
Comments Characteristics: Metastatic.
Doubling time: 12.6 hours (ATCC).
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Omics: Transcriptome analysis.
Derived from sampling site: Mammary gland.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/cfC3H.
Hierarchy Parent: CVCL_W343 (410.4)
Children:
CVCL_QZ56 (4T1-eGFP-Puro )CVCL_QZ57 (4T1-Fluc-Neo )CVCL_QZ58 (4T1-Fluc-Neo/eGFP-Puro )
CVCL_QZ59 (4T1-Fluc-Neo/iRFP-Puro )CVCL_QZ60 (4T1-iRFP-Puro )CVCL_J239 (4T1-Luc )
CVCL_A4BM (4T1-Luc2 [ATCC] )CVCL_L899 (4T1-luc2 [Caliper] )CVCL_5J28 (4T1-luc2-GFP )
CVCL_5J46 (4T1-luc2-tdTomato )CVCL_QZ61 (4T1-mNIS (monoclonal) )CVCL_QZ62 (4T1-mNIS-Neo/eGFP-Puro )
CVCL_QZ63 (4T1-mNIS-Neo/iRFP-Puro )CVCL_QZ64 (4T1-mNIS-Puro )CVCL_QZ65 (4T1-mNIS-Puro/Fluc-Neo )
CVCL_5I84 (4T1-Red-FLuc )CVCL_5I85 (4T1-Red-FLuc-GFP )CVCL_HE47 (4T1-S )
CVCL_5J45 (4T1-tdTomato )CVCL_GR31 (4T1.13 )CVCL_GR32 (4T1.2 )
CVCL_B3QZ (4T1.3 )CVCL_JG34 (4T1/CMV-Luc #6 )CVCL_C0U6 (4T1/EPB )
CVCL_XG69 (4T1/GFP/FlucII )
Sex of cell Female
Category Cancer cell line
STR profile Source(s): PubMed=31220119

Markers:
Mouse STR 1-115,16
Mouse STR 1-217
Mouse STR 2-116,17
Mouse STR 3-214,15
Mouse STR 4-221.3
Mouse STR 5-514
Mouse STR 6-418
Mouse STR 6-712
Mouse STR 7-125.2
Mouse STR 8-113
Mouse STR 11-218,19,20
Mouse STR 12-116
Mouse STR 13-116.2
Mouse STR 15-322.3
Mouse STR 17-215
Mouse STR 18-318,19
Mouse STR 19-213
Mouse STR X-125

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/4T1
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/4/cell-lines-detail-66.html
Publications

PubMed=10411109; DOI=10.1023/A:1006689719505
Lelekakis M., Moseley J.M., Martin T.J., Hards D., Williams E., Ho P., Lowen D., Javni J., Miller F.R., Slavin J., Anderson R.L.
A novel orthotopic model of breast cancer metastasis to bone.
Clin. Exp. Metastasis 17:163-170(1999)

PubMed=26857856; DOI=10.1007/s13577-015-0127-1
Abe H., Wada H., Baghdadi M., Nakanishi S., Usui Y., Tsuchikawa T., Shichinohe T., Hirano S., Seino K.-I.
Identification of a highly immunogenic mouse breast cancer sub cell line, 4T1-S.
Hum. Cell 29:58-66(2016)

PubMed=27177471; DOI=10.1016/j.canlet.2016.05.005
Sasaki S.-I., Baba T., Nishimura T., Hayakawa Y., Hashimoto S.-I., Gotoh N., Mukaida N.
Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis.
Cancer Lett. 378:23-32(2016)

PubMed=31220119; DOI=10.1371/journal.pone.0218412
Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S., Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H., Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B., Natoli M., Bauer B., Gollin S.M., Lewis D.W., Reid Y.A.
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:E0218412-E0218412(2019)

Cross-references
Cell line collections AddexBio; C0006004/13
ATCC; CRL-2539
BCRJ; 0022
CCTCC; GDC0294
KCB; KCB 200967YJ
NCBI_Iran; C604
Cell line databases/resources CLO; CLO_0001401
MCCL; MCC:0000017
CCRID; 3101MOUSCSP5056
CCRID; 3101MOUTCM32
CCRID; 4201MOU-CCTCC00294
CCRID; 6101MOU-CERC000107
Lonza; 481
Anatomy/cell type resources BTO; BTO:0004311
Biological sample resources BioSample; SAMN11397647
Chemistry resources ChEMBL-Cells; CHEMBL3307995
ChEMBL-Targets; CHEMBL612589
Encyclopedic resources Wikidata; Q42802273
Experimental variables resources EFO; EFO_0002037
Gene expression databases GEO; GSM1529765
GEO; GSM1529766
GEO; GSM1529767
GEO; GSM1847461
GEO; GSM1847462
Proteomic databases PRIDE; PXD013948
PRIDE; PXD016112
PRIDE; PXD021413
PRIDE; PXD024762
PRIDE; PXD027822
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number26