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Cellosaurus 4T1 (CVCL_0125)

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Cell line name 4T1
Synonyms 4T1-A
Accession CVCL_0125
Resource Identification Initiative To cite this cell line use: 4T1 (RRID:CVCL_0125)
Comments Characteristics: Metastatic.
Doubling time: 12.6 hours (ATCC).
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Omics: Transcriptome analysis.
Derived from sampling site: Mammary gland.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/cfC3H.
Hierarchy Parent: CVCL_W343 (410.4)
Children:
CVCL_QZ56 (4T1-eGFP-Puro)CVCL_QZ57 (4T1-Fluc-Neo)CVCL_QZ58 (4T1-Fluc-Neo/eGFP-Puro)
CVCL_QZ59 (4T1-Fluc-Neo/iRFP-Puro)CVCL_QZ60 (4T1-iRFP-Puro)CVCL_J239 (4T1-Luc)
CVCL_A4BM (4T1-Luc2 [ATCC])CVCL_L899 (4T1-luc2 [Caliper])CVCL_5J28 (4T1-luc2-GFP)
CVCL_5J46 (4T1-luc2-tdTomato)CVCL_QZ61 (4T1-mNIS (monoclonal))CVCL_QZ62 (4T1-mNIS-Neo/eGFP-Puro)
CVCL_QZ63 (4T1-mNIS-Neo/iRFP-Puro)CVCL_QZ64 (4T1-mNIS-Puro)CVCL_QZ65 (4T1-mNIS-Puro/Fluc-Neo)
CVCL_5I84 (4T1-Red-FLuc)CVCL_5I85 (4T1-Red-FLuc-GFP)CVCL_HE47 (4T1-S)
CVCL_5J45 (4T1-tdTomato)CVCL_GR31 (4T1.13)CVCL_GR32 (4T1.2)
CVCL_JG34 (4T1/CMV-Luc #6)CVCL_XG69 (4T1/GFP/FlucII)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): PubMed=31220119

Markers:
Mouse STR 1-115,16
Mouse STR 1-217
Mouse STR 2-116,17
Mouse STR 3-214,15
Mouse STR 4-221.3
Mouse STR 5-514
Mouse STR 6-418
Mouse STR 6-712
Mouse STR 7-125.2
Mouse STR 8-113
Mouse STR 11-218,19,20
Mouse STR 12-116
Mouse STR 13-116.2
Mouse STR 15-322.3
Mouse STR 17-215
Mouse STR 18-318,19
Mouse STR 19-213
Mouse STR X-125

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/4T1
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/4/cell-lines-detail-66.html
Publications

PubMed=10411109; DOI=10.1023/A:1006689719505
Lelekakis M., Moseley J.M., Martin T.J., Hards D., Williams E., Ho P., Lowen D., Javni J., Miller F.R., Slavin J., Anderson R.L.
A novel orthotopic model of breast cancer metastasis to bone.
Clin. Exp. Metastasis 17:163-170(1999)

PubMed=26857856; DOI=10.1007/s13577-015-0127-1
Abe H., Wada H., Baghdadi M., Nakanishi S., Usui Y., Tsuchikawa T., Shichinohe T., Hirano S., Seino K.-I.
Identification of a highly immunogenic mouse breast cancer sub cell line, 4T1-S.
Hum. Cell 29:58-66(2016)

PubMed=31220119; DOI=10.1371/journal.pone.0218412
Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S., Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H., Li J., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B., Natoli M., Bauer B., Gollin S.M., Lewis D.W., Reid Y.A.
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:E0218412-E0218412(2019)

Cross-references
Cell line collections AddexBio; C0006004/13
ATCC; CRL-2539
BCRJ; 0022
CCTCC; GDC0294
KCB; KCB 200967YJ
NCBI_Iran; C604
Cell line databases/resources CCRID; 3131C0001000800032
CCRID; 3142C0001000000320
Lonza; 481
Ontologies BTO; BTO:0004311
CLO; CLO_0001401
EFO; EFO_0002037
MCCL; MCC:0000017
Biological sample resources BioSample; SAMN11397647
Chemistry resources ChEMBL-Cells; CHEMBL3307995
ChEMBL-Targets; CHEMBL612589
Gene expression databases GEO; GSM1529765
GEO; GSM1529766
GEO; GSM1529767
GEO; GSM1847461
GEO; GSM1847462
Other Wikidata; Q42802273
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number23