Cellosaurus A2780/CP70 (CVCL_0135)

Cell line name A2780/CP70
Synonyms A2780/CP; A2780-CP; A2780-cp; A 2780 CP; A2780CP; 2780CP; A2780CP70; CP70; CP-70
Accession CVCL_0135
Resource Identification Initiative To cite this cell line use: A2780/CP70 (RRID:CVCL_0135)
Comments Part of: MD Anderson Cell Lines Project.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Omics: Deep proteome analysis.
Omics: N-glycan profiling by lectin array.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): PubMed=17254797

Markers:
AmelogeninX
CSF1PO11
D13S31713
D16S53911,13
D18S5116,18
D21S1127,28
D3S135814,16
D5S81811,12
D7S8209,10
D8S117915,17
FGA19,24
TH016
TPOX8,10
vWA15,16
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=1999494; DOI=10.1172/JCI115080
Parker R.J., Eastman A., Bostick-Bruton F., Reed E.
Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.
J. Clin. Invest. 87:772-777(1991)

PubMed=7954422
Johnson S.W., Swiggard P.A., Handel L.M., Brennan J.M., Godwin A.K., Ozols R.F., Hamilton T.C.
Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells.
Cancer Res. 54:5911-5916(1994)

PubMed=12080474; DOI=10.1038/sj.onc.1205542
Manzano R.G., Montuenga L.M., Dayton M., Dent P., Kinoshita I., Vicent S., Gardner G.J., Nguyen P., Choi Y.H., Trepel J., Auersperg N., Birrer M.J.
CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential.
Oncogene 21:4435-4447(2002)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Tehrani M.J., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=27561551; DOI=10.1038/ncomms12645
Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.Y., Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Nat. Commun. 7:12645-12645(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28546799; DOI=10.1186/s12014-017-9155-z
Zhao R., Qin W.-J., Qin R.-H., Han J., Li C., Wang Y.-S., Xu C.-J.
Lectin array and glycogene expression analyses of ovarian cancer cell line A2780 and its cisplatin-resistant derivate cell line A2780-cp.
Clin. Proteomics 14:20-20(2017)

Cross-references
Cell line collections NCBI_Iran; C454
Ontologies BTO; BTO:0003845
BTO; BTO:0005766
MCCL; MCC:0000028
Gene expression databases GEO; GSM184400
GEO; GSM184401
GEO; GSM851908