Cellosaurus AGS (CVCL_0139)

Cell line name AGS
Accession CVCL_0139
Resource Identification Initiative To cite this cell line use: AGS (RRID:CVCL_0139)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: FGFR genetic alteration cell panel (ATCC TCP-1034).
Part of: JFCR45 cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: PI3K genetic alteration cell panel (ATCC TCP-1028).
Doubling time: 22 hours (PubMed=25984343).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_Y085 (AGS/EPI)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; CLS; Cosmic-CLP; ECACC; KCLB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D13S31712
D16S53911,13 (AddexBio; ATCC; CLS; Cosmic-CLP; ECACC)
11,12,13 (PubMed=25877200)
D18S5113 (CLS)
13,15 (PubMed=25877200)
D19S43313.2,14,15,16
D21S1129 (CLS)
27,29,31.2 (PubMed=25877200)
D2S133818,20,22,23
D3S135816 (CLS; PubMed=25877200)
15.2 (KCLB)
D5S8189,12 (AddexBio; ATCC; CLS; Cosmic-CLP; ECACC; KCLB)
9,12,13 (PubMed=25877200)
D7S82010,11 (AddexBio; ATCC; CLS; Cosmic-CLP; ECACC; KCLB)
10,11,13 (PubMed=25877200)
D8S117913 (CLS)
11,12,13 (PubMed=25877200)
FGA23,24 (CLS; KCLB)
20,23 (PubMed=25877200)
Penta D9,10 (CLS)
9,10,11,12 (PubMed=25877200)
Penta E13,16 (CLS)
11,12,13,16 (PubMed=25877200)
TH016,7 (AddexBio; ATCC; CLS; Cosmic-CLP; ECACC; KCLB)
7,9.3 (PubMed=25877200)
TPOX11,12 (AddexBio; ATCC; CLS; Cosmic-CLP; ECACC; KCLB)
8,11,12 (PubMed=25877200)
vWA16,17 (AddexBio; ATCC; CLS; Cosmic-CLP; ECACC; KCLB)
15,16,17 (PubMed=25877200)
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=10402490; DOI=10.3892/ijmm.4.2.203
Rha S.Y., Noh S.H., Kim T.S., Yoo N.-C., Roh J.-K., Min J.-S., Kim B.-S.
Modulation of biological phenotypes for tumor growth and metastasis by target-specific biological inhibitors in gastric cancer.
Int. J. Mol. Med. 4:203-212(1999)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=18804159; DOI=10.1016/j.ygeno.2008.08.002
Jung J.-J., Jeung H.-C., Chung H.C., Lee J.O., Kim T.S., Kim Y.T., Noh S.H., Rha S.Y.
In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer.
Genomics 93:52-61(2009)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H., Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830-3830(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections AddexBio; C0023004/4958
ATCC; CRL-1739
BCRC; 60102
BCRJ; 0311
CLS; 300408/p608_AGS
ECACC; 89090402
IZSLER; BS TCL 135
KCB; KCB 200708YJ
KCLB; 21739
NCBI_Iran; C131
Cell line databases/resources CLDB; cl258
CLDB; cl5134
CCLE; AGS_STOMACH
CCRID; 3131C0001000700007
Cosmic-CLP; 906790
GDSC; 906790
IGRhCellID; AGS
LINCS_HMS; 50004
LINCS_LDP; LCL-1893
Lonza; 727
TOKU-E; 522
Ontologies BTO; BTO:0001007
CLO; CLO_0001686
EFO; EFO_0002109
MCCL; MCC:0000032
Biological sample resources BioSample; SAMN03471028
BioSample; SAMN03471416
Chemistry resources ChEMBL-Cells; CHEMBL3308078
ChEMBL-Targets; CHEMBL613860
Gene expression databases GEO; GSM267417
GEO; GSM267424
GEO; GSM267431
GEO; GSM267438
GEO; GSM562392
GEO; GSM618009
GEO; GSM618010
GEO; GSM618011
GEO; GSM618012
GEO; GSM827400
GEO; GSM828792
GEO; GSM843440
GEO; GSM886864
GEO; GSM887929
GEO; GSM1237672
GEO; GSM1237697
GEO; GSM1374389
GEO; GSM1374390
GEO; GSM1669595
Polymorphism and mutation databases Cosmic; 685586
Cosmic; 848149
Cosmic; 868235
Cosmic; 873708
Cosmic; 887255
Cosmic; 888819
Cosmic; 906790
Cosmic; 1067211
Cosmic; 1090463
Cosmic; 1187266
Cosmic; 1294957
Cosmic; 1482073
Cosmic; 1518239
Cosmic; 1582429
Cosmic; 1627261
Cosmic; 1995340
Cosmic; 2036659
Cosmic; 2069770
Cosmic; 2484954
Proteomic databases PRIDE; PXD000722