Cell line name | AGS | ||||||||||||||||||||||||||||||||||||
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Accession | CVCL_0139 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: AGS (RRID:CVCL_0139) | ||||||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: FGFR genetic alteration cell panel (ATCC TCP-1034). Part of: JFCR45 cancer cell line panel. Part of: MD Anderson Cell Lines Project. Part of: PI3K genetic alteration cell panel (ATCC TCP-1028). Population: Caucasian. Characteristics: Persistently infected with parainfluenza virus type 5 (PIV5) strain PIV5-AGS (PubMed=17509637; PubMed=27445371). Doubling time: 24 hours (PubMed=1370612); 22 hours (PubMed=25984343); 20 hours (ATCC). Microsatellite instability: Stable (MSS) (Sanger). Omics: ChIP-seq GATA4 analysis. Omics: ChIP-seq GATA6 analysis. Omics: ChIP-seq KLF5 analysis. Omics: Deep exome analysis. Omics: Deep quantitative proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: shRNA library screening. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Stomach. | ||||||||||||||||||||||||||||||||||||
Sequence variations | Heterozygous for CTNNB1 p.Gly34Glu (c.101G>A) (ClinVar=VCV000017584) (ATCC; CCLE; Cosmic-CLP).Heterozygous for KRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000012582) (CCLE; Cosmic-CLP).Heterozygous for PIK3CA p.Glu453Lys (c.1357G>A) (ClinVar=VCV000376470) (CCLE; Cosmic-CLP).Heterozygous for PIK3CA p.Glu545Ala (c.1634A>C) (ClinVar=VCV000013659) (CCLE; Cosmic-CLP).Mutation; TP53; none detected (PubMed=1370612). | ||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=25960936
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Genome ancestry | Source: PubMed=30894373
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Disease | Gastric adenocarcinoma (NCIt: C4004) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Sex of cell | Female | ||||||||||||||||||||||||||||||||||||
Age at sampling | 54Y | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio; ATCC; BCRC; CCRID; CLS; Cosmic-CLP; ECACC; KCLB Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | http://tcpaportal.org/mclp/ http://www.cellresource.cn/fdetail.aspx?id=578 http://www.cellresource.cn/fdetail.aspx?id=2153 http://www.cellresource.cn/fdetail.aspx?id=3300 | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=6831414 PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0 DOI=10.1016/B978-0-12-333530-2.50014-9 PubMed=10402490; DOI=10.3892/ijmm.4.2.203 PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234 PubMed=17509637; DOI=10.1016/j.virol.2007.03.061 PubMed=18804159; DOI=10.1016/j.ygeno.2008.08.002 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=22460905; DOI=10.1038/nature11003 PubMed=24807215; DOI=10.1038/ncomms4830 PubMed=25960936; DOI=10.4161/21624011.2014.954893 PubMed=25984343; DOI=10.1038/sdata.2014.35 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=27445371; DOI=10.1128/genomeA.00653-16 PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 PubMed=29717028; DOI=10.1042/BSR20180277 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 PubMed=31978347; DOI=10.1016/j.cell.2019.12.023 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections | AddexBio; C0023004/4958
ATCC; CRL-1739 BCRC; 60102 BCRJ; 0311 CCTCC; GDC0247 CLS; 300408/p608_AGS ECACC; 89090402 IBRC; C10071 IZSLER; BS TCL 135 KCB; KCB 200708YJ KCLB; 21739 NCBI_Iran; C131 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl258
CLDB; cl5134 CCLE; AGS_STOMACH CCRID; 3111C0001CCC000480 CCRID; 3131C0001000700007 CCRID; 3142C0001000001720 Cell_Model_Passport; SIDM00850 Cosmic-CLP; 906790 DepMap; ACH-000880 IGRhCellID; AGS LINCS_HMS; 50004 LINCS_LDP; LCL-1893 Lonza; 727 TOKU-E; 522 | ||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0001007
CLO; CLO_0001686 EFO; EFO_0002109 MCCL; MCC:0000032 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03471028
BioSample; SAMN03471416 BioSample; SAMN10988305 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308078
ChEMBL-Targets; CHEMBL613860 GDSC; 906790 PharmacoDB; AGS_56_2019 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783 ArrayExpress; E-MTAB-2706 ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 GEO; GSM267417 GEO; GSM267424 GEO; GSM267431 GEO; GSM267438 GEO; GSM552354 GEO; GSM562392 GEO; GSM618009 GEO; GSM618010 GEO; GSM618011 GEO; GSM618012 GEO; GSM827400 GEO; GSM828792 GEO; GSM843440 GEO; GSM886864 GEO; GSM887929 GEO; GSM1237672 GEO; GSM1237697 GEO; GSM1250894 GEO; GSM1250895 GEO; GSM1250896 GEO; GSM1250897 GEO; GSM1374389 GEO; GSM1374390 GEO; GSM1669595 | ||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q54748713 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 685586
Cosmic; 848149 Cosmic; 868235 Cosmic; 873708 Cosmic; 887255 Cosmic; 888819 Cosmic; 906790 Cosmic; 1067211 Cosmic; 1090463 Cosmic; 1187266 Cosmic; 1294957 Cosmic; 1482073 Cosmic; 1518239 Cosmic; 1582429 Cosmic; 1627261 Cosmic; 1995340 Cosmic; 2036659 Cosmic; 2069770 Cosmic; 2484954 Cosmic; 2823227 IARC_TP53; 21171 LiGeA; CCLE_280 Progenetix; CVCL_0139 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD000722 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||||||||||
Version number | 34 |