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Cellosaurus ARO (CVCL_0144)

[Text version]

Cell line name ARO
Synonyms ARO 81-1; ARO81-1; ARO-81; ARO81; UCLA-RO 81; UCLA RO-81-A-1; UCLA RO-81A-1
Accession CVCL_0144
Resource Identification Initiative To cite this cell line use: ARO (RRID:CVCL_0144)
Comments Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=18713817; PubMed=20143388; PubMed=21868764). Originally thought to originate from a thyroid gland anaplastic carcinoma.
From: Juillard G.J.F.; University of California, Los Angeles; Los Angeles; USA.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00177.
Sequence variations Heterozygous for APC p.Glu853Ter (c.2557G>T) and p.Thr1556fs*3 (c.4666_4667insA) (from parent cell line).
Heterozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Heterozygous for PIK3CA p.Pro449Thr (c.1345C>A) (from parent cell line).
Homozygous for SMAD4 p.Gln311Ter (c.931C>T) (from parent cell line).
Homozygous for TP53 p.Arg273His (c.818G>A) (PubMed=8423216; PubMed=14522906).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
STR profile Source(s): PubMed=18713817; PubMed=21868764

Markers:
AmelogeninX
CSF1PO11,12
D3S135815,17
D5S81811,12
D7S82010
D8S117910,16
D13S31711
D16S53911,12
D18S5112,13
D21S1130
FGA20,22
TH016
TPOX8,9
vWA17,19

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=8423216; DOI=10.1172/JCI116168
Fagin J.A., Matsuo K., Karmakar A., Chen D.L., Tang S.H., Koeffler H.P.
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
J. Clin. Invest. 91:179-184(1993)

PubMed=11439348; DOI=10.1038/sj.onc.1204531
Frasca F., Vigneri P., Vella V., Vigneri R., Wang J.Y.J.
Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor.
Oncogene 20:3845-3856(2001)

PubMed=14522906
Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=16924234; DOI=10.1038/sj.onc.1209899
Yu W., Imoto I., Inoue J., Onda M., Emi M., Inazawa J.
A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.
Oncogene 26:1178-1187(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102
Schweppe R.E., Klopper J.P., Korch C., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A., Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cross-references
Cell line databases/resources CGH-DB; 55-1
TOKU-E; 4069
Ontologies BTO; BTO:0002306
MCCL; MCC:0000037
Biological sample resources BioSample; SAMN03151786
BioSample; SAMN03151787
Chemistry resources ChEMBL-Cells; CHEMBL3307996
ChEMBL-Targets; CHEMBL612590
Other Wikidata; Q54750547
Polymorphism and mutation databases Cosmic; 685603
Cosmic; 755291
Cosmic; 849972
Cosmic; 886550
Cosmic; 888094
Cosmic; 888277
Cosmic; 891254
Cosmic; 913250
Cosmic; 918184
Cosmic; 931242
Cosmic; 990532
Cosmic; 1005458
Cosmic; 1094760
Cosmic; 1152116
Cosmic; 1155329
Cosmic; 1162836
Cosmic; 1184761
Cosmic; 1699417
Cosmic; 2050371
IARC_TP53; 2122
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22