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Cellosaurus ARPE-19 (CVCL_0145)

[Text version]

Cell line name ARPE-19
Synonyms ARPE19; Adult Retinal Pigment Epithelial cell line-19; NTC-200; NTC200
Accession CVCL_0145
Resource Identification Initiative To cite this cell line use: ARPE-19 (RRID:CVCL_0145)
Comments Doubling time: 55 hours (from cell counting), 65 hours (from absorbance) (DOI=10.5897/IJBMBR2013.0154).
Omics: Deep proteome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Metabolome analysis.
Omics: Transcriptome analysis.
Misspelling: APRE-19; Occasionally.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IQ60 (ARPE-19/CNTF)CVCL_IQ61 (ARPE-19/EGFP)CVCL_IQ62 (ARPE-19/GDNF)
CVCL_6338 (ARPE-19/HPV-16)CVCL_DF66 (NGC-0295)CVCL_DF67 (NGC-0301)
CVCL_DF68 (NGC-0363)CVCL_DF65 (NGC0211)
Sex of cell Male
Age at sampling 19Y
Category Spontaneously immortalized cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX,Y
CSF1PO11
D5S81813
D7S8209,11
D13S31711,12
D16S5399,11
TH016,9.3
TPOX9,11
vWA16,19

Run an STR similarity search on this cell line
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/a/cell-lines-detail-617.html
Publications

PubMed=8698076; DOI=10.1006/exer.1996.0020
Dunn K.C., Aotaki-Keen A.E., Putkey F.R., Hjelmeland L.M.
ARPE-19, a human retinal pigment epithelial cell line with differentiated properties.
Exp. Eye Res. 62:155-169(1996)

PubMed=11504951; DOI=10.1073/pnas.171266298
Lund R.D., Adamson P., Sauve Y., Keegan D.J., Girman S.V., Wang S., Winton H.L., Kanuga N., Kwan A.S.L., Beauchene L., Zerbib A., Hetherington L., Couraud P.-O., Coffey P., Greenwood J.
Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats.
Proc. Natl. Acad. Sci. U.S.A. 98:9942-9947(2001)

PubMed=16262907; DOI=10.1186/1471-2415-5-25
Sharma R.K., Orr W.E., Schmitt A.D., Johnson D.A.
A functional profile of gene expression in ARPE-19 cells.
BMC Ophthalmol. 5:25-25(2005)

PubMed=21697133; DOI=10.1167/iovs.11-7479
Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011)

DOI=10.5897/IJBMBR2013.0154
Iloki Assanga S.B., Gil-Salido A.A., Lewis Lujan L.M., Rosas-Durazo A., Acosta-Silva A.L., Rivera-Castaneda E.G., Rubio-Pino J.L.
Cell growth curves for different cell lines and their relationship with biological activities.
Int. J. Biotechnol. Mol. Biol. Res. 4:60-70(2013)

PubMed=24251032; DOI=10.1155/2013/216359
Pasovic L., Utheim T.P., Maria R., Lyberg T., Messelt E.B., Aabel P., Chen D.F., Chen X., Eidet J.R.
Optimization of storage temperature for cultured ARPE-19 cells.
J. Ophthalmol. 2013:216359-216359(2013)

PubMed=25177495; DOI=10.1155/2014/801787
Kuznetsova A.V., Kurinov A.M., Aleksandrova M.A.
Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium.
J. Ophthalmol. 2014:801787-801787(2014)

PubMed=28978645; DOI=10.1074/jbc.M117.812677
Chiang C.-K., Tworak A., Kevany B.M., Xu B., Mayne J., Ning Z., Figeys D., Palczewski K.
Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium.
J. Biol. Chem. 292:19826-19839(2017)

PubMed=29476476; DOI=10.1007/978-1-4939-7680-5_17
Fasler-Kan E., Aliu N., Wunderlich K., Ketterer S., Ruggiero S., Berger S., Meyer P.
The retinal pigment epithelial cell line (ARPE-19) displays mosaic structural chromosomal aberrations.
Methods Mol. Biol. 1745:305-314(2018)

Cross-references
Cell line collections ATCC; CRL-2302
BCRC; 60383
BCRJ; 0041
IZSLER; BS CL 193
Cell line databases/resources Lonza; 871
Ontologies BTO; BTO:0002335
CLO; CLO_0001749
EFO; EFO_0006271
MCCL; MCC:0000038
Biological sample resources BioSample; SAMN03471862
Gene expression databases GEO; GSM1227434
Metabolomic databases MetaboLights; MTBLS213
Other Wikidata; Q28812659
Proteomic databases PRIDE; PXD006125
PRIDE; PXD006269
PRIDE; PXD009607