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Cellosaurus ARPE-19 (CVCL_0145)

[Text version]

Cell line name ARPE-19
Synonyms ARPE19; Adult Retinal Pigment Epithelial cell line-19; NTC-200; NTC200
Accession CVCL_0145
Resource Identification Initiative To cite this cell line use: ARPE-19 (RRID:CVCL_0145)
Comments Doubling time: 55 hours (from cell counting), 65 hours (from absorbance) (DOI=10.5897/IJBMBR2013.0154).
Omics: Deep proteome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Metabolome analysis.
Omics: Transcriptome analysis.
Misspelling: APRE-19; Occasionally.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IQ60 (ARPE-19/CNTF)CVCL_IQ61 (ARPE-19/EGFP)CVCL_IQ62 (ARPE-19/GDNF)
CVCL_6338 (ARPE-19/HPV-16)CVCL_DF66 (NGC-0295)CVCL_DF67 (NGC-0301)
CVCL_DF68 (NGC-0363)CVCL_DF65 (NGC0211)
Sex of cell Male
Age at sampling 19Y
Category Spontaneously immortalized cell line
STR profile Source(s): ATCC; PubMed=27499609

Markers:
AmelogeninX,Y
CSF1PO11
D2S133819
D3S135814,15
D5S81813
D6S104317,19
D7S8209,11
D8S117913
D12S39121,22
D13S31711,12
D16S5399,11
D18S5112,16
D19S43312,13
D21S1128,29
FGA23
Penta D11,13
Penta E7,11
TH016,9.3
TPOX9,11
vWA16,19

Run an STR similarity search on this cell line
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/a/cell-lines-detail-617.html
http://www.cellresource.cn/fdetail.aspx?id=2000
Publications

PubMed=8698076; DOI=10.1006/exer.1996.0020
Dunn K.C., Aotaki-Keen A.E., Putkey F.R., Hjelmeland L.M.
ARPE-19, a human retinal pigment epithelial cell line with differentiated properties.
Exp. Eye Res. 62:155-169(1996)

PubMed=11504951; DOI=10.1073/pnas.171266298
Lund R.D., Adamson P., Sauve Y., Keegan D.J., Girman S.V., Wang S., Winton H.L., Kanuga N., Kwan A.S.L., Beauchene L., Zerbib A., Hetherington L., Couraud P.-O., Coffey P., Greenwood J.
Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats.
Proc. Natl. Acad. Sci. U.S.A. 98:9942-9947(2001)

PubMed=14551534
Rogojina A.T., Orr W.E., Song B.K., Geisert E.E. Jr.
Comparing the use of Affymetrix to spotted oligonucleotide microarrays using two retinal pigment epithelium cell lines.
Mol. Vis. 9:482-496(2003)

PubMed=16262907; DOI=10.1186/1471-2415-5-25
Sharma R.K., Orr W.E., Schmitt A.D., Johnson D.A.
A functional profile of gene expression in ARPE-19 cells.
BMC Ophthalmol. 5:25-25(2005)

PubMed=21697133; DOI=10.1167/iovs.11-7479
Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011)

DOI=10.5897/IJBMBR2013.0154
Iloki Assanga S.B., Gil-Salido A.A., Lewis Lujan L.M., Rosas-Durazo A., Acosta-Silva A.L., Rivera-Castaneda E.G., Rubio-Pino J.L.
Cell growth curves for different cell lines and their relationship with biological activities.
Int. J. Biotechnol. Mol. Biol. Res. 4:60-70(2013)

PubMed=24251032; DOI=10.1155/2013/216359
Pasovic L., Utheim T.P., Maria R., Lyberg T., Messelt E.B., Aabel P., Chen D.F., Chen X., Eidet J.R.
Optimization of storage temperature for cultured ARPE-19 cells.
J. Ophthalmol. 2013:216359-216359(2013)

PubMed=25177495; DOI=10.1155/2014/801787
Kuznetsova A.V., Kurinov A.M., Aleksandrova M.A.
Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium.
J. Ophthalmol. 2014:801787-801787(2014)

PubMed=27499609
Wang Y., Sang A.-M., Zhu M.-H., Zhang G.-W., Guan H.-J., Ji M., Chen H.
Tissue factor induces VEGF expression via activation of the Wnt/beta-catenin signaling pathway in ARPE-19 cells.
Mol. Vis. 22:886-897(2016)

PubMed=28978645; DOI=10.1074/jbc.M117.812677
Chiang C.-K., Tworak A., Kevany B.M., Xu B., Mayne J., Ning Z., Figeys D., Palczewski K.
Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium.
J. Biol. Chem. 292:19826-19839(2017)

PubMed=29476476; DOI=10.1007/978-1-4939-7680-5_17
Fasler-Kan E., Aliu N., Wunderlich K., Ketterer S., Ruggiero S., Berger S., Meyer P.
The retinal pigment epithelial cell line (ARPE-19) displays mosaic structural chromosomal aberrations.
Methods Mol. Biol. 1745:305-314(2018)

PubMed=31254428; DOI=10.1111/ceo.13578
Churm R., Dunseath G.J., Prior S.L., Thomas R.L., Banerjee S., Owens D.R.
Development and characterization of an in vitro system of the human retina using cultured cell lines.
Clin. Exp. Ophthalmol. 0:0-0(2019)

Cross-references
Cell line collections ATCC; CRL-2302
BCRC; 60383
BCRJ; 0041
CCTCC; GDC0323
IZSLER; BS CL 193
Cell line databases/resources CCRID; 3142C0001000000349
Lonza; 871
Ontologies BTO; BTO:0002335
CLO; CLO_0001749
EFO; EFO_0006271
MCCL; MCC:0000038
Biological sample resources BioSample; SAMN03471862
Gene expression databases GEO; GSM1227434
Metabolomic databases MetaboLights; MTBLS213
Other Wikidata; Q28812659
Proteomic databases PRIDE; PXD006125
PRIDE; PXD006269
PRIDE; PXD009607
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number20